What is Pms-Bethanechol?
Pms-Bethanechol stimulates your bladder to empty.
Pms-Bethanechol is used to treat urinary retention (difficulty urinating), which may occur after surgery, after delivering a baby, and in other situations.
Pms-Bethanechol may also be used for purposes other than those listed in this medication guide.
Pms-Bethanechol indications
Pms-Bethanechol is indicated for the treatment of acute postoperative and postpartum non obstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention.
How should I use Pms-Bethanechol?
Use Pms-Bethanechol as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Pms-Bethanechol on an empty stomach, either 1 hour before or 2 hours after a meal. If taken soon after eating, nausea and vomiting may occur.
- If you miss a dose of Pms-Bethanechol, take it as soon as possible. If it is more than 2 hours since your dose was to be taken, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Pms-Bethanechol.
Uses of Pms-Bethanechol in details
Pms-Bethanechol is used to treat acute urirary retention after surgrey, childbirth and due to various diseases of the urinary bladder. Pms-Bethanechol may also be used for treating a disease called congenital megacolon (abnormal dilatation of large intestine which is present from birth) and gastro-esophageal reflux and reflux esophagitis (inflammation of the esophagus due to regurgitation).
Pms-Bethanechol description
A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pms-Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, cardiac rate changes, and bronchial spasms.
Pms-Bethanechol dosage
Dosage must be individualized, depending on the type and severity of the condition to be treated.
Preferably give the drug when the stomach is empty. If taken soon after eating, nausea and vomiting may occur.
The usual adult oral dose ranges from 10 to 50 mg three or four times a day. The minimum effective dose is determined by giving 5 to 10 mg initially and repeating the same amount at hourly intervals until satisfactory response occurs, or until a maximum of 50 mg has been given. The effects of the drug sometimes appear within 30 minutes and are usually maximal within 60 to 90 minutes. The drug effects persist for about one hour.
If necessary, the effects of the drug can be abolished promptly by atropine.
How supplied
Pms-Bethanechol Tablets, USP
5 mg - White, 7/16" diameter, round flat faced bevel edge tablets: one side scored and debossed BCL bisect 5, one side debossed 832, in bottles of 100 and 1000, and in unit dose cartons of 100 tablets (10 cards containing 10 tablets each).
10 mg - White, 7/16" diameter, round flat faced bevel edge tablets; one side scored and debossed BCL bisect 10, one side debossed 832, in bottles of 100. 250 and 1000, and in unit dose cartons of 100 tablets (10 cards containing 10 tablets each).
25 mg - Yellow, 7/16" diameter, round flat faced bevel edge tablets; one side scored and debossed BCL bisect 25, one side debossed 832, in bottles of 100, 250, 500 and 1000, and in unit dose cartons of 100 tablets (10 cards containing 10 tablets each).
50 mg - Yellow, 7/16" diameter, round fiat faced bevel edge tablets; one side scored and debossed BCL bisect 50, one side debossed 832, in bottles of 100, 500 and 1000. and in unit dose cartons of 100 tablets (10 cards containing 10 tablets each).
Store at 20-25°C (68-7?°F) and excursions permitted to 15-30"C (59-86°F).
Dispense in a tight container as defined in the USP
Keep out of reach of children.
Rev. 05-05. Manufactured by: UPSHER-SMITH LABORATORIES, INC. Minneapolis, MN 55447. FDA Rev date: 6/1/2005
Pms-Bethanechol interactions
See also:
What other drugs will affect Pms-Bethanechol?
Special care is required if this drug is given to patients receiving ganglion blocking compounds because a critical fall in blood pressure may occur. Usually, severe abdominal symptoms appear before there is such a fall in the blood pressure.
Pms-Bethanechol side effects
See also:
What are the possible side effects of Pms-Bethanechol?
Adverse reactions are rare following oral administration of Pms-Bethanechol, but are more common following subcutaneous injection. Adverse reactions are more likely to occur when dosage is increased.
The following adverse reactions have been observed: Body as a Whole: malaise; Digestive: abdominal cramps or discomfort, colicky pain, nausea and belching, diarrhea, borborygmi, salivation; Renal: urinary urgency; Nervous System: headache; Cardiovascular: a fall in blood pressure with reflex tachycardia, vasomotor response; Skin: flushing producing a feeling of warmth, sensation of heat about the face, sweating; Respiratory: bronchial constriction, asthmatic attacks; Special Senses: lacrimation, miosis,
Causal Relationship Unknown
The following adverse reactions have been reported, and a causal relationship to therapy with Pms-Bethanechol has not been established: Body as a Whole: malaise; Nervous System: seizures.
Pms-Bethanechol contraindications
See also:
What is the most important information I should know about Pms-Bethanechol?
Hypersensitivity to Pms-Bethanechol tablets, hyperthyroidism, peptic ulcer, latent or active bronchial asthma, pronounced bradycardia or hypotension, vasomotor Instability, coronary artery disease, epilepsy and parkinsonism.
Pms-Bethanechol should not be employed when the strength or integrity of the gastrointestinal or bladder wall is in question, or in the presence of mechanical obstruction; when increased muscular activity of the gastrointestinal tract or urinary bladder might prove harmful, as following recent urinary bladder surgery, gastrointestinal resection and anastomosis, or when there Is possible gastrointestinal obstruction; in bladder neck obstruction, spastic gastrointestinal disturbances, acute inflammatory lesions of the gastrointestinal tract, or peritonitis; or in marked vagotonia.
Active ingredient matches for Pms-Bethanechol:
Bethanechol Chloride in Canada.
| Unit description / dosage (Manufacturer) | Price, USD |
| Tablet; Oral; Bethanechol Chloride 10 mg | |
| Tablet; Oral; Bethanechol Chloride 25 mg | |
| Tablet; Oral; Bethanechol Chloride 50 mg | |
List of Pms-Bethanechol substitutes (brand and generic names): | |
| Hinecol (South Korea) | |
| Macpee (India) | |
| Macpee 25mg TAB / 10 (Intas) | $ 1.29 |
| MACPEE 10 MG TABLET 1 strip / 10 tablets each (Intas) | $ 1.63 |
| MACPEE 25 MG TABLET 1 strip / 10 tablets each (Intas) | $ 1.78 |
| MACPEE tab 25 mg x 10's (Intas) | $ 1.29 |
| Macpee 10mg Tablet (Intas) | $ 0.16 |
| Macpee 25mg Tablet (Intas) | $ 0.18 |
| Miotonachol (Argentina) | |
| Myocholine (Austria) | |
| Tablet; Oral; Bethanechol Chloride 10 mg (Glenwood) | |
| Tablet; Oral; Bethanechol Chloride 25 mg (Glenwood) | |
| Myocholine-Glenwood (Austria, Belgium, Germany, Luxembourg, Switzerland) | |
| Myocholine-Glenwood 10mg (Austria, Luxembourg, Switzerland) | |
| Myocholine-Glenwood 25mg (Austria, Switzerland) | |
| Myotonine (United Kingdom) | |
| Tablet; Oral; Bethanechol Chloride 10 mg (Glenwood) | |
| Tablet; Oral; Bethanechol Chloride 25 mg (Glenwood) | |
| Mytonin (South Korea) | |
| PMS-Bethanechol Chloride (Hong Kong) | |
| PMS-Bethanechol Chloride 10 mg x 100's | |
| Ucholine (Thailand) | |
| Ucholine 5 mg x 10 x 10's (M & H Manufacturing) | |
| Ucholine 5 mg x 100's (M & H Manufacturing) | |
| Ucholine 10 mg x 10 x 10's (M & H Manufacturing) | |
| Ucholine 10 mg x 100's (M & H Manufacturing) | |
| Ucholine tab 10 mg 10 x 10's (M & H Manufacturing) | |
| Ucholine tab 10 mg 100's (M & H Manufacturing) | |
| Ucholine tab 5 mg 10 x 10's (M & H Manufacturing) | |
| Ucholine tab 5 mg 100's (M & H Manufacturing) | |
| Uriflow (Philippines) | |
| Uriflow 25 mg x 100's (Ying Yuan Chemical) | $ 100.00 |
| Uriflow tab 25 mg 100's (Ying Yuan Chemical) | |
| Urivoid (India) | |
| Urivoid 25mg TAB / 10 (Cipla Limited) | $ 1.29 |
| Urivoid 25 mg Tablet (Cipla Limited) | $ 0.13 |
| URIVOID 25 MG TABLET 1 strip / 10 tablets each (Cipla Limited) | $ 1.70 |
| URIVOID tab 25 mg x 10's (Cipla Limited) | $ 1.42 |
| Urivoid 25mg Tablet (Cipla Limited) | $ 0.17 |
| Urocarb (Australia) | |
| UROTON (Poland) | |
| UROTON Capsule/ Tablet / 25mg / 5 x 10 units (Biovena) | $ 9.04 |
| Urotonin (India) | |
| Urotonin 25mg TAB / 50 (VHB Life Sciences Limited) | $ 9.04 |
| 25 mg x 50's (VHB Life Sciences Limited) | $ 9.04 |
| Urotonin 25 mg Tablet (VHB Life Sciences Limited) | $ 0.18 |
| UROTONIN tab 25 mg x 10's (VHB Life Sciences Limited) | $ 1.81 |
| Wecoli (Taiwan) | |
| Wecoli 10 mg x 1000's | |
| Wecoli 10 mg x 100 x 10's | |
| Wecoli 25 mg x 1000's | |
See 66 substitutes for Pms-Bethanechol | |
References
- PubChem. "bethanechol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "bethanechol". http://www.drugbank.ca/drugs/DB01019 (accessed September 17, 2018).
- MeSH. "Parasympathomimetics". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
