Prodel Uses

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Prodel indications

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Infectious-inflammatory diseases caused by microorganisms susceptible to Prodel, including respiratory diseases, diseases of abdominal and pelvic organs, bones, joints, skin, septicemia; severe infections of ENT organs. Treatment of postoperative infections. Prevention and treatment of infections in patients with reduced immunity.

For Prodel Citadel Fine Pharmaceuticals local use: acute and subacute conjunctivitis, blepharoconjunctivitis, blepharitis, bacterial corneal ulcers, keratitis, keratoconjunctivitis, chronic dacryocystitis, meybomity. Infectious lesions in the eyes from injury or contact with foreign bodies. Preoperative prophylaxis in ophthalmic surgery.

Prodel description

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem]

Prodel dosage

Individual. For oral administration dose of Prodel Citadel Fine Pharmaceuticals is 250-750 mg 2 times / day. Treatment duration is from 7-10 days to 4 weeks.

For IV administration a single dose is 200-400 mg, the multiplicity of the introduction is 2 times / day, duration of treatment - 1-2 weeks and more if necessary. May be IV injected as jet but more preferably a drip for 30 minutes.

When Prodel Citadel Fine Pharmaceuticals applied topically instilled 1-2 drops into the lower conjunctival sac of the affected eye every 1-4 hours. After improving the intervals between instillation can be increased. The maximum oral daily dose for adults is 1.5 g.

Prodel interactions

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Activity increases when combined with beta-lactam antibiotics, aminoglycosides, vancomycin, clindamycin, metronidazole. Sukralfat, bismuth preparations, antacids containing aluminum ions, magnesium or calcium, cimetidine, ranitidine, vitamin and mineral supplement, iron sulfate, zinc, didanosine (recommended for 2 hours before or 4 hours after these drugs) reduce the suction. Probenecid, azlocillin increase the concentration in the blood. Decreases clearance and increases in plasma caffeine, aminophylline and theophylline (increased likelihood of side effects). Prodel Citadel Fine Pharmaceuticals enhances the effect of warfarin and other oral anticoagulants (prolongs bleeding time). Increases nephrotoxicity of cyclosporine, increase the risk of CNS excitability and convulsive reactions against the background of NSAIDs. Medicines alkalinizing the urine (citrates, sodium bicarbonate, carbonic anhydrase inhibitors) reduce the solubility (increases the probability of crystalluria). Infusion solutions of Prodel ready to use can be combined with infusion solutions: 0.9% sodium chloride solution, Ringer's solution, Ringer lactate, 5 and 10% dextrose, 10% solution of fructose, and a solution containing 5% dextrose with 0,225 or 0.45% sodium chloride. Incompatible with solutions having a pH > 7.

Prodel side effects

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Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Rare

Fever

skin rash or itching

sore throat and fever

unusual tiredness and weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Abdominal or stomach pain or upset

diarrhea

nausea or vomiting

Rare

Dizziness

hair loss

headache

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Prodel contraindications

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Injection: Prodel is contraindicated in comatose states, in patients who have received large amounts of central-nervous-system depressants (alcohol, sedative hypnotics, including barbiturates, general anesthetics, narcotics, narcotic analgesics, tranquilizers, etc.), and in patients who have demonstrated an idiosyncrasy or hypersensitivity to promethazine.

Under no circumstances should promethazine be given by intra-arterial injection due to the likelihood of severe arteriospasm and the possibility of resultant gangrene

Prodel HCl injection should not be given by the subcutaneous route; evidence of chemical irritation has been noted, and necrotic lesions have resulted on rare occasions following subcutaneous injection. The preferred parenteral route of administration is by deep intramuscular injection.

Syrup, Tablets and Suppositories: Phenergan Tablets and Suppositories are contraindicated for use in pediatric patients less than two years of age.

Phenergan Tablets and Suppositories are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines.

Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma.



Active ingredient matches for Prodel:

Chlorphenamine in Chile, India.

Chlorphenamine maleate in Chile.

Chlorpheniramine Maleate

Ciprofloxacin in India.

Dydrogesterone


Unit description / dosage (Manufacturer)Price, USD
Syrup; Oral; Chlorpheniramine Maleate 2 mg / 5 ml
Tablet; Oral; Chlorpheniramine Maleate 4 mg
Prodel 250mg TAB / 10$ 0.37
Prodel 500mg TAB / 10$ 0.69
250 mg x 10's$ 0.37
500 mg x 10's$ 0.69
PRODEL tab 250 mg x 10's (Citadel)$ 0.37
PRODEL tab 500 mg x 10's (Citadel)$ 0.69

List of Prodel substitutes (brand and generic names):

Tablets, Film-Coated; Oral; Ciprofloxacin Hydrochloride 500 mg
Profilox 500 mg x 100's (Filadams)$ 60.00
Profilox tab 500 mg 100's (Filadams)
Tablet, Film-Coated; Oral; Ciprofloxacin Hydrochloride 250 mg (Clonmel)
Tablet, Film-Coated; Oral; Ciprofloxacin Hydrochloride 500 mg (Clonmel)
Tablet, Film-Coated; Oral; Ciprofloxacin Hydrochloride 750 mg (Clonmel)
Tablets, Film-Coated; Oral; Ciprofloxacin Hydrochloride 250 mg (Clonmel)
Tablets, Film-Coated; Oral; Ciprofloxacin Hydrochloride 500 mg (Clonmel)
Tablets, Film-Coated; Oral; Ciprofloxacin Hydrochloride 750 mg (Clonmel)
PROKEM 250MG TABLET 1 strip / 10 tablets each (Monokem Labs)$ 0.32
PROKEM 500MG TABLET 1 strip / 10 tablets each (Monokem Labs)$ 0.65
Prokem 500mg Tablet (Monokem Labs)$ 0.07
Tablet, Film-Coated; Oral; Ciprofloxacin Hydrochloride 500 mg (Douglas)
Tablet, Film-Coated; Oral; Ciprofloxacin Hydrochloride 750 mg (Douglas)
Tablets, Film-Coated; Oral; Ciprofloxacin Hydrochloride 500 mg (Douglas)
Tablets, Film-Coated; Oral; Ciprofloxacin Hydrochloride 750 mg (Douglas)
Tablet, Extended Release; Oral; Ciprofloxacin Hydrochloride 500 mg
Tablets, Extended Release; Oral; Ciprofloxacin Hydrochloride 500 mg
Proquin XR tablet, film coated, extended release 500 mg/1 (Depomed, Inc. (US))
Tablet; Oral; Ciprofloxacin Hydrochloride Monohydrate 500 mg (Hormona)
Tablets; Oral; Ciprofloxacin Hydrochloride Monohydrate 500 mg (Hormona)
Proviflox 500 mg x 20's (SMHP)
Proviflox film-coated tab 500 mg 20's (SMHP)
PROX Capsule/ Tablet / 500mg / 10 units (Pharmed)$ 0.80
PROX Capsule/ Tablet / 250mg / 10 units (Pharmed)$ 0.41
Prox 250mg TAB / 10 (Pharmed)$ 0.41
Prox 500mg TAB / 10 (Pharmed)$ 0.80
250 mg x 10's (Pharmed)$ 0.41
500 mg x 10's (Pharmed)$ 0.80
PROX tab 250 mg x 10's (Pharmed)$ 0.41
PROX tab 500 mg x 10's (Pharmed)$ 0.80
Prox 250mg TAB / 10 (Pharmed)$ 0.41
Prox 500mg TAB / 10 (Pharmed)$ 0.80
Proxacin 400 mg x 100's (Medreich)
Proxacin 2 mg/1 mL x 1 mL (Medreich)
Proxacin 2 mg/1 mL x 50 mL (Medreich)
Proxacin 2 mg/1 mL x 100 mL (Medreich)

References

  1. DailyMed. "CHLORPHENIRAMINE POLISTIREX; HYDROCODONE POLISTIREX: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "CIPROFLOXACIN; DEXAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubChem. "dydrogesterone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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