Prodoxican Uses

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Prodoxican indications

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Oral

Acute musculoskeletal disorders; Osteoarthritis; Rheumatoid arthritis

Adult: 20 mg as a single dose, taken at the same time each day. Treatment duration: Up to 7 days for acute musculoskeletal disorders and up to 14 days for severe cases.

Elderly: Use the lowest effective dose for the shortest possible duration.

Parenteral

Acute musculoskeletal disorders; Osteoarthritis; Rheumatoid arthritis

Adult: Initially, 20 mg IM/IV as a single dose given for 1-2 days, to be continued w/ the oral form, administered at the same time each day. Treatment duration: Up to 7 days for acute musculoskeletal disorders and up to 14 days for severe cases.

Elderly: Use the lowest effective dose for the shortest duration.

Reconstitution: Dissolve lyophilisate in 2 mL of sterile water for inj.

Uses of Prodoxican in details

Prodoxican is used to reduce pain and inflammation (swelling) of the muscles, tendons, and joints in diseases like arthritis or in short-term injuries, strains, or sprains.

Prodoxican description

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Novo-Prodoxican, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.

Prodoxican dosage

Oral

Acute musculoskeletal disorders; Osteoarthritis; Rheumatoid arthritis

Adult: 20 mg as a single dose, taken at the same time each day. Treatment duration: Up to 7 days for acute musculoskeletal disorders and up to 14 days for severe cases.

Elderly: Use the lowest effective dose for the shortest possible duration.

Parenteral

Acute musculoskeletal disorders; Osteoarthritis; Rheumatoid arthritis

Adult: Initially, 20 mg IM/IV as a single dose given for 1-2 days, to be continued w/ the oral form, administered at the same time each day. Treatment duration: Up to 7 days for acute musculoskeletal disorders and up to 14 days for severe cases.

Elderly: Use the lowest effective dose for the shortest duration.

Reconstitution: Dissolve lyophilisate in 2 mL of sterile water for inj.

Prodoxican interactions

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FELDENE is highly protein bound, and therefore, might be expected to displace other protein-bound drugs. Although this has not occurred in in vitro studies with coumarin-type anticoagulants, interactions with coumarin-type anticoagulants have been reported with FELDENE since marketing, therefore, physicians should closely monitor patients for a change in dosage requirements when administering FELDENE to patients on coumarin-type anticoagulants and other highly protein-bound drugs.

Plasma levels of piroxicam are depressed to approximately 80% of their normal values when FELDENE is administered in conjunction with aspirin (3900 mg/day), but concomitant administration of antacids has no effect on piroxicam plasma levels.

Nonsteroidal anti-inflammatory agents, including FELDENE, have been reported to increase steady state plasma lithium levels. It is recommended that plasma lithium levels be monitored when initiating, adjusting and discontinuing FELDENE.

Prodoxican side effects

Cardiovascular

Edema; weight gain; CHF; alterations in BP; vasodilation; palpitations; tachycardia.

CNS

Headache; malaise; dizziness; somnolence; vertigo; depression; insomnia; nervousness.

Dermatologic

Pruritus; rash; sweating; erythema; bruising; desquamation; erythema multiforme; toxic epidermal necrolysis.

EENT

Tinnitus; swollen eyes; blurred vision; eye irritation; rhinitis; pharyngitis.

GI

Epigastric distress; nausea; vomiting; anorexia; constipation; stomatitis; abdominal discomfort; diarrhea; flatulence; abdominal pain; indigestion; toxicity (bleeding, ulceration, perforation); heartburn; dyspepsia; anorexia.

Genitourinary

Hematuria; proteinuria; increased BUN and serum creatinine; acute renal insufficiency and failure; papillary necrosis; interstitial nephritis; nephrotic syndrome; hyperkalemia; hyponatremia.

Hematologic

Increased bleeding time; decreased Hgb and Hct; anemia; leukopenia; eosinophilia, thrombocytopenia.

Hepatic

Increased LFTs; elevated liver enzymes.

Respiratory

Bronchospasm; laryngeal edema; dyspnea; hemoptysis; shortness of breath.

Prodoxican contraindications

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Hypersensitivity to Prodoxican, aspirin or other NSAIDs. History of or active peptic ulceration, GI bleeding (melaena, haematemesis) or severe gastritis; severe heart failure. Last trimester of pregnancy.

Active ingredient matches for Prodoxican:

Tenoxicam in Brazil.


List of Prodoxican substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Pycitil 20 mg x 1 Bottle in 1 tube dung mobi
Pycityl 20 mg x 1 Bottle boät
Pycityl 20 mg x 1 Box 1 Bottle
Redac 25mg Combi-Pack / 1 (Ritz Pharma)$ 0.71
Redac 50mg Combi-Pack / 1 (Ritz Pharma)$ 1.14
25 mg x 1's (Ritz Pharma)$ 0.71
50 mg x 1's (Ritz Pharma)$ 1.14
REDAC inj 25 mg x 1ml (Ritz Pharma)$ 0.71
REDAC inj 50 mg x 1ml (Ritz Pharma)$ 1.14
Rheuflex 20 mg x 100's (Goldcrest)
Seftil 20 mg x 25 x 10's (Unison)
Seftil 20 mg x 10 x 10's (Unison)
Seftil FC tab 20 mg 25 x 10's (Unison)
Sinoral 20 mg x 25 x 10's (Biolab)
Sutondin 10 mg
Sutondin 20 mg x 1000's
Teconam 20 mg x 500's (Asian pharm)
Tenax 20 mg x 100's (Siam Bheasach)
Tenax 20 mg x 500's (Siam Bheasach)
Tenax FC tab 20 mg 10 x 10's (Siam Bheasach)
Tencam 20 mg x 100's
Tencam 20 mg x 10's
Tenocam 20 mg x 250's (Eurofarma)
Tenogesic 20 mg x 10 x 10's

References

  1. PubChem. "tenoxicam". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "tenoxicam". http://www.drugbank.ca/drugs/DB00469 (accessed September 17, 2018).
  3. DTP/NCI. "tenoxicam: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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