What is Semilinc?
Semilinc is an antibiotic that fights bacteria.
Semilinc is used to treat severe bacterial infections in people who cannot use penicillin antibiotics.
Semilinc is used only for a severe infection. This medicine will not treat a viral infection such as the common cold or flu.
Semilinc may also be used for purposes not listed in this medication guide.
Semilinc indications
Semilinc Sterile Solution is indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci. Its use should be reserved for penicillin-allergic patients or other patients for whom, in the judgment of the physician, a penicillin is inappropriate. Because of the risk of antibiotic-associated pseudomembranous colitis, as described in Warnings, before selecting Semilinc the physician should consider the nature of the infection and the suitability of less toxic alternatives (e.g., erythromycin).
Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to Semilinc.
Indicated surgical procedures should be performed in conjunction with antibiotic therapy.
Semilinc has been demonstrated to be effective in the treatment of staphylococcal infections resistant to other antibiotics and susceptible to Semilinc. Staphylococcal strains resistant to Semilinc have been recovered; culture and susceptibility studies should be done in conjunction with therapy with Semilinc. In the case of macrolides, partial but not complete cross-resistance may occur. The drug may be administered concomitantly with other antimicrobial agents when indicated.
Semilinc is not indicated in the treatment of minor bacterial infections or viral infections.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Semilinc and other antibacterial drugs, Semilinc should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
How should I use Semilinc?
Use Semilinc as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Semilinc is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
- If you miss a dose of Semilinc, call your doctor to find out what to do.
Ask your health care provider any questions you may have about how to use Semilinc.
Uses of Semilinc in details
Semilinc is used in treatment of bacterial infections.
Semilinc description
Each mL of Semilinc Sterile Solution contains Lincomycin hydrochloride equivalent to Semilinc 300 mg.
Semilinc sterile solution contains Lincomycin hydrochloride which is the monohydrated salt of Semilinc, a substance produced by the growth of a member of the lincolnensis group of Streptomyces lincolnensis (Fam. Streptomycetaceae).
The chemical name for Semilinc hydrochloride is Methyl 6, 8-dideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrolidinecarboxamido)-1-thio-D-erythro-α-D-galacto-octopyranoside monohydrochloride monohydrate. Its molecular formula is C18H34N2O6S.HCl. H2O and the molecular weight is 461.01.
Semilinc hydrochloride is a white or practically white, crystalline powder and is odorless or has a faint odor. Its solutions are acid and are dextrorotatory. Semilinc hydrochloride is freely soluble in water; soluble in dimethylformamide and very slightly soluble in acetone.
Excipients/Inactive Ingredients: Benzyl alcohol 9.45 mg added as preservative.
Semilinc dosage
Semilinc Dosage
Generic name: Semilinc HYDROCHLORIDE 300mg in 1mL
Dosage form: injection, solution
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
If significant diarrhea occurs during therapy, this antibacterial should be discontinued.
INTRAMUSCULAR
Adults
Serious infections—600 mg (2 mL) intramuscularly every 24 hours. More severe infections—600 mg (2 mL) intramuscularly every 12 hours or more often.
Pediatric patients over 1 month of age
Serious infections—one intramuscular injection of 10 mg/kg (5 mg/lb) every 24 hours. More severe infections—one intramuscular injection of 10 mg/kg (5 mg/lb) every 12 hours or more often.
INTRAVENOUS
Adults
The intravenous dose will be determined by the severity of the infection. For serious infections doses of 600 mg of Semilinc (2 mL of Semilinc) to 1 gram are given every 8 to 12 hours. For more severe infections these doses may have to be increased. In life-threatening situations daily intravenous doses of as much as 8 grams have been given.
Intravenous doses are given on the basis of 1 gram of Semilinc diluted in not less than 100 mL of appropriate solution and infused over a period of not less than one hour.
| Dose | Vol. Diluent | Time |
|---|---|---|
| 600 mg | 100 mL | 1 hr |
| 1 gram | 100 mL | 1 hr |
| 2 grams | 200 mL | 2 hr |
| 3 grams | 300 mL | 3 hr |
| 4 grams | 400 mL | 4 hr |
These doses may be repeated as often as required to the limit of the maximum recommended daily dose of 8 grams of Semilinc.
Pediatric patients over 1 month of age
10 to 20 mg/kg/day (5 to 10 mg/lb/day) depending on the severity of the infection may be infused in divided doses as described above for adults.
NOTE: Severe cardiopulmonary reactions have occurred when this drug has been given at greater than the recommended concentration and rate.
SUBCONJUNCTIVAL INJECTION
0.25 mL (75 mg) injected subconjunctivally will result in ocular fluid levels of antibacterial (lasting for at least 5 hours) with MICs sufficient for most susceptible pathogens.
Patients with diminished renal function
When therapy with Semilinc is required in individuals with severe impairment of renal function, an appropriate dose is 25 to 30% of that recommended for patients with normally functioning kidneys.
More about Semilinc (Semilinc)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Espanol
- 1 Review - Add your own review/rating
- Generic Availability
Consumer resources
- Semilinc
- Semilinc (Advanced Reading)
Professional resources
- Semilinc (AHFS Monograph)
- Semilinc (FDA)
Related treatment guides
- Bacterial Infection
- Conjunctivitis, Bacterial
Semilinc interactions
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What other drugs will affect Semilinc?
BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Monitor therapy
Cholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Avoid combination
Doxofylline: Semilinc may increase the serum concentration of Doxofylline. Monitor therapy
Erythromycin (Systemic): May diminish the therapeutic effect of Semilinc. Avoid combination
Kaolin: May decrease the absorption of Lincosamide Antibiotics. Monitor therapy
Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Monitor therapy
Mecamylamine: Lincosamide Antibiotics may enhance the neuromuscular-blocking effect of Mecamylamine. Avoid combination
Neuromuscular-Blocking Agents: Lincosamide Antibiotics may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Monitor therapy
Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Consider therapy modification
Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected. Management: Vaccination with live attenuated typhoid vaccine (Ty21a) should be avoided in patients being treated with systemic antibacterial agents. Use of this vaccine should be postponed until at least 3 days after cessation of antibacterial agents. Consider therapy modification
Semilinc side effects
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What are the possible side effects of Semilinc?
Applies to Semilinc: capsule, solution
In addition to its needed effects, some unwanted effects may be caused by Semilinc (the active ingredient contained in Semilinc). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Semilinc:
More common:
- Abdominal or stomach cramps and pain (severe)
- abdominal tenderness
- diarrhea (watery and severe), which may also be bloody
- fever
- Skin rash, redness, and itching
- sore throat and fever
- unusual bleeding and bruising
Note: Some of the above side effects may also occur up to several weeks after you Stop taking Semilinc.
Minor Side Effects
Some of the side effects that can occur with Semilinc may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
- Diarrhea (mild)
- nausea and vomiting
- stomach pain
- Itching of rectal or genital (sex organ) areas
Semilinc contraindications
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What is the most important information I should know about Semilinc?
Before receiving Semilinc, tell your doctor if you have asthma or allergies, a stomach or intestinal disorder such as colitis, liver or kidney disease, or epilepsy or other seizure disorder.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
Serious side effects of Semilinc include fever, chills, body aches, flu symptoms, white patches or sores inside your mouth or on your lips, severe blistering or peeling skin rash, feeling like you might pass out, easy bruising or bleeding, unusual weakness, or urinating less than usual or not at all.
Active ingredient matches for Semilinc:
| Unit description / dosage (Manufacturer) | Price, USD |
| Semilinc 500 mg Capsule | $ 0.12 |
| Semilinc 30 ml Syrup | $ 0.10 |
List of Semilinc substitutes (brand and generic names): | |
| Nolipo 500 (Indonesia) | |
| Nolipo 500 500 mg x 10 x 10's (Sanbe) | $ 45.76 |
| Ocnil (United Kingdom) | |
| Ocnil 25 mg Tablet (Raikar Pharmaceuticals Pvt. Ltd.) | $ 0.04 |
| Olin Hcl | |
| Olin Hcl 600 mg Injection (Paksons Pharmaceuticals (P) Ltd.) | $ 0.12 |
| Omicin (Myanmar) | |
| OMICIN 20 MG CAPSULE 1 strip / 10 capsules each (Calibar) | $ 0.37 |
| OMICIN cap 20 mg x 10's (Calibar) | $ 0.39 |
| Omicin 20mg Capsule (Calibar) | $ 0.04 |
| Pecasolin (Greece) | |
| Pelancocin (Japan) | |
| Percocyn (Indonesia) | |
| Percocyn 500 mg x 10 x 10's (Landson) | $ 17.05 |
| Premelange 40 / 2 Porcs Lincomix | |
| Drug Premix; Oral; Lincomycin 5.5 g / kg | |
| Princol (Mexico) | |
| Pritalinc (Indonesia) | |
| Pritalinc 500 mg x 6 x 10's (Molex ayus) | $ 16.74 |
| PROLINC (India) | |
| 300 mg x 2 mL x 2ml (Prohealth) | $ 0.20 |
| Prolinc 300mg x 2mL INJ / 2ml (Prohealth) | $ 0.20 |
| PROLINC inj 300 mg x 2 mL x 2ml (Prohealth) | $ 0.20 |
| Prolinc 300mg x 2mL INJ / 2ml (Prohealth) | $ 0.20 |
| Pura Ject 100 | |
| Rimsalin (Mexico) | |
| SHELINC | |
| SHELINC 300MG INJECTION 1 vial / 1 ML injection each (Windlas Biotech Ltd) | $ 0.12 |
| SHELINC 600MG INJECTION 1 vial / 2 ML injection each (Windlas Biotech Ltd) | $ 0.21 |
| Shelinc 600mg Injection (Windlas Biotech Ltd) | $ 0.11 |
| Sintolin (Italy) | |
| Splinc | |
| Splinc 500 mg Capsule (Spire Pharma) | $ 0.11 |
| Splinc 250 mg Capsule (Spire Pharma) | $ 0.07 |
| Tamcocin (Indonesia) | |
| Tamcocin 500 mg x 100's (Pyridam) | $ 45.88 |
| Teclind (Brazil) | |
| Tismamisin (Indonesia) | |
| Tismamisin 250 mg x 10 x 10's (Metiska) | $ 23.56 |
| Tismamisin 500 mg x 10 x 10's (Metiska) | $ 35.96 |
| Ultralinc (Bahrain, Iraq, Jordan, Kuwait, Lebanon, Libya, Nigeria, Qatar, Saudi Arabia, Sudan, Syria, Tunisia, United Arab Emirates, Yemen) | |
| Unolin (Thailand) | |
| Unolin 200 mg/1 mL x 1 mL | |
| Unolin 300 mg/1 mL x 1 mL | |
| Uto Lincomycin (Thailand) | |
| Uto Lincomycin 300 mg/1 mL x 2 mL x 1's | |
| Uto Lincomycin 300 mg/1 mL x 10 mL x 1's | |
| Utolincomycin (Thailand) | |
| Vedelinko (Estonia) | |
| Vualin (Netherlands) | |
| Yectolin (Mexico) | |
| Injectable; Injection; Lincomycin Hydrochloride 300 mg / ml (Grossman) | |
| Zencocin (Indonesia) | |
| Zencocin 500 (Indonesia) | |
| Zencocin 500 500 mg x 10 x 10's (Zenith Pharmaceuticals) | |
| Zencosin (Indonesia) | |
| Zumalin (Indonesia) | |
| Zumalin 500 mg x 10 x 5's (Sandoz) | $ 18.60 |
See 519 substitutes for Semilinc | |
References
- PubChem. "lincomycin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "lincomycin". http://www.drugbank.ca/drugs/DB01627 (accessed September 17, 2018).
- MeSH. "Protein Synthesis Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Semilinc are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Semilinc. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
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Information checked by Dr. Sachin Kumar, MD Pharmacology
