What is Starzine?
Starzine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Starzine is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose.
Starzine is also used to treat itching and swelling caused by chronic urticaria (hives).
Starzine may also be used for purposes not listed in this medication guide.
Starzine indications
Perennial Allergic Rhinitis : Starzine
Oral Solution, USP is indicated for the relief of symptoms associated with perennial allergic rhinitis due to allergens such as dust mites, animal dander and molds in children 6 to 23 months of age. Symptoms treated effectively include sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, and tearing.
Chronic Urticaria: Starzine
Oral Solution, USP is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in children 6 months to 5 years of age. It significantly reduces the occurrence, severity, and duration of hives and significantly reduces pruritus.
How should I use Starzine?
Use Starzine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Do not remove the blister unit from the carton until you are ready to take Starzine. Make sure that your hands are dry when you open the blister unit. Do not push the tablet through the foil. Peel back the foil on the blister unit and place the tablet on your tongue. The tablet dissolves quickly and can be swallowed with saliva. Starzine may be taken with or without water. Take the tablet immediately after opening the blister unit. Do not store the removed tablet for future use.
- If you miss a dose of Starzine and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Starzine.
Uses of Starzine in details
Use: Labeled Indications
Oral:
Allergic rhinitis: Relief of symptoms associated with allergic rhinitis.
Urticaria, chronic spontaneous: Treatment of uncomplicated skin manifestations of chronic spontaneous urticaria.
Injection:
Urticaria, acute: Treatment of acute urticaria.
Off Label Uses
Anaphylaxis (adjunct to epinephrine for relief of cutaneous symptoms)
Based on joint guidelines from the American Academy of Allergy, Asthma & Immunology, American College of Allergy, Asthma & Immunology, and Joint Council of Allergy, Asthma and Immunology on the diagnosis and management of anaphylaxis and guidelines from the World Allergy Organization on anaphylaxis, Starzine may be used as adjunctive treatment, although should not be used as monotherapy or as first-line therapy of anaphylaxis.
Angioedema, acute allergic or recurrent idiopathic
Clinical experience suggests the utility of second-generation H receptor antagonists (eg, Starzine) for the treatment of acute allergic or recurrent idiopathic angioedema.
Starzine description
Starzine HCl is a piperazine derivative and a metabolite of hydroxyzine. It competes reversibly with histamine to block the histamine (H1) receptor sites. Starzine HCl is considered a long-acting nonsedating antihistamine and has some mast-cell stabilizing activity.
Starzine dosage
Starzine
Oral Solution, USP can be taken without regard to food consumption.
Children 2 to 5 Years for Chronic Urticaria: The recommended initial dose of Starzine
Oral Solution, USP in children aged 2 to 5 years is 2.5 mg (½ teaspoonful) syrup once daily. The dosage in this age group can be increased to a maximum dose of 5 mg per day given as 1 teaspoonful syrup once a day, or one ½ teaspoonful syrup given every 12 hours.
Children 6 months to < 2 years for Perennial Allergic Rhinitis and Chronic Urticaria: The recommended dose of Starzine
Oral Solution, USP in children 6 months to 23 months of age is 2.5 mg (½ teaspoonful) once daily. The dose in children 12 to 23 months of age can be increased to a maximum dose of 5 mg per day, given as ½ teaspoonful (2.5 mg) every 12 hours.
Starzine interactions
See also:
What other drugs will affect Starzine?
Theophylline decreases the clearance of Starzine although the disposition of theophylline is not affected.
In common with other antihistamines it is recommended that excessive alcohol consumption be avoided. Concurrent use of Starzine with other CNS depressants should also be avoided as reduction in alertness and impairment of performance may occur.
No evidence of interactions with antipyrine, azithromycin, cimetidine, diazepam, erythromycin, ketoconazole and pseudoephedrine has been reported.
Starzine side effects
See also:
What are the possible side effects of Starzine?
The following clinically significant adverse reaction is described elsewhere in the labeling:
- Somnolence/Sedation
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Oral Starzine
The following adverse reactions associated with the use of oral Starzine were identified in clinical trials.
In clinical trials in patients 12 years and older the most common adverse reactions to oral Starzine occurring with a 2% or greater incidence and greater than placebo were somnolence (14%), fatigue (6%), dry mouth (5%), pharyngitis (2%), and dizziness (2%). In clinical trials in children 6 to 11 years of age with oral Starzine the most common adverse reactions occurring with a 2% or greater incidence and greater than placebo were headache, pharyngitis, abdominal pain, coughing, somnolence, diarrhea, epistaxis, bronchospasm, nausea, and vomiting. Somnolence appeared to be dose related. Adverse reactions reported in placebo-controlled trials with oral Starzine in pediatric patients 2 to 5 years were qualitatively similar in nature and generally similar in frequency to those reported in trials with children 6 to 11 years of age. In placebo-controlled trials of pediatric patients 6 to 24 months of age, the incidences of adverse experiences were similar in the oral Starzine and placebo treatment groups in each trial. In a trial of 1 week duration in children 6 to 11 months of age patients who received oral Starzine exhibited greater irritability/fussiness than patients on placebo. In a trial of 18 months duration in patients 12 months and older, insomnia occurred more frequently in patients who received oral Starzine compared to patients who received placebo.
Starzine
The safety data of Starzine was evaluated in a randomized, double-blind, single-dose, non-inferiority study comparing Starzine to intravenous diphenhydramine in 262 adults with acute urticaria.
The adverse reactions with Starzine occurred at an incidence of less than 1% and include: dyspepsia, feeling hot, dysgeusia, headache, paresthesia, presyncope, and hyperhidrosis.
An additional randomized, double-blind, single dose study was conducted in 33 adults which showed similar safety results.
Sedation
Subject-rated sedation scores were assessed at baseline, 1 hr, and/or 2 hrs, and/or "Readiness for Discharge”. Sedation was rated on a 0 to 3 scale (0 = none, to 3 = severe) with lower sedation scores indicating less sedation. Subjects in the Starzine treatment group reported less sedation at all time points compared to subjects treated with diphenhydramine.
Starzine contraindications
See also:
What is the most important information I should know about Starzine?
The use of Starzine is contraindicated in patients with a known hypersensitivity to Starzine or any of its ingredients, levocetirizine, or hydroxyzine.
Active ingredient matches for Starzine:
Cetirizine Hydrochloride in India.
Cetirizine dihydrochloride in India.
| Unit description / dosage (Manufacturer) | Price, USD |
| Starzine 10mg TAB / 100 | $ 3.01 |
| 10 mg x 100's | $ 3.01 |
| Starzine 10 mg Tablet | $ 0.03 |
| STARZINE tab 10 mg x 10's (Captab) | $ 0.30 |
List of Starzine substitutes (brand and generic names): | |
| Speedcet | |
| Speedcet 10mg TAB / 10 | |
| Stcold (India) | |
| Stcold Cetirizine 5 mg, Pseudoephedrine 30 mg, Paracetamol 500 mg. TAB / 10 (Plus India) | $ 0.36 |
| 10's (Plus India) | $ 0.36 |
| STCOLD tab 10's (Plus India) | $ 0.36 |
| Sytra (India) | |
| Sytra 10mg FC-TAB / 100 (Synokem Pharmaceuticals Ltd) | $ 2.52 |
| 10 mg x 100's (Synokem Pharmaceuticals Ltd) | $ 2.52 |
| Sytra 10 mg Tablet (Synokem Pharmaceuticals Ltd) | $ 0.03 |
| SYTRA 10MG TABLET 1 strip / 10 tablets each (Synokem Pharmaceuticals Ltd) | $ 0.21 |
| SYTRA film-coated tab 10 mg x 10's (Synokem Pharmaceuticals Ltd) | $ 0.25 |
| Sytra 10mg Tablet (Synokem Pharmaceuticals Ltd) | $ 0.02 |
| Tab Arid (India) | |
| Tab Arid Cetirizine hydrochloride 10mg, Pseudoephedrine 60 mg, Ambroxol hydrochloride 30 mg. TAB / 100 (Siesta Pharmaceuticals) | $ 3.01 |
| 100's (Siesta Pharmaceuticals) | $ 3.01 |
| Tab Arid 60+30+10 Tablet (Siesta Pharmaceuticals) | $ 0.03 |
| TAB ARID tab 10's (Siesta Pharmaceuticals) | $ 0.30 |
| Taurcet-A (India) | |
| Taurcet-A Ambroxol hydrochloride 60 mg, Cetirizine hydrochloride 10mg. TAB / 10 (Taurus Labs) | $ 0.24 |
| 10's (Taurus Labs) | $ 0.24 |
| TAURCET-A tab 10's (Taurus Labs) | $ 0.24 |
| Trilert (India) | |
| Trilert 10mg TAB / 10 (Trigenesis Lifesciences Pvt. Ltd.) | $ 0.28 |
| 10 mg x 10's (Trigenesis Lifesciences Pvt. Ltd.) | $ 0.28 |
| Trilert 10 mg Tablet (Trigenesis Lifesciences Pvt. Ltd.) | $ 0.03 |
| TRILERT tab 10 mg x 10's (Trigenesis Lifesciences Pvt. Ltd.) | $ 0.28 |
| Trizin-10 | |
| Trizin-10 10mg TAB / 10x5x10 | $ 14.46 |
| Troz-10 | |
| Troz-10 10mg TAB / 10 | |
| Trozan-OD (India) | |
| Trozan-OD Cetirizine dihydrochloride 5mg, Diethylcarbamazine 120 mg SYR / 60ml (Stedman) | $ 0.43 |
| Trozan-OD Cetirizine dihydrochloride 10mg, Diethylcarbamazine 300 mg. FC-TAB / 150 (Stedman) | $ 6.51 |
| Trozan-OD Cetirizine dihydrochloride 5mg, diethylcarbamazine citrate120 mg/5 mL. SYR / 60ml (Stedman) | $ 0.43 |
| Trozan-OD Cetirizine dihydrochloride 10mg, diethylcarbamazine citrate300 mg. FC-TAB / 10x15 (Stedman) | $ 6.51 |
| TROZAN-OD syr 60ml (Stedman) | $ 0.43 |
| TROZAN-OD film-coated tab 10's (Stedman) | $ 0.43 |
| Trucet | |
| Trucet 10mg TAB / 10 (Trugen Pharmaceuticals Pvt. Ltd) | $ 0.18 |
| Trucet 10 mg Tablet (Trugen Pharmaceuticals Pvt. Ltd) | $ 0.02 |
| Turbozine (India) | |
| Turbozine Cetirizine, Paracetamol, Phenylephrine. TAB (Sterling Lab (Medi-Genix)) | |
| TURBOZINE tab 10's (Sterling Lab (Medi-Genix)) | |
| Tzine (India) | |
| Tzine 10mg TAB / 250 (Health Care) | $ 7.83 |
| 10 mg x 250's (Health Care) | $ 7.83 |
| TZINE tab 10 mg x 10's (Health Care) | $ 0.31 |
| Viscodyne-D (India) | |
| Viscodyne-D Dextromethorphan hydrochloride10 mg, Cetirizine 5 mg, Ammonium chloride 100 mg, Zinc15 mcg/10 mL. LIQD / 100ml (Wockhardt (Merind)) | $ 0.37 |
| 100ml (Wockhardt (Merind)) | $ 0.37 |
| Viscodyne-D Dextromethorphan hydrochloride10 mg, cetirizine 5 mg, ammonium chloride 100 mg, zinc15 mg/10 mL. LIQD / 100ml (Wockhardt (Merind)) | $ 0.37 |
| VISCODYNE-D 0.8 MG/10 MG SYRUP 1 bottle / 100 ML syrup each (Wockhardt (Merind)) | $ 0.90 |
| VISCODYNE-D syr 100ml (Wockhardt (Merind)) | $ 0.60 |
| Xero-Sed (India) | |
| Xero-Sed 10mg TAB / 10 (Max) | $ 0.13 |
See 668 substitutes for Starzine | |
References
- DailyMed. "CETIRIZINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "cetirizine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "cetirizine". http://www.drugbank.ca/drugs/DB00341 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Starzine are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Starzine. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
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Information checked by Dr. Sachin Kumar, MD Pharmacology
