Suramine indications
Infectious-inflammatory diseases caused by microorganisms susceptible to ciprofloxacin, including respiratory diseases, diseases of abdominal and pelvic organs, bones, joints, skin, septicemia; severe infections of ENT organs. Treatment of postoperative infections. Prevention and treatment of infections in patients with reduced immunity.
For Suramine Citadel Fine Pharmaceuticals local use: acute and subacute conjunctivitis, blepharoconjunctivitis, blepharitis, bacterial corneal ulcers, keratitis, keratoconjunctivitis, chronic dacryocystitis, meybomity. Infectious lesions in the eyes from injury or contact with foreign bodies. Preoperative prophylaxis in ophthalmic surgery.
Suramine description
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem]
Suramine dosage
Individual. For oral administration dose of Suramine Citadel Fine Pharmaceuticals is 250-750 mg 2 times / day. Treatment duration is from 7-10 days to 4 weeks.
For IV administration a single dose is 200-400 mg, the multiplicity of the introduction is 2 times / day, duration of treatment - 1-2 weeks and more if necessary. May be IV injected as jet but more preferably a drip for 30 minutes.
When Suramine Citadel Fine Pharmaceuticals applied topically instilled 1-2 drops into the lower conjunctival sac of the affected eye every 1-4 hours. After improving the intervals between instillation can be increased. The maximum oral daily dose for adults is 1.5 g.
Suramine interactions
Activity increases when combined with beta-lactam antibiotics, aminoglycosides, vancomycin, clindamycin, metronidazole. Sukralfat, bismuth preparations, antacids containing aluminum ions, magnesium or calcium, cimetidine, ranitidine, vitamin and mineral supplement, iron sulfate, zinc, didanosine (recommended for 2 hours before or 4 hours after these drugs) reduce the suction. Probenecid, azlocillin increase the concentration in the blood. Decreases clearance and increases in plasma caffeine, aminophylline and theophylline (increased likelihood of side effects). Suramine Citadel Fine Pharmaceuticals enhances the effect of warfarin and other oral anticoagulants (prolongs bleeding time). Increases nephrotoxicity of cyclosporine, increase the risk of CNS excitability and convulsive reactions against the background of NSAIDs. Medicines alkalinizing the urine (citrates, sodium bicarbonate, carbonic anhydrase inhibitors) reduce the solubility (increases the probability of crystalluria). Infusion solutions of ciprofloxacin ready to use can be combined with infusion solutions: 0.9% sodium chloride solution, Ringer's solution, Ringer lactate, 5 and 10% dextrose, 10% solution of fructose, and a solution containing 5% dextrose with 0,225 or 0.45% sodium chloride. Incompatible with solutions having a pH > 7.
Suramine side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Rare
Fever
skin rash or itching
sore throat and fever
unusual tiredness and weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Abdominal or stomach pain or upset
diarrhea
nausea or vomiting
Rare
Dizziness
hair loss
headache
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Suramine contraindications
Injection: Suramine is contraindicated in comatose states, in patients who have received large amounts of central-nervous-system depressants (alcohol, sedative hypnotics, including barbiturates, general anesthetics, narcotics, narcotic analgesics, tranquilizers, etc.), and in patients who have demonstrated an idiosyncrasy or hypersensitivity to promethazine.
Under no circumstances should promethazine be given by intra-arterial injection due to the likelihood of severe arteriospasm and the possibility of resultant gangrene
Suramine HCl injection should not be given by the subcutaneous route; evidence of chemical irritation has been noted, and necrotic lesions have resulted on rare occasions following subcutaneous injection. The preferred parenteral route of administration is by deep intramuscular injection.
Syrup, Tablets and Suppositories: Phenergan Tablets and Suppositories are contraindicated for use in pediatric patients less than two years of age.
Phenergan Tablets and Suppositories are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines.
Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma.
Active ingredient matches for Suramine:
Chlorphenamine in Thailand.
Chlorpheniramine maleate in Thailand.
| Unit description / dosage (Manufacturer) | Price, USD |
| Suramine 4 mg x 1, 000's | |
| Suramine 2 mg/5 mL x 60 mL | |
List of Suramine substitutes (brand and generic names): | |
| Sunso (Taiwan) | |
| Sunso 60 mL | |
| Suzivan Oval | |
| Suzivan Oval 4 mg Tablet (Suzikem Drugs Pvt. Ltd.) | $ 0.02 |
| Swiminic (India) | |
| Swiminic Phenylephrine HCI 12.5mg, Chlorepheniramine Maleate 1mg, Paracetamol 125mg DPS / 15ml (Ind-Swift Limited) | $ 0.39 |
| 15ml (Ind-Swift Limited) | $ 0.39 |
| Swiminic 15 ml Drop (Ind-Swift Limited) | $ 0.03 |
| Swiminic Phenylephrine hydrochloride12.5 mg, Chlorpheniraminemaleate 1 mg, Paracetamol 125mg. DPS / 15ml (Ind-Swift Limited) | $ 0.39 |
| SWIMINIC oral drops 15ml (Ind-Swift Limited) | $ 0.39 |
| Synacold | |
| Synacold 500+30+4 Tablet (Kim Laboratories Pvt Ltd.) | $ 0.01 |
| SYNACOLD DROPS 1 packet / 15 ML drop each (Kim Laboratories Pvt Ltd.) | $ 0.37 |
| SYNACOLD SYRUP 1 bottle / 50 ML syrup each (Kim Laboratories Pvt Ltd.) | $ 0.42 |
| SYNACOLD TABLET 1 strip / 10 tablets each (Kim Laboratories Pvt Ltd.) | $ 0.30 |
| Synacold Drop (Kim Laboratories Pvt Ltd.) | $ 0.37 |
| Synacold Syrup (Kim Laboratories Pvt Ltd.) | $ 0.42 |
| Synarin Tablet | |
| Synarin Tablet (Embiotic Laboratories (P) Ltd.) | $ 0.03 |
| T- Minic Plus SYP | |
| T- Minic Plus SYP Chlorepheniramine Maleate 1mg, Phenylephrine HCI 2.5mg, Paracetamol 500mg SYR / 60ml | $ 0.39 |
| T-Minic DPS (India) | |
| T-Minic DPS Chlorepheniramine maleate 2mg, Phenylephrine HCI 5mg/5mL DPS / 15ml (Novartis (OTC)) | $ 0.42 |
| 15ml (Novartis (OTC)) | $ 0.42 |
| T-Minic Dps Chlorphenamine maleate 2 mg, Phenylephrine hydrochloride 5mg/5 mL. DPS / 15ml (Novartis (OTC)) | $ 0.42 |
| T-MINIC DPS oral drops 15ml (Novartis (OTC)) | $ 0.64 |
| T-Minic Dps Chlorphenamine maleate 2 mg, Phenylephrine hydrochloride 5mg/5 mL. DPS / 15ml (Novartis (OTC)) | $ 0.42 |
| T-Minic SYP (India) | |
| T-Minic SYP Chlorepheniramine maleate 2mg, Phenylephrine HCI 5mg/5mL SYR / 60ml (Novartis (OTC)) | $ 0.37 |
| 60ml (Novartis (OTC)) | $ 0.45 |
| T-Minic Syp Chlorphenamine maleate 2 mg, Phenylephrine hydrochloride 5mg/5 mL. SYR / 60ml (Novartis (OTC)) | $ 0.45 |
| T-MINIC SYP syr 60ml (Novartis (OTC)) | $ 0.69 |
| T-Minic Syp Chlorphenamine maleate 2 mg, Phenylephrine hydrochloride 5mg/5 mL. SYR / 60ml (Novartis (OTC)) | $ 0.45 |
| Tags D | |
| Tags D 100 ml Syrup (Arlak Biotech Pvt Ltd) | $ 0.03 |
| Tbrox CD | |
| Tbrox CD 50 ml Syrup (Technica Labs & Pharma Pvt Ltd) | $ 0.03 |
| Tbrox CD 100 ml Syrup (Technica Labs & Pharma Pvt Ltd) | $ 0.03 |
| TCR D | |
| TCR D 100 ml Syrup (Oneiro Pharmaceuticals Pvt.Ltd) | $ 0.02 |
| Td Alermine | |
| Teldrin (United States) | |
| Capsule, Extended Release; Oral; Chlorpheniramine Maleate 8 mg (Smithkline beecham consumer) | |
| Capsule, Extended Release; Oral; Chlorpheniramine Maleate 12 mg (Smithkline beecham consumer) | |
| Terlex D | |
| Terlex D 100 ml Syrup (Oasis Laboratories Pvt.Ltd) | $ 0.02 |
| Terlex D 60 ml Syrup (Oasis Laboratories Pvt.Ltd) | $ 0.03 |
| Terlin DM | |
| Terlin DM 100 ml Syrup (Hinglaj Laboratories of India) | $ 0.00 |
| Terlin DX | |
| Terlin DX 100 ml Syrup (Hinglaj Laboratories of India) | $ 0.00 |
| Ticos (Taiwan) | |
| Ticos | |
| Tonpicon (Taiwan) | |
| Tonpicon 1000's | |
| Tossex DMR | |
| Tossex DMR 100 ml Syrup (Abbott Healthcare Pvt Ltd (AHPL)) | $ 0.03 |
| TOSSEX DMR 4 MG/10 MG SYRUP 1 bottle / 100 ML syrup each (Abbott Healthcare Pvt Ltd (AHPL)) | $ 0.87 |
| Tossex Dmr Syrup (Abbott Healthcare Pvt Ltd (AHPL)) | $ 0.87 |
| Trigenic (India) | |
| Trigenic 60 ml Syrup (Trigenesis Lifesciences Pvt. Ltd.) | $ 0.03 |
See 1240 substitutes for Suramine | |
References
- DailyMed. "CHLORPHENIRAMINE POLISTIREX; HYDROCODONE POLISTIREX: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "chlorpheniramine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "chlorpheniramine". http://www.drugbank.ca/drugs/DB01114 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Suramine are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Suramine. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yet4 consumers reported age
| Users | % | ||
|---|---|---|---|
| 1-5 | 2 | 50.0% | |
| 6-15 | 1 | 25.0% | |
| > 60 | 1 | 25.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
