What is Tossex-S?
Chlorpheniramine (Tossex-S) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Codeine (Tossex-S) is a narcotic cough suppressant. It affects the signals in the brain that trigger cough reflex.
Chlorpheniramine (Tossex-S) and Codeine (Tossex-S) is a combination medicine used to treat runny nose, sneezing, itching, watery eyes, and cough caused by allergies, the common cold, or the flu.
Chlorpheniramine (Tossex-S) and Codeine (Tossex-S) will not treat a cough that is caused by smoking, asthma, or emphysema.
Chlorpheniramine (Tossex-S) and Codeine (Tossex-S) may also be used for purposes not listed in this medication guide.
Tossex-S indications
Tossex-S is indicated for the temporary relief of cough, as may occur with the common cold or inhaled irritants, and for the temporary relief of runny nose, sneezing, itching of the nose or throat, and itchy watery eyes due to hay fever, other upper respiratory allergies, or allergic rhinitis.
How should I use Tossex-S?
Use Tossex-S suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Tossex-S suspension by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Shake well before each use.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Drinking extra fluids while you are taking Tossex-S suspension is recommended. Check with your doctor for instructions.
- If you miss a dose of Tossex-S suspension and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Tossex-S suspension.
Uses of Tossex-S in details
This combination product is used to treat symptoms caused by the common cold, flu, allergies, hay fever, or other breathing illnesses (e.g., sinusitis, bronchitis). This product contains a narcotic cough suppressant (antitussive) that affects a certain part of the brain, reducing the urge to cough. Antihistamines relieve watery eyes, itchy eyes/nose/throat, runny nose, and sneezing.
Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, this product is not recommended to treat cold symptoms in children younger than 6 years. Some products (including some long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.
These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Giving more than the recommended dose or using this medication along with other cough-and-cold products has resulted in serious (even fatal) side effects, including slowed/stopped breathing. Talk to the doctor or pharmacist before giving other cough-and-cold medication that might contain the same or similar ingredients. Ask about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray). Do not use this product to make a child sleepy.
How to use Tossex-S
Read the Patient Information Leaflet if available from your pharmacist before you start taking this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food with a full glass of water (8 ounces or 240 milliliters) or as directed by your doctor. This medication may be taken with food or milk if stomach upset occurs. Do not take the sustained-release products more often than every 12 hours.
If you are using the liquid form, use a medication measuring device or spoon to carefully measure the prescribed dose. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well before each dose.
If you are using the extended-release capsules, swallow them whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
If you are using a sustained-release liquid that contains hydrocodone polistirex, do not mix the liquid with other liquids or medications. Doing so can destroy the long action of the drug and may increase side effects.
This medication may cause withdrawal reactions, especially if it has been used regularly for a long time (more than a few weeks) or in high doses. In such cases, withdrawal symptoms (such as anxiety, restlessness, sweating, shaking chills, nausea, vomiting, and diarrhea) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.
Though it is very unlikely to occur, this medication can also result in abnormal drug-seeking behavior (addiction/habit forming). Do not increase your dose, take it more frequently, or use it for a longer time than prescribed. Properly stop the medication when so directed. This will lessen the chances of becoming addicted.
When used for an extended time, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well.
Inform your doctor if your condition persists for more than 1 week, if it worsens, or if it occurs with fever, rash, or persistent headache. These may be symptoms of a serious medical problem and should be checked by a doctor.
Tossex-S dosage
Tossex-S Dosage
Generic name: Codeine (Tossex-S) PHOSPHATE 10mg in 5mL, Chlorpheniramine (Tossex-S) MALEATE 2mg in 5mL
Dosage form: oral liquid
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Adults and children 12 years of age and over: 1 to 2 teaspoonfuls (5-10 mL) every 4 to 6 hours. Not to exceed 8 teaspoonfuls in a 24 hour period. Children 6 to under 12 years of age: 1/2 to 1 teaspoonful (2.5 - 5 mL) every 4 to 6hours. Not to exceed 4 teaspoonfuls in a 24 hour period.
*In mild cases or in particularly sensitive patients, less frequent or reduced doses may be appropriate and adequate.
More about Tossex-S (Chlorpheniramine (Tossex-S) / Codeine (Tossex-S))
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Espanol
- 0 Reviews - Add your own review/rating
Consumer resources
- Tossex-S
- Other brands: Tuzistra XR, Tossex-S, Tossex-S, Zodryl AC, More (4) »
Professional resources
- Tossex-S (FDA)
Related treatment guides
- Allergic Rhinitis
- Cold Symptoms
- Cough
- Cough and Nasal Congestion
Tossex-S interactions
See also:
What other drugs will affect Tossex-S?
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include: anticholinergic drugs (e.g., benztropine, belladonna alkaloids), antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray), cimetidine, MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine), narcotic antagonists (e.g., naltrexone, naloxone), scopolamine, tricyclic antidepressants (e.g., amitriptyline, desipramine).
Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., Codeine (Tossex-S)), psychiatric medicines (e.g., chlorpromazine, risperidone, trazodone). Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products.
This medication may interfere with certain laboratory tests (including amylase/lipase levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.
Tossex-S side effects
See also:
What are the possible side effects of Tossex-S?
Adverse reactions listed below have been reported in the literature for Codeine (Tossex-S) and Chlorpheniramine (Tossex-S) and may be expected to occur with Tossex-S. Also included are events which occurred during clinical pharmacokinetic studies (in a total of 147 healthy adult volunteers with either single or multiple dose exposure) with Tossex-S and judged by the investigator to be related to study treatment. There are insufficient data to support a statement regarding distribution of adverse events by gender, race and age.
Body as a Whole
Asthenia, feeling of relaxation, redness or flushing of the face, unusual tiredness or weakness.
Allergic
Allergic laryngospasm, atelectasis, bronchospastic allergic reaction, hives, itching, swelling of face.
Cardiovascular
Fast, slow, or pounding heartbeat, hypertension, hypotension, orthostatic hypotension, palpitation, shock-like state, syncope.
Dermatologic System
Dermatitis, excessive perspiration, urticaria, erythema, pruritus, rash.
Endocrine
Changes in glucose utilization, decreased lactation, early menses, glycosuria, gynecomastia, hypoglycemia, increased appetite, increased libido, pheochromocytoma stimulation.
Gastrointestinal
Abdominal distension, abdominal pain, acute pancreatitis, constipation, diarrhea, dry mouth, dyspepsia, epigastric distress, loss of appetite, nausea, vomiting; also observed with opioids: decreased gastric motility with increased likelihood of esophageal reflux.
Genitourinary
Dysuria, irritative bladder symptoms, urinary frequency, urinary hesitancy, urinary retention, ureteral spasm.
Nervous System
Blurred, double, or other visual disturbances; confusion; dizziness; depression; drowsiness and sedation; headache; euphoria; facial dyskinesia; false sense of well-being; feeling faint, lightheadedness, general feeling of discomfort or illness; may cause excitability, especially in children; nervousness, agitation and restlessness; minimal sedation; somnolence; also observed with antihistamine agents: insomnia, dyskinesia, irritability, tremor.
Respiratory System
Dryness of pharynx and respiratory passages, laryngismus, nasal stuffiness, wheezing or troubled breathing, respiratory depression.
Special Senses
Ears: labyrinthitis, tinnitus, vertigo; eyes: blurred vision, diplopia, hypermetropia, lacrimation increased, mydriasis, photophobia.
Other
Drug fever.
Tossex-S contraindications
See also:
What is the most important information I should know about Tossex-S?
Patients with hypersensitivity or idiosyncrasy to any of its ingredients. Do not use in newborn infants, premature infants, in nursing mothers, in patients with severe hypertension, severe coronary artery disease, ischemic heart disease, or in those receiving monoamine oxidase (MAO) inhibitors. Tossex-S Liquid should not be used during pregnancy or in nursing mothers.
Antihistamines are contraindicated in patients with narrow-angle glaucoma, urinary retention, peptic ulcer, and during an asthma attack. Antihistamines should not be used to treat lower respiratory tract conditions including asthma.
Active ingredient matches for Tossex-S:
Chlorpheniramine Maleate/Codeine Phosphate
List of Tossex-S substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| REXTAS | |
| REXTAS syr 50ml (Intas) | $ 0.47 |
| Rextas 4 mg/10 mg Syrup (Intas) | $ 0.95 |
| RONRYL-CD (India) | |
| RONRYL-CD syr 100ml (Am. Biocare) | $ 0.94 |
| SILENSER (India) | |
| SILENSER 4MG/10MG SYRUP 1 bottle / 50 ML syrup each (Parenteral Drugs) | $ 0.40 |
| SILENSER 4MG/10MG SYRUP 1 bottle / 100 ML syrup each (Parenteral Drugs) | $ 0.87 |
| SILENSER syr 100ml (Parenteral Drugs) | $ 0.84 |
| SINACT-CS (India) | |
| SINACT-CS syr 100ml (Pharmatech HC) | $ 0.84 |
| SINACT-CS syr 60ml (Pharmatech HC) | $ 0.51 |
| SMODI (India) | |
| SMODI syr 100ml (Pax Healthcare) | $ 1.02 |
| SOTHREX C | |
| SOTHREX C SYRUP 1 bottle / 100 ML syrup each (Psychotropics India Ltd) | $ 0.38 |
| Supkof | |
| Supkof 100 ml Syrup (Obsurge Biotech Limited) | $ 0.04 |
| SUPKOF 4MG/10MG SYRUP 1 bottle / 100 ML syrup each (Obsurge Biotech Limited) | $ 0.78 |
| Supkof 4 mg/10 mg Syrup (Obsurge Biotech Limited) | $ 0.60 |
| Supkof T Syrup (Obsurge Biotech Limited) | $ 1.19 |
| THIOKOF CD | |
| THIOKOF CD 4MG/10MG SYRUP 1 bottle / 100 ML syrup each (Synthiko Formulations & Pharma Pvt Ltd) | $ 0.78 |
| Thiokof CD 4 mg/10 mg Syrup (Synthiko Formulations & Pharma Pvt Ltd) | $ 0.78 |
| TL-Hist CM | |
| TL-HIST CM Liquid | |
| TREATCOF (India) | |
| TREATCOF syr 100ml (Treatwell) | $ 0.75 |
| TRUSTYL CD | |
| TRUSTYL CD 4MG/10MG SYRUP 1 bottle / 100 ML syrup each (Abbott India Ltd) | $ 0.89 |
| Tuxarin ER | |
| WOTLIN (India) | |
| WOTLIN syr 100ml (Acinom Healthcare) | $ 1.02 |
| XENOCOF D | |
| XENOCOF D 4MG/10MG SYRUP 1 bottle / 100 ML syrup each (Orchid Chemicals & Pharmaceuticals Ltd) | $ 0.72 |
| Xenocof D 4 mg/10 mg Syrup (Orchid Chemicals & Pharmaceuticals Ltd) | $ 0.72 |
| XEPIN COUGH | |
| XEPIN COUGH 4MG/10MG SYRUP 1 bottle / 100 ML syrup each (Sysmed Laboratories Pvt Ltd) | $ 0.74 |
| Xepin Cough 4 mg/10 mg Syrup (Sysmed Laboratories Pvt Ltd) | $ 0.74 |
| XPECT C | |
| XPECT C 4 MG/10 MG SYRUP 1 bottle / 100 ML syrup each (Alkem Laboratories Ltd) | $ 0.93 |
| XPECT-C (India) | |
| XPECT-C syr 100ml (Alkem (Ulticare)) | $ 0.85 |
| Z-Tuss AC | |
| Z-Tuss AC Liquid | |
| ZENODYL (India) | |
| ZENODYL syr 100ml (Zenon) | |
| Zodryl AC | |
| Zodryl AC 25 | |
| Zodryl AC 30 | |
| Zodryl AC 35 | |
| Zodryl AC 40 | |
| Zodryl AC 50 | |
| Zodryl AC 60 | |
| Zodryl AC 80 | |
| Zodryl AC Adult | |
| Zodryl AC Suspension | |
See 209 substitutes for Tossex-S | |
References
- DailyMed. "CHLORPHENIRAMINE POLISTIREX; HYDROCODONE POLISTIREX: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "CODEINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "codeine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Tossex-S are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Tossex-S. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported useful
Was the Tossex-S drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
| Users | % | ||
|---|---|---|---|
| Useful | 1 | 100.0% | |
Consumer reported price estimates
No survey data has been collected yet1 consumer reported time for results
To what extent do I have to use Tossex-S before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Tossex-S. To get the time effectiveness of using Tossex-S drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 1 day | 1 | 100.0% | |
1 consumer reported age
| Users | % | ||
|---|---|---|---|
| 30-45 | 1 | 100.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
