Tussantiol Uses

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Tussantiol indications

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Tussantiol is a mucolytic agent for the adjunctive therapy of respiratory tract disorders characterised by excessive, viscous mucus, including chronic obstructive airways disease.

Uses of Tussantiol in details

Tussantiol is used along with other medications as adjunctive therapy to treat conditions of the respiratory tract which causes difficulty in breathing, including chronic obstructive airways disease.

Tussantiol description

Tussantiol is a mucolytic that reduces the viscosity of sputum and so can be used to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis by allowing the sufferer to bring up sputum more easily. Tussantiol should not be used with antitussives (cough suppressants) or medicines that dry up bronchial secretions. Tussantiol is produced by alkylation of cysteine with chloroacetic acid.

Tussantiol dosage

Capsule: Adult and Children ≥12 years: 1 capsule. Forte Suspension: Adult and Children ≥12 years: 5 mL (1 tsp). 100 mg/5 mL Pediatric Suspension: Children 8-12 years: 15 mL (3 tsp), 4-7 years: 10 mL (2 tsp), 2-3 years: 5 mL (1 tsp). 200 mg/5 mL Pediatric Suspension: Children 8-12 years: 7.5 mL, 4-7 years: 5 mL, 2-3 years: 2.5 mL. Infant

Oral Drops:

Infants 1-2 years: 1.5 mL. All doses to be taken orally every 8 hrs.

Tussantiol interactions

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mixing Tussantiol with pholcodine linctus causes precipitation of Tussantiol from solution but no information is given on whether this incompatibility is with the pholcodine or some component of the formulation used.

Tussantiol side effects

Capsules, Syrup and Paediatric Syrup:

Immune System Disorders

There have been reports of anaphylactic reactions and fixed drug eruption.

Skin and subcutaneous tissue disorders

There have been reports of skin rashes and allergic skin eruptions.

Capsules and Syrup:

Gastrointestinal disorders

There have been rare reports of gastrointestinal bleeding occurring during treatment with Tussantiol.

Tussantiol contraindications

Adult Syrup: Gastroduodenal ulceration.

Children Syrup: Known hypersensitivity to any of the components of Tussantiol Children Syrup, in particular to parabens. Children <2 years due to risk of worsening airway congestion.

Active ingredient matches for Tussantiol:

Carbocisteine in Switzerland.

Carbocysteine


Unit description / dosage (Manufacturer)Price, USD
Syrup; Oral; Carbocisteine 250 mg / 5 ml

List of Tussantiol substitutes (brand and generic names):

Tanlin 375 mg
Tecyteine 375 mg x 1000's
Throatsil-CBS 375 mg x 50 x 10's (Millimed)
Throatsil-CBS 100 mg/5 mL x 60 mL (Millimed)
Throatsil-CBS 250 mg/5 mL x 60 mL (Millimed)
Throatsil-CBS syr 100 mg/5 mL 60 mL x 1's (Millimed)
Throatsil-CBS syr 250 mg/5 mL 60 mL x 1's (Millimed)
Throatsil-CBS tab 375 mg 50 x 10's (Millimed)
Solution; Oral; Carbocisteine 7.5%
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Capsule; Oral; Carbocisteine (Meda)
Trimulex 500 mg x 100's (Medi-Rx)$ 23.12
Trimulex 250 mg/5 mL x 60 mL (Medi-Rx)$ 3.02
Trimulex 50 mg/1 mL x 15 mL (Medi-Rx)$ 2.37
Trimulex cap 500 mg 100's (Medi-Rx)$ 23.12
Trimulex oral drops 50 mg/mL 15 mL x 1's (Medi-Rx)$ 2.37
Trimulex oral susp 250 mg/5 mL 60 mL x 1's (Medi-Rx)$ 3.02
Syrup; Oral; Carbocisteine 2% (Zydus)
Syrup; Oral; Carbocisteine 5% (Zydus)
Syrup; Oral; Carbocisteine 5%
Solution; Oral; Carbocisteine 5%
Syrup; Oral; Carbocisteine 2%
Solution; Oral; Carbocisteine 5%
Viscodec 500 mg x 100's$ 12.44
Westcarbox 500 mg x 100's (Lloyd)$ 12.71
Westcarbox 100 mg/5 mL x 60 mL (Lloyd)$ 1.07
Westcarbox 50 mg/1 mL x 15 mL (Lloyd)$ 1.00
Zoradine / raspberry flavour 100 mg/5 mL x 90 mL
Zylotin 500 mg x 100's (Virgo)$ 22.79
Zylotin 250 mg/5 mL x 60 mL (Virgo)$ 2.12
Zymelytic / Sour-grape flavor 250 mg/5 mL x 60 mL (Blooming fields)$ 1.67

References

  1. PubChem. "carbocysteine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "carbocysteine". http://www.drugbank.ca/drugs/DB04339 (accessed September 17, 2018).
  3. MeSH. "Expectorants". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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