Actions of Tussantiol in details
Tussantiol, a derivative of acetylcysteine, is a mucoregulating agent. Its major action is thought to be on the metabolism of mucus-producing cells. The mucus produced under the influence of Tussantiol has an increased content of the less viscous sialomucin and a reduced content of the highly viscous fucomucin. Sialomucins influence the rheological properties of mucus and may also, through the inhibition of kinins, reduce or prevent bronchial inflammation and bronchospasm.
Tussantiol is rapidly and well-absorbed after oral administration. Following oral administration of 1.5 g Tussantiol, peak serum concentration of 13-16 mg/L was reached in 1-2 hrs. Plasma t½ was 1.5-2 hrs. Tussantiol penetrates well into lung tissues and respiratory mucus suggesting local action. Tussantiol undergoes acetylation, decarboxylation and sulfoxidation. Majority of Tussantiol is excreted unchanged in the urine.
Tussantiol administration
Should be taken with food.
Tussantiol pharmacology
Tussantiol enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies.
References
- EPA DSStox. "S-(Carboxymethyl)-L-cysteine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
