What is Uphamol 650?
Uphamol 650 injection is used together with other medicines (eg, narcotic pain relievers) to relieve moderate to severe pain.
Uphamol 650 is used to relieve mild to moderate pain and reduce fever in patients. It does not become habit-forming when taken for a long time. Uphamol 650 may cause unwanted effects when taken in large doses, including liver damage.
Uphamol 650 is available only with your doctor's prescription.
Uphamol 650 indications
Uphamol 650 Injection is indicated for
- the management of mild to moderate pain in adult and pediatric patients 2 years and older
- the management of moderate to severe pain with adjunctive opioid analgesics in adult and pediatric patients 2 years and older
- the reduction of fever in adult and pediatric patients.
How should I use Uphamol 650?
Use Uphamol 650 injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Uphamol 650 injection is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Uphamol 650 injection at home, a health care provider will teach you how to use it. Be sure you understand how to use Uphamol 650 injection. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not mix other medicines (especially chlorpromazine or diazepam) in the same container or IV line as Uphamol 650 injection. Contact your health care provider if you have any questions about how to give Uphamol 650 injection with other medicines.
- Do not use Uphamol 650 injection if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Use Uphamol 650 injection within 6 hours after opening.
- If you miss a dose of Uphamol 650 injection and you are using it regularly, use it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Uphamol 650 injection.
Uses of Uphamol 650 in details
This drug is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever.
How to use Uphamol 650 Jr
Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.
There are many brands and forms of Uphamol 650 available. Read the dosing instructions carefully for each product because the amount of Uphamol 650 may be different between products. Do not take more Uphamol 650 than recommended.
If you are giving Uphamol 650 to a child, be sure you use a product that is meant for children. Use your child's weight to find the right dose on the product package. If you don't know your child's weight, you can use their age.
For suspensions, shake the medication well before each dose. Some liquids do not need to be shaken before use. Follow all directions on the product package. Measure the liquid medication with the provided dose-measuring spoon/dropper/syringe to make sure you have the correct dose. Do not use a household spoon.
For rapidly-dissolving tablets, chew or allow to dissolve on the tongue, then swallow with or without water. For chewable tablets, chew thoroughly before swallowing.
Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
For effervescent tablets, dissolve the dose in the recommended amount of water, then drink.
Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well.
Do not take this medication for fever for more than 3 days unless directed by your doctor. For adults, do not take this product for pain for more than 10 days (5 days in children) unless directed by your doctor. If the child has a sore throat (especially with high fever, headache, or nausea/vomiting), consult the doctor promptly.
Tell your doctor if your condition persists or worsens or if you develop new symptoms. If you think you may have a serious medical problem, get medical help right away.
Uphamol 650 description
Uphamol 650 (with the Optizorb formulation) also contains the following excipients: Pregelatinized maize starch, calcium carbonate, alginic acid, crospovidone, povidone, magnesium stearate, colloidal anhydrous silica, parahydroxybenzoates (sodium methyl, ethyl and propyl), OPADRY YS-1-7003 white, carnauba wax, purified water.
It contains no sugar, lactose or gluten.
Uphamol 650 dosage
General Dosing Information
Uphamol 650 Injection may be given as a single or repeated dose for the treatment of acute pain or fever. No dose adjustment is required when converting between oral Uphamol 650 and Uphamol 650 Injection dosing in adults and adolescents who weigh 50 kg and above. Calculated maximum daily dose of Uphamol 650 is based on all routes of administration (i.e., intravenous, oral, and rectal) and all products containing Uphamol 650. Exceeding the maximum mg/kg daily dose of Uphamol 650 as described in Tables 1 to 3 may result in hepatic injury, including the risk of liver failure and death. To avoid the risk of overdose, ensure that the total amount of Uphamol 650 from all routes and from all sources does not exceed the maximum recommended dose.
Recommended
Dosage: Adults and Adolescents
Adults and adolescents weighing 50 kg and over: the recommended dosage of Uphamol 650 Injection is 1,000 mg every 6 hours or 650 mg every 4 hours, with a maximum single dose of Uphamol 650 Injection of 1,000 mg, a minimum dosing interval of 4 hours, and a maximum daily dose of Uphamol 650 of 4,000 mg per day (includes all routes of administration and all Uphamol 650-containing products including combination products).
Adults and adolescents weighing under 50 kg: the recommended dosage of Uphamol 650 Injection is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Uphamol 650 Injection of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of Uphamol 650 of 75 mg/kg per day (includes all routes of administration and all Uphamol 650-containing products including combination products).
| Age group | Dose given every 4 hours | Dose given every 6 hours | Maximum single dose | Maximum total daily dose of Uphamol 650 (by all routes) |
|---|---|---|---|---|
| Adults and adolescents (13 years and older) weighing ≥ 50 kg | 650 mg | 1,000 mg | 1,000 mg | 4,000 mg in 24 hours |
| Adults and adolescents (13 years and older) weighing < 50 kg | 12.5 mg/kg | 15 mg/kg | 15 mg/kg (up to 750 mg) | 75 mg/kg in 24 hours (up to 3,750 mg) |
Recommended
Dosage: Children
Children 2 to 12 years of age: the recommended dosage of Uphamol 650 Injection is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Uphamol 650 Injection of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of Uphamol 650 of 75 mg/kg per day.
| Age group | Dose given every 4 hours | Dose given every 6 hours | Maximum single dose | Maximum total daily dose of Uphamol 650 (by all routes) |
| Children 2 to 12 years of age | 12.5 mg/kg | 15 mg/kg | 15 mg/kg (up to 750 mg) | 75 mg/kg in 24 hours (up to 3,750 mg) |
Recommended Dosage for Treatment of Fever in Neonates and Infants
Neonates, including premature neonates born at ≥ 32 weeks gestational age, up to 28 days chronological age: the recommended dosage of Uphamol 650 is 12.5 mg/kg every 6 hours, to a maximum daily dose of Uphamol 650 of 50 mg/kg per day, with a minimum dosing interval of 6 hours.
Infants 29 days to 2 years of age: the recommended dosage of Uphamol 650 is 15 mg/kg every 6 hours, to a maximum daily dose of Uphamol 650 of 60 mg/kg per day, with a minimum dosing interval of 6 hours.
| Age group | Dose given every 6 hours | Maximum total daily dose of Uphamol 650 (by all routes) |
| Neonates (birth to 28 days) | 12.5 mg/kg | 50 mg/kg |
| Infants (29 days to 2 years) | 15 mg/kg | 60 mg/kg |
Instructions for
Intravenous Administration
For adult and adolescent patients weighing ≥ 50 kg requiring 1,000 mg doses of Uphamol 650 Injection, administer the dose by inserting a vented intravenous set through the septum of the 100 mL vial. Uphamol 650 Injection may be administered without further dilution. Examine the container contents before dose preparation or administering. DO NOT USE if particulate matter or discoloration is observed. Administer the contents of the vial intravenously over 15 minutes. Use aseptic technique when preparing Uphamol 650 Injection for intravenous infusion. Do not add other medications to the Uphamol 650 Injection vial or infusion device.
For doses less than 1,000 mg, the appropriate dose must be withdrawn from the container and placed into a separate container prior to administration. Using aseptic technique, withdraw the appropriate dose (650 mg or weight-based) from an intact sealed Uphamol 650 Injection container and place the measured dose in a separate empty, sterile container (e.g., glass bottle, plastic intravenous container, or syringe) for intravenous infusion to avoid the inadvertent delivery and administration of the total volume of the commercially available container. The entire 100 mL container of Uphamol 650 Injection is not intended for use in patients weighing less than 50 kg. Uphamol 650 Injection is supplied in a single-dose container and the unused portion must be discarded.
Place small volume pediatric doses up to 60 mL in volume in a syringe and administer over 15 minutes using a syringe pump.
Monitor the end of the infusion in order to prevent the possibility of an air embolism, especially in cases where the Uphamol 650 Injection infusion is the primary infusion.
Once the container seal has been penetrated, or the contents transferred to another container, administer the dose of Uphamol 650 Injection within 6 hours.
Do not add other medications to the Uphamol 650 Injection solution. Diazepam and chlorpromazine hydrochloride are physically incompatible with Uphamol 650 Injection, therefore do not administer simultaneously.
Uphamol 650 interactions
See also:
What other drugs will affect Uphamol 650?
Uphamol 650 is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize Uphamol 650 [for example, carbamazepine (Tegretol), isoniazid (INH, Nydrazid, Laniazid), rifampin (Rifamate, Rifadin, Rimactane)] reduce the levels of Uphamol 650 and may decrease the action of Uphamol 650. Doses of Uphamol 650 greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for Uphamol 650 to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.
Cholestyramine (Questran) reduces the effect of Uphamol 650 by decreasing its absorption into the body from the intestine. Therefore, Uphamol 650 should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine.
Uphamol 650 doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of Uphamol 650 should be avoided during warfarin therapy
Uphamol 650 side effects
See also:
What are the possible side effects of Uphamol 650?
Applies to Uphamol 650 / caffeine: oral tablet, oral tablet disintegrating
Get emergency medical help if you have any of these signs of an allergic reaction while taking Uphamol 650 / caffeine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
In rare cases, Uphamol 650 may cause a severe skin reaction that can be fatal. This could occur even if you have taken Uphamol 650 in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains Acetaminophen.
Stop using Uphamol 650 and caffeine and call your doctor at once if you have:
-
low fever with nausea, stomach pain, and loss of appetite;
-
dark urine, clay-colored stools; or
-
jaundice (yellowing of the skin or eyes).
Common side effects may include:
-
sleep problems (insomnia); or
-
feeling nervous, irritable, or jittery.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Uphamol 650 contraindications
See also:
What is the most important information I should know about Uphamol 650?
There are many brands and forms of Uphamol 650 available and not all brands are listed on this leaflet.
Do not take more of this medication than is recommended. An overdose of Uphamol 650 can damage your liver or cause death.
Know the amount of Uphamol 650 in the specific product you are taking.
Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take Uphamol 650.
Avoid drinking alcohol. It may increase your risk of liver damage while taking Uphamol 650.
Ask a doctor or pharmacist if it is safe for you to take this medicine if you have liver disease or a history of alcoholism.
Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Uphamol 650 (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much Uphamol 650 which can lead to a fatal overdose. Check the label to see if a medicine contains Acetaminophen or APAP.
Active ingredient matches for Uphamol 650:
Acetaminophen in Malaysia.
List of Uphamol 650 substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Uniserts | |
| Uniserts oral/rectal | |
| Uniserts rectal | |
| Up and Up Temporary Minor Arthritis Pain Relief | |
| Up and Up Temporary Minor Arthritis Pain Relief tablet, film coated, extended release 650 mg/1 (Target Corporation (US)) | |
| Upsanol | |
| Tablet, Effervescent; Oral; Acetaminophen 325 mg | |
| Tablets, Effervescent; Oral; Acetaminophen 325 mg | |
| Upsanol Extra Fort | |
| Tablet, Effervescent; Oral; Acetaminophen 500 mg | |
| Tablets, Effervescent; Oral; Acetaminophen 500 mg | |
| Utragin | |
| Valacin | |
| Valadol (United States) | |
| Valgesic | |
| Valorin | |
| Valorin Extra | |
| Varipan (South Africa) | |
| Veralgina | |
| Verbalem (Mexico) | |
| Verlapyrin N (Germany) | |
| Verpol | |
| Vestil A | |
| Vestil A 5+500 Tablet (Psyco Remedies.) | $ 0.02 |
| Vicdol | |
| Tablet; Oral; Acetaminophen 500 mg | |
| Tablets; Oral; Acetaminophen 500 mg | |
| Vicks Custom Care Body Aches | |
| Liquid; Oral; Acetaminophen 650 mg / 15 ml | |
| Vicks Custom Care Body Aches liquid 650 mg (Procter & Gamble Inc (Canada)) | |
| Vicks Formula 44 Custom Care Body Aches | |
| Viclor Richet | |
| Vimoli Banana | |
| Syrup; Oral; Acetaminophen 125 mg / 5 ml | |
| Vips (Germany) | |
| Viruflu | |
| Vitapap | |
| Western Classics Acetaminophen for Child | |
| Tablet; Oral; Acetaminophen 80 mg | |
| Tablets; Oral; Acetaminophen 80 mg | |
| Wifibrin (Mexico) | |
| XL-Dol Infantil | |
| Tablet, Chewable; Oral; Acetaminophen 80 mg | |
| Tablets, Chewable; Oral; Acetaminophen 80 mg | |
| Xpain | |
| Xpain 250+50+32.5 Capsule (Unimax Laboratories) | $ 0.02 |
| Yacemol Extra Strength | |
| Zatinol (Spain) | |
| Zee Unaspirin ES | |
| Zee Unaspirin Es tablet 500 mg/1 (Zee Medical Inc (US)) | |
| Zuco (Taiwan) | |
| Zuco 120 mL | |
| Zuco 4 L | |
See 2088 substitutes for Uphamol 650 | |
References
- DailyMed. "ACETAMINOPHEN; ASPIRIN; CAFFEINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "acetaminophen". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "acetaminophen". http://www.drugbank.ca/drugs/DB00316 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Uphamol 650 are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Uphamol 650. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported useful
Was the Uphamol 650 drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
| Users | % | ||
|---|---|---|---|
| Not useful | 1 | 100.0% | |
5 consumers reported price estimates
Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Uphamol 650 drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
| Users | % | ||
|---|---|---|---|
| Not expensive | 5 | 100.0% | |
2 consumers reported time for results
To what extent do I have to use Uphamol 650 before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Uphamol 650. To get the time effectiveness of using Uphamol 650 drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 1 day | 2 | 100.0% | |
69 consumers reported age
| Users | % | ||
|---|---|---|---|
| 16-29 | 25 | 36.2% | |
| 6-15 | 16 | 23.2% | |
| 30-45 | 14 | 20.3% | |
| > 60 | 6 | 8.7% | |
| 46-60 | 5 | 7.2% | |
| 1-5 | 2 | 2.9% | |
| < 1 | 1 | 1.4% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
