What is Valorin?
Valorin injection is used together with other medicines (eg, narcotic pain relievers) to relieve moderate to severe pain.
Valorin is used to relieve mild to moderate pain and reduce fever in patients. It does not become habit-forming when taken for a long time. Valorin may cause unwanted effects when taken in large doses, including liver damage.
Valorin is available only with your doctor's prescription.
Valorin indications
Valorin Injection is indicated for
- the management of mild to moderate pain in adult and pediatric patients 2 years and older
- the management of moderate to severe pain with adjunctive opioid analgesics in adult and pediatric patients 2 years and older
- the reduction of fever in adult and pediatric patients.
How should I use Valorin?
Use Valorin injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Valorin injection is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Valorin injection at home, a health care provider will teach you how to use it. Be sure you understand how to use Valorin injection. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not mix other medicines (especially chlorpromazine or diazepam) in the same container or IV line as Valorin injection. Contact your health care provider if you have any questions about how to give Valorin injection with other medicines.
- Do not use Valorin injection if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Use Valorin injection within 6 hours after opening.
- If you miss a dose of Valorin injection and you are using it regularly, use it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Valorin injection.
Uses of Valorin in details
This drug is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever.
How to use Valorin Jr
Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.
There are many brands and forms of Valorin available. Read the dosing instructions carefully for each product because the amount of Valorin may be different between products. Do not take more Valorin than recommended.
If you are giving Valorin to a child, be sure you use a product that is meant for children. Use your child's weight to find the right dose on the product package. If you don't know your child's weight, you can use their age.
For suspensions, shake the medication well before each dose. Some liquids do not need to be shaken before use. Follow all directions on the product package. Measure the liquid medication with the provided dose-measuring spoon/dropper/syringe to make sure you have the correct dose. Do not use a household spoon.
For rapidly-dissolving tablets, chew or allow to dissolve on the tongue, then swallow with or without water. For chewable tablets, chew thoroughly before swallowing.
Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
For effervescent tablets, dissolve the dose in the recommended amount of water, then drink.
Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well.
Do not take this medication for fever for more than 3 days unless directed by your doctor. For adults, do not take this product for pain for more than 10 days (5 days in children) unless directed by your doctor. If the child has a sore throat (especially with high fever, headache, or nausea/vomiting), consult the doctor promptly.
Tell your doctor if your condition persists or worsens or if you develop new symptoms. If you think you may have a serious medical problem, get medical help right away.
Valorin description
Valorin (with the Optizorb formulation) also contains the following excipients: Pregelatinized maize starch, calcium carbonate, alginic acid, crospovidone, povidone, magnesium stearate, colloidal anhydrous silica, parahydroxybenzoates (sodium methyl, ethyl and propyl), OPADRY YS-1-7003 white, carnauba wax, purified water.
It contains no sugar, lactose or gluten.
Valorin dosage
General Dosing Information
Valorin Injection may be given as a single or repeated dose for the treatment of acute pain or fever. No dose adjustment is required when converting between oral Valorin and Valorin Injection dosing in adults and adolescents who weigh 50 kg and above. Calculated maximum daily dose of Valorin is based on all routes of administration (i.e., intravenous, oral, and rectal) and all products containing Valorin. Exceeding the maximum mg/kg daily dose of Valorin as described in Tables 1 to 3 may result in hepatic injury, including the risk of liver failure and death. To avoid the risk of overdose, ensure that the total amount of Valorin from all routes and from all sources does not exceed the maximum recommended dose.
Recommended
Dosage: Adults and Adolescents
Adults and adolescents weighing 50 kg and over: the recommended dosage of Valorin Injection is 1,000 mg every 6 hours or 650 mg every 4 hours, with a maximum single dose of Valorin Injection of 1,000 mg, a minimum dosing interval of 4 hours, and a maximum daily dose of Valorin of 4,000 mg per day (includes all routes of administration and all Valorin-containing products including combination products).
Adults and adolescents weighing under 50 kg: the recommended dosage of Valorin Injection is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Valorin Injection of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of Valorin of 75 mg/kg per day (includes all routes of administration and all Valorin-containing products including combination products).
| Age group | Dose given every 4 hours | Dose given every 6 hours | Maximum single dose | Maximum total daily dose of Valorin (by all routes) |
|---|---|---|---|---|
| Adults and adolescents (13 years and older) weighing ≥ 50 kg | 650 mg | 1,000 mg | 1,000 mg | 4,000 mg in 24 hours |
| Adults and adolescents (13 years and older) weighing < 50 kg | 12.5 mg/kg | 15 mg/kg | 15 mg/kg (up to 750 mg) | 75 mg/kg in 24 hours (up to 3,750 mg) |
Recommended
Dosage: Children
Children 2 to 12 years of age: the recommended dosage of Valorin Injection is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Valorin Injection of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of Valorin of 75 mg/kg per day.
| Age group | Dose given every 4 hours | Dose given every 6 hours | Maximum single dose | Maximum total daily dose of Valorin (by all routes) |
| Children 2 to 12 years of age | 12.5 mg/kg | 15 mg/kg | 15 mg/kg (up to 750 mg) | 75 mg/kg in 24 hours (up to 3,750 mg) |
Recommended Dosage for Treatment of Fever in Neonates and Infants
Neonates, including premature neonates born at ≥ 32 weeks gestational age, up to 28 days chronological age: the recommended dosage of Valorin is 12.5 mg/kg every 6 hours, to a maximum daily dose of Valorin of 50 mg/kg per day, with a minimum dosing interval of 6 hours.
Infants 29 days to 2 years of age: the recommended dosage of Valorin is 15 mg/kg every 6 hours, to a maximum daily dose of Valorin of 60 mg/kg per day, with a minimum dosing interval of 6 hours.
| Age group | Dose given every 6 hours | Maximum total daily dose of Valorin (by all routes) |
| Neonates (birth to 28 days) | 12.5 mg/kg | 50 mg/kg |
| Infants (29 days to 2 years) | 15 mg/kg | 60 mg/kg |
Instructions for
Intravenous Administration
For adult and adolescent patients weighing ≥ 50 kg requiring 1,000 mg doses of Valorin Injection, administer the dose by inserting a vented intravenous set through the septum of the 100 mL vial. Valorin Injection may be administered without further dilution. Examine the container contents before dose preparation or administering. DO NOT USE if particulate matter or discoloration is observed. Administer the contents of the vial intravenously over 15 minutes. Use aseptic technique when preparing Valorin Injection for intravenous infusion. Do not add other medications to the Valorin Injection vial or infusion device.
For doses less than 1,000 mg, the appropriate dose must be withdrawn from the container and placed into a separate container prior to administration. Using aseptic technique, withdraw the appropriate dose (650 mg or weight-based) from an intact sealed Valorin Injection container and place the measured dose in a separate empty, sterile container (e.g., glass bottle, plastic intravenous container, or syringe) for intravenous infusion to avoid the inadvertent delivery and administration of the total volume of the commercially available container. The entire 100 mL container of Valorin Injection is not intended for use in patients weighing less than 50 kg. Valorin Injection is supplied in a single-dose container and the unused portion must be discarded.
Place small volume pediatric doses up to 60 mL in volume in a syringe and administer over 15 minutes using a syringe pump.
Monitor the end of the infusion in order to prevent the possibility of an air embolism, especially in cases where the Valorin Injection infusion is the primary infusion.
Once the container seal has been penetrated, or the contents transferred to another container, administer the dose of Valorin Injection within 6 hours.
Do not add other medications to the Valorin Injection solution. Diazepam and chlorpromazine hydrochloride are physically incompatible with Valorin Injection, therefore do not administer simultaneously.
Valorin interactions
See also:
What other drugs will affect Valorin?
Valorin is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize Valorin [for example, carbamazepine (Tegretol), isoniazid (INH, Nydrazid, Laniazid), rifampin (Rifamate, Rifadin, Rimactane)] reduce the levels of Valorin and may decrease the action of Valorin. Doses of Valorin greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for Valorin to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.
Cholestyramine (Questran) reduces the effect of Valorin by decreasing its absorption into the body from the intestine. Therefore, Valorin should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine.
Valorin doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of Valorin should be avoided during warfarin therapy
Valorin side effects
See also:
What are the possible side effects of Valorin?
Applies to Valorin / caffeine: oral tablet, oral tablet disintegrating
Get emergency medical help if you have any of these signs of an allergic reaction while taking Valorin / caffeine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
In rare cases, Valorin may cause a severe skin reaction that can be fatal. This could occur even if you have taken Valorin in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains Acetaminophen.
Stop using Valorin and caffeine and call your doctor at once if you have:
-
low fever with nausea, stomach pain, and loss of appetite;
-
dark urine, clay-colored stools; or
-
jaundice (yellowing of the skin or eyes).
Common side effects may include:
-
sleep problems (insomnia); or
-
feeling nervous, irritable, or jittery.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Valorin contraindications
See also:
What is the most important information I should know about Valorin?
There are many brands and forms of Valorin available and not all brands are listed on this leaflet.
Do not take more of this medication than is recommended. An overdose of Valorin can damage your liver or cause death.
Know the amount of Valorin in the specific product you are taking.
Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take Valorin.
Avoid drinking alcohol. It may increase your risk of liver damage while taking Valorin.
Ask a doctor or pharmacist if it is safe for you to take this medicine if you have liver disease or a history of alcoholism.
Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Valorin (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much Valorin which can lead to a fatal overdose. Check the label to see if a medicine contains Acetaminophen or APAP.
Active ingredient matches for Valorin:
Paracetamol in United States.
List of Valorin substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Valoflam P | |
| Valoflam P 10 mg/500 mg Tablet (Sigma Laboratories Pvt Ltd) | $ 0.04 |
| Valorin Extra | |
| Value Choice Paracetamol (Australia) | |
| Value Health Paracetamol (United Kingdom) | |
| Vardol Plus (India) | |
| Vardol Plus 50+500 Tablet (Zota Pharmaceuticals (Zota Healthcare Pvt Ltd)) | $ 0.06 |
| VARDOL PLUS tab 10's (Zota Pharmaceuticals (Zota Healthcare Pvt Ltd)) | $ 0.60 |
| Varipan (South Africa) | |
| Varkof Q Tablet | |
| Varkof Q Tablet (Zota Healthcare Pvt. Ltd.) | $ 0.02 |
| Vasograin Tablet | |
| Vasograin Tablet (Le Sante (Cadila Pharmaceuticals Ltd.)) | $ 0.04 |
| Veclo P | |
| Veclo P 100+500 Tablet (V&B Healthcare) | $ 0.07 |
| Vectra P | |
| Vectra P 500+10 Tablet (Cipla Limited) | $ 0.04 |
| Veerest Tablet | |
| Veerest Tablet (Vivid Labs Pvt Ltd) | $ 0.01 |
| Veezox | |
| Veezox 325+250+50 Tablet (Vivid Labs Pvt Ltd) | $ 0.04 |
| Veflam NP | |
| Veflam NP 100+500 Tablet (Vega Laboratories Pvt. Ltd.) | $ 0.03 |
| VEFLAM NP TABLET 1 strip / 10 tablets each (Vega Laboratories Pvt. Ltd.) | $ 0.36 |
| Veflam NP Tablet (Vega Laboratories Pvt. Ltd.) | $ 0.04 |
| Vemol (Thailand) | |
| Vemol 325 mg x 1, 000's (Oncare Life Sciences (Adley Formulation)) | $ 5.76 |
| Vemol 500 mg x 1, 000's (Oncare Life Sciences (Adley Formulation)) | $ 7.58 |
| Vemol 120 mg/5 mL x 60 mL (Oncare Life Sciences (Adley Formulation)) | $ 0.38 |
| Vemol 120 mg/5 mL x 1 gal (Oncare Life Sciences (Adley Formulation)) | $ 11.36 |
| 0.5 % w/v x 5ml (Oncare Life Sciences (Adley Formulation)) | $ 0.30 |
| Vemol 0.5 % w/v EYE DPS / 5ml (Oncare Life Sciences (Adley Formulation)) | $ 0.30 |
| Vemol Eye 5 ml Drop (Oncare Life Sciences (Adley Formulation)) | $ 0.30 |
| VEMOL eye drops 0.5 % w/v x 5ml (Oncare Life Sciences (Adley Formulation)) | $ 0.30 |
| Vemolid Plus | |
| Vemolid Plus 100+500 Tablet (Vision Biotech) | $ 0.05 |
| Venim P | |
| Venim P 100+500 Tablet (PMV Healthcare) | $ 0.03 |
| Venmol (India) | |
| 500 mg x 10's (Vencare Formulations Pvt Ltd) | $ 0.10 |
| 650 mg x 10's (Vencare Formulations Pvt Ltd) | $ 0.16 |
| Venmol 60 ml Suspension (Vencare Formulations Pvt Ltd) | $ 0.02 |
| Venmol 500mg DT-TAB / 10 (Vencare Formulations Pvt Ltd) | $ 0.10 |
| Venmol 650mg DT-TAB / 10 (Vencare Formulations Pvt Ltd) | $ 0.16 |
| VENMOL dispertab 500 mg x 10's (Vencare Formulations Pvt Ltd) | $ 0.10 |
| VENMOL dispertab 650 mg x 10's (Vencare Formulations Pvt Ltd) | $ 0.16 |
| Venmol DT | |
| Venmol DT 650 mg Tablet (Vencare Formulations Pvt Ltd) | $ 0.02 |
| Venmol DT 500 mg Tablet (Vencare Formulations Pvt Ltd) | $ 0.01 |
| VENMOL SUS (India) | |
| 125 mg x 5 mL x 60ml | $ 0.18 |
| 250 mg x 5 mL x 60ml | $ 0.28 |
| Venmol Sus 125mg x 5mL SUSP / 60ml | $ 0.18 |
| Venmol Sus 250mg x 5mL SUSP / 60ml | $ 0.28 |
| Venmol Sus 125mg x 5mL SUSP / 60ml | $ 0.18 |
| Venmol Sus 250mg x 5mL SUSP / 60ml | $ 0.28 |
| VENMOL SUSP (India) | |
| VENMOL SUSP oral susp 125 mg x 5 mL x 60ml (Vencare) | $ 0.18 |
See 11725 substitutes for Valorin | |
References
- DailyMed. "ACETAMINOPHEN; ASPIRIN; CAFFEINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "acetaminophen". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "acetaminophen". http://www.drugbank.ca/drugs/DB00316 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Valorin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Valorin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
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Information checked by Dr. Sachin Kumar, MD Pharmacology
