What is Uro-Nebacetin?
Uro-Nebacetin is an antibiotic that fights bacteria in the body.
Uro-Nebacetin is used to reduce the risk of infection during surgery of your intestines. Uro-Nebacetin is also used to reduce the symptoms of hepatic coma.
Uro-Nebacetin may also be used for purposes not listed in this medication guide.
Uro-Nebacetin indications
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Uro-Nebacetin Sulfate tablets and other antibacterial drugs, Uro-Nebacetin Sulfate tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Suppression of Intestinal Bacteria
Uro-Nebacetin Sulfate tablets are indicated as adjunctive therapy as part of a regimen for the suppression of the normal bacterial flora of the bowel, e.g., preoperative preparation of the bowel. It is given concomitantly with erythromycin enteric-coated base.
Hepatic Coma (Portal-Systemic Encephalopathy)
Uro-Nebacetin Sulfate has been shown to be effective adjunctive therapy in hepatic coma by reduction of the ammonia-forming bacteria in the intestinal tract. The subsequent reduction in blood ammonia has resulted in neurologic improvement.
How should I use Uro-Nebacetin?
Use Uro-Nebacetin solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Uro-Nebacetin solution by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Take Uro-Nebacetin solution with plenty of water to avoid dehydration.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Take Uro-Nebacetin solution on a regular schedule to get the most benefit from it.
- To clear up your infection completely, use Uro-Nebacetin solution for the full course of treatment. Keep using it even if you feel better in a few days.
- If you miss a dose of Uro-Nebacetin solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your health care provider.
Ask your health care provider any questions you may have about how to use Uro-Nebacetin solution.
Uses of Uro-Nebacetin in details
Oral Uro-Nebacetin is used before the operation of the gut to kill the bacteria which normally live in the gut that may cause a serious infection and in treatment of patients with coma due to liver disease (hepatic coma).
Uro-Nebacetin description
A component of Uro-Nebacetin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). Uro-Nebacetin is a bactericidal aminoglycoside antibiotic that binds to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and acceptor tRNA sites and results in the production of non-functional or toxic peptides.
Uro-Nebacetin dosage
Uro-Nebacetin Dosage
Generic name: Uro-Nebacetin SULFATE 87.5mg in 5mL
Dosage form: oral solution
See also:
- Uro-Nebacetin
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
To minimize the risk of toxicity use the lowest possible dose and the shortest possible treatment period to control the condition. Treatment for periods longer than two weeks is not recommended.
Hepatic coma
For use as an adjunct in the management of hepatic coma, the recommended dose is 4 to 12 grams per day given in the following regimen:
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Withdraw protein from diet. Avoid use of diuretic agents.
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Give supportive therapy including blood products, as indicated.
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Give Uro-Nebacetin
Oral Solution in doses of four to twelve grams of Uro-Nebacetin sulfate per day in divided doses.
Treatment should be continued over a period of five to six days during which time protein should be returned incrementally to the diet.
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If less potentially toxic drugs cannot be used for chronic hepatic insufficiency, Uro-Nebacetin sulfate in doses of up to four grams daily may be necessary. The risks for the development of Uro-Nebacetin induced toxicity progressively increase when the treatment must be extended to preserve the life of a patient with hepatic encephalopathy who has failed to fully respond. Frequent periodic monitoring of these patients to ascertain the presence of drug toxicity is mandatory. Also, Uro-Nebacetin serum concentrations should be monitored to avoid potentially toxic levels. The benefits to the patient should be weighed against the risks of nephrotoxicity, permanent ototoxicity and neuromuscular blockade following the accumulation of Uro-Nebacetin in the tissues.
More about Uro-Nebacetin (Uro-Nebacetin)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- En Espanol
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Consumer resources
- Uro-Nebacetin solution
- Uro-Nebacetin
- Uro-Nebacetin (Advanced Reading)
- Other brands: Neo-Tab
Professional resources
- Uro-Nebacetin (FDA)
- Uro-Nebacetin Sulfate (AHFS Monograph)
Related treatment guides
- Bowel Preparation
- Diarrhea
- Hepatic Coma
- Hepatic Encephalopathy
Uro-Nebacetin interactions
See also:
What other drugs will affect Uro-Nebacetin?
Caution should be taken in concurrent or serial use of other neurotoxic and/ or nephrotoxic drugs because of possible enhancement of the nephrotoxicity and/or ototoxicity of Uro-Nebacetin.
Caution should also be taken in concurrent or serial use of other aminoglycosides and polymyxins because they may enhance Uro-Nebacetin's nephrotoxicity and/or ototoxicity and potentiate Uro-Nebacetin sulfate's neuromuscular blocking effects.
Oral Uro-Nebacetin inhibits the gastrointestinal absorption of penicillin V, oral vitamin B-12, methotrexate and 5-fluorouracil. The gastrointestinal absorption of digoxin also appears to be inhibited. Therefore, digoxin serum levels should be monitored.
Oral Uro-Nebacetin sulfate may enhance the effect of coumarin in anticoagulants by decreasing vitamin K availability.
Uro-Nebacetin side effects
See also:
What are the possible side effects of Uro-Nebacetin?
Applies to Uro-Nebacetin: oral solution, oral tablet
In addition to its needed effects, some unwanted effects may be caused by Uro-Nebacetin (the active ingredient contained in Uro-Nebacetin). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Uro-Nebacetin:
Rare
- Any loss of hearing
- clumsiness
- diarrhea
- difficulty in breathing
- dizziness
- drowsiness
- greatly decreased frequency of urination or amount of urine
- increased amount of gas
- increased thirst
- light-colored, frothy, fatty-appearing stools
- ringing or buzzing or a feeling of fullness in the ears
- skin rash
- unsteadiness
- weakness
Minor Side Effects
Some of the side effects that can occur with Uro-Nebacetin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
- Irritation or soreness of the mouth or rectal area
- nausea or vomiting
Uro-Nebacetin contraindications
See also:
What is the most important information I should know about Uro-Nebacetin?
You should not take this medicine if you are allergic to Uro-Nebacetin or similar antibiotics such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), paromomycin (Humatin, Paromycin), streptomycin, or tobramycin (Nebcin, Tobi).
You should not take Uro-Nebacetin if you have ulcerative colitis, Crohn's disease, a blockage in your intestines, or other inflammatory bowel disease.
Do not use Uro-Nebacetin if you are pregnant. It could harm the unborn baby.
Before you take Uro-Nebacetin, tell your doctor if you have kidney disease, myasthenia gravis, or Parkinson's disease.
Never take Uro-Nebacetin in larger amounts than recommended, or for longer than 2 weeks. High doses or long-term use of Uro-Nebacetin can cause serious kidney problems, or hearing loss that may not be reversible. The longer you take Uro-Nebacetin, the more likely you are to develop these serious side effects.
To be sure this medication is not causing harmful effects, your kidney function, and your nerve and muscle function will need to be tested often. You may also need hearing tests. Uro-Nebacetin can have long lasting effects on your body. Do not miss any follow up visits to your doctor for blood or urine tests.
Uro-Nebacetin can harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. Before using Uro-Nebacetin, tell your doctor about all other medicines you use. Many other drugs (including some over-the-counter medicines) can be harmful to the kidneys.
If you are being treated for hepatic coma, avoid eating foods that are high in protein. Follow your doctor's instructions about any other restrictions on food, beverages, or activity.
Active ingredient matches for Uro-Nebacetin:
Neomycin in Germany.
List of Uro-Nebacetin substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| New-cin (Pakistan) | |
| Nineka (Mexico) | |
| Nivemycin (Greece, United Kingdom) | |
| Tablet; Oral; Neomycin Sulphate 500 mg (Ifet) | |
| Océmycine (France) | |
| Ophtalkan (France) | |
| Opthodex N | |
| Opthodex N Eye 5 ml Drop (Optho Remedies Pvt.Ltd.) | $ 0.11 |
| OPTHODEX N 0.5%/0.1% DROPS 1 packet / 5 ML drop each (Optho Remedies Pvt.Ltd.) | $ 0.11 |
| Opthodex N Eye Drop (Optho Remedies Pvt.Ltd.) | $ 0.11 |
| Polnedex (Vietnam) | |
| Polnedex 1 Bottle 5 mL | |
| Qcderm RF | |
| Qcderm RF Skin 5 gm Cream (Khandelwal Laboratories Pvt Ltd.) | $ 0.27 |
| Qcderm RF 25 gm Cream (Khandelwal Laboratories Pvt Ltd.) | $ 0.90 |
| Qcderm RF Skin 10 gm Cream (Khandelwal Laboratories Pvt Ltd.) | $ 0.48 |
| Raspisons (Mexico) | |
| Siguent Neomycin (Australia) | |
| Sofratulle (Japan) | |
| Solubin N | |
| Solubin N Eye 3.5 gm Drop (Perk Pharmaceuticals Ltd.) | $ 0.12 |
| Solubin N Eye 5 ml Drop (Perk Pharmaceuticals Ltd.) | $ 0.15 |
| SOLUBIN N DROPS 1 packet / 5 ML drop each (Perk Pharmaceuticals Ltd.) | $ 0.23 |
| SOLUBIN N OINTMENT 1 tube / 5 GM ointment each (Perk Pharmaceuticals Ltd.) | $ 0.20 |
| Solubin N Drop (Perk Pharmaceuticals Ltd.) | $ 0.23 |
| Solubin N Ointment (Perk Pharmaceuticals Ltd.) | $ 0.04 |
| Stemin N | |
| Stemin N Eye 5 ml Drop (Ind-Swift Limited) | $ 0.09 |
| Sulfato de Neomicina Prati Donad (Brazil) | |
| Sunsulf | |
| Sunsulf Skin 10 gm Powder (Sunways India Pvt. Ltd.) | $ 0.00 |
| Swisscort (Taiwan) | |
| Swisscort 5 g | |
| Taurdex N | |
| Taurdex N Eye 5 ml Drop (Taurus Laboratories Pvt. Ltd.) | $ 0.10 |
| Treda (Mexico) | |
| Suspension; Oral; Kaolin Colloidal 100 mg; Neomycin Sulfate 7.33 mg; Pectin Citrus 7 mg / ml (Sanfer) | |
| Tablet; Oral; Kaolin Colloidal 280 mg; Neomycin Sulfate 129 mg; Pectin Citrus 30 mg (Sanfer) | |
| Tryderm | |
| Tryderm Skin 5 gm Cream (Universal Pharmaceuticals) | $ 0.25 |
| Unguentum Neomycini (Poland) | |
| Upha Neomycin (Malaysia) | |
| Upha Neomycin 0.5 % x 15 g (CCM Pharmaceuticals) | |
| Upha Neomycin cream 0.5 % 15 g x 1's (CCM Pharmaceuticals) | |
| Uro-Beniktol N (Switzerland) | |
| Uro-Nebacetin N (Germany) | |
| Vagicillin (Germany) | |
| VEBATE (India) | |
| 15g (Salvus) | |
| Vebate Neomycin 0.5 %, beclometasonedipropionate 0.025 %, clotrimazole 1 %. OINT / 15g (Salvus) | |
| VEBATE oint 15g (Salvus) | |
| Vebate Neomycin 0.5 %, beclometasonedipropionate 0.025 %, clotrimazole 1 %. OINT / 15g (Salvus) | |
| Vonamycin Powder V | |
| Zevate | |
| Zevate Skin 20 gm Cream (Zee Laboratories Ltd) | $ 0.34 |
See 287 substitutes for Uro-Nebacetin | |
References
- DailyMed. "HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "neomycin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "neomycin". http://www.drugbank.ca/drugs/DB00452 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Uro-Nebacetin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Uro-Nebacetin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
