What is V-Cil?
Penicillins are used to treat infections caused by bacteria. They work by killing the bacteria or preventing their growth.
There are several different kinds of penicillins. Each is used to treat different kinds of infections. One kind of V-Cil usually may not be used in place of another. In addition, penicillins are used to treat bacterial infections in many different parts of the body. They are sometimes given with other antibacterial medicines (antibiotics). Some of the penicillins may also be used for other problems as determined by your doctor. However, none of the penicillins will work for colds, flu, or other virus infections.
Penicillins are available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, penicillins are used in certain patients with the following medical conditions:
- Chlamydia infections in pregnant women—Amoxicillin and ampicillin
- Gas gangrene—V-Cil G
- Helicobacter pylori-associated gastritis or peptic ulcer disease—Amoxicillin
- Leptospirosis—Ampicillin and V-Cil G
- Lyme disease—Amoxicillin and V-Cil
- Typhoid fever—Amoxicillin and ampicillin
V-Cil indications
To reduce the development of drug-resistant bacteria and maintain the effectiveness of V-Cil Potassium and other antibacterial drugs, V-Cil Potassium should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
V-Cil Potassium tablets are indicated in the treatment of mild to moderately severe infections due to V-Cil G-sensitive microorganisms. Therapy should be guided by bacteriologic studies (including sensitivity tests) and by clinical response.
NOTE: Severe pneumonia, empyema, bacteremia, pericarditis, meningitis, and arthritis should not be treated with V-Cil during the acute stage. Indicated surgical procedures should be performed.
The following infections will usually respond to adequate dosage of V-Cil.
Streptococcal Infections (without bacteremia)
Mild-to-moderate infections of the upper respiratory tract, scarlet fever, and mild erysipelas.
NOTE: Streptococci in groups A, C, G, H, L, and M are very sensitive to V-Cil. Other groups, including group D (enterococcus), are resistant.
Pneumococcal Infections
Mild to moderately severe infections of the respiratory tract.
Staphylococcal infections – V-Cil G-sensitive
Mild infections of the skin and soft tissues.
NOTE: Reports indicate an increasing number of strains of staphylococci resistant to V-Cil G, emphasizing the need for culture and sensitivity studies in treating suspected staphylococcal infections.
Fusospirochetosis (Vincent’s gingivitis and pharyngitis)
Mild to moderately severe infections of the oropharynx usually respond to therapy with oral V-Cil.
NOTE: Necessary dental care should be accomplished in infections involving the gum tissue.
Medical conditions in which oral V-Cil therapy is indicated as prophylaxis: For the prevention of recurrence following rheumatic fever and/or chorea: Prophylaxis with oral V-Cil on a continuing basis has proven effective in preventing recurrence of these conditions.
Although no controlled clinical efficacy studies have been conducted, V-Cil has been suggested by the American Heart Association and the American Dental Association for use as an oral regimen for prophylaxis against bacterial endocarditis in patients who have congenital heart disease or rheumatic or other acquired valvular heart disease when they undergo dental procedures and surgical procedures of the upper respiratory tract1.
Oral V-Cil should not be used in those patients at particularly high risk for endocarditis (e.g., those with prosthetic heart valves or surgically constructed systemic pulmonary shunts). V-Cil should not be used as adjunctive prophylaxis for genitourinary instrumentation or surgery, lower-intestinal tract surgery, sigmoidoscopy, and childbirth. Since it may happen that alpha hemolytic streptococci relatively resistant to V-Cil may be found when patients are receiving continuous oral V-Cil for secondary prevention of rheumatic fever, prophylactic agents other than V-Cil may be chosen for these patients and prescribed in addition to their continuous rheumatic fever prophylactic regimen.
NOTE: When selecting antibiotics for the prevention of bacterial endocarditis, the physician or dentist should read the full joint statement of the American Heart Association and the American Dental Association1.
How should I use V-Cil?
Use V-Cil as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- V-Cil is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using V-Cil at home, a health care provider will teach you how to use it. Be sure you understand how to use V-Cil. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use V-Cil if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- V-Cil works best if it is given at the same time each day.
- V-Cil is injected into a muscle. V-Cil should not be injected into or near an artery or vein.
- To clear up your infection completely, use V-Cil for the full course of treatment. Keep using it even if you feel better in a few days.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of V-Cil and you are using it regularly, use it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use V-Cil.
Uses of V-Cil in details
Use: Labeled Indications
Fusospirochetosis (Vincent gingivitis and pharyngitis): Treatment of fusospirochetosis (Vincent gingivitis and pharyngitis), in conjunction with dental care for infections involving gum tissue.
Pneumococcal infections: Treatment of mild to moderately severe pneumococcal respiratory tract infections, including otitis media.
Rheumatic fever and/or chorea prophylaxis: Prophylaxis (chronic, secondary) of rheumatic fever and/or chorea.
Staphylococcal infections (V-Cil G-sensitive): Treatment of mild infections of the skin and soft tissues.
Streptococcal infections (without bacteremia): Treatment of mild to moderate streptococcal infections of the upper respiratory tract, scarlet fever, and mild erysipelas.
Off Label Uses
Actinomycosis
Data from a limited number of clinical studies suggest that V-Cil potassium may be beneficial for the treatment of actinomycosis after initial surgical intervention and IV therapy with V-Cil G (if clinically indicated).
Streptococcus (group A) chronic carrier
Based on the Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis, V-Cil potassium given to chronic carriers of group A streptococcal is effective and recommended in the management of this condition.
V-Cil description
A broad-spectrum V-Cil antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.
V-Cil dosage
The dosage of V-Cil should be determined according to the sensitivity of the causative microorganism and the severity of infection, and adjusted to the clinical response of the patient.
The usual dosage recommendations for adults and children 12 years and over are as follows:
Streptococcal Infections
Mild to moderately severe - of the upper respiratory tract and including scarlet fever and erysipelas: 125 to 250 mg (200,000 to 400,000 units) every 6 to 8 hours for 10 days.
Pneumococcal Infections
Mild to moderately severe - of the respiratory tract, including otitis media: 250 to 500 mg (400,000 to 800,000 units) every 6 hours until the patient has been afebrile for at least 2 days.
Staphylococcal Infections
Mild infections of skin and soft tissue (culture and sensitive tests should be performed): 250 to 500 mg (400,000 to 800,000 units) every 6 to 8 hours.
Fusospirochetosis (Vincent’s infection) of the oropharynx. Mild to moderately severe infections: 250 to 500 mg (400,000 to 800,000 units) every 6 to 8 hours.
For the prevention of recurrence following rheumatic fever and/or chorea: 125 mg to 250 mg (200,000 to 400,000 units) twice daily on a continuing basis.
For prophylaxis against bacterial endocarditis1 in patients with congenital heart disease or rheumatic or other acquired valvular heart disease when undergoing dental procedures or surgical procedures of the upper respiratory tract: 2 gram of V-Cil (1 gram for children under 60 lbs.) 1 hour before the procedure, and then, 1 gram (500 mg for children under 60 lbs.) 6 hours later.
V-Cil interactions
See also:
What other drugs will affect V-Cil?
Amoxicillin may decrease the effectiveness of contraceptives for oral administration.
With the simultaneous use of V-Cil Vista Health Care with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) appears synergies; with bacteriostatic antibiotic (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulphonamide) - antagonism.
Amoxicillin increases the effects of indirect anticoagulants inhibiting intestinal microflora, reduces the synthesis of vitamin K and prothrombin index.
Amoxicillin reduces the effect of drugs, in the process of metabolism that produce PABA.
Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs decrease the tubular secretion of amoxicillin, which can be accompanied by an increase in its concentration in blood plasma.
Antacids, glucosamine, laxatives, aminoglycosides, slow down and reduce, and ascorbic acid increases the absorption of amoxicillin.
With the combined use of amoxicillin and clavulanic acid pharmacokinetics of both components unchanged.
V-Cil side effects
See also:
What are the possible side effects of V-Cil?
Applies to V-Cil potassium: capsule, powder for solution, powder for suspension, solution, suspension, syrup, tablet, tablet for suspension, tablet chewable, tablet extended release
As well as its needed effects, V-Cil potassium may cause unwanted side effects that require medical attention.
Stop taking V-Cil potassium and get emergency help immediately if any of the following effects occur:
Less common:
- Fast or irregular breathing
- fever
- joint pain
- lightheadedness or fainting (sudden)
- puffiness or swelling around the face
- red, scaly skin
- shortness of breath
- skin rash, hives, itching
Major Side Effects
If any of the following side effects occur while taking V-Cil potassium, check with your doctor immediately:
Rare
- Abdominal or stomach cramps and pain (severe)
- abdominal tenderness
- convulsions (seizures)
- decreased amount of urine
- diarrhea (watery and severe), which may also be bloody
- mental depression
- nausea and vomiting
- pain at place of injection
- sore throat and fever
- unusual bleeding or bruising
- yellow eyes or skin
- Agitation or combativeness
- anxiety
- confusion
- fear of impending death
- feeling, hearing, or seeing things that are not real
Minor Side Effects
Some V-Cil potassium side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:
More common:
- Diarrhea (mild)
- headache
- sore mouth or tongue
- vaginal itching and discharge
- white patches in the mouth and/or on the tongue
V-Cil contraindications
See also:
What is the most important information I should know about V-Cil?
A history of a previous hypersensitivity reaction to any of the penicillins is a contraindication. V-Cil is also contraindicated in infections caused by penicillinase-producing organisms.
Active ingredient matches for V-Cil:
List of V-Cil substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Pfizerpen | |
| Injectable; Injection; Penicillin G Potassium 20, 000, 000 units (Pfizer) | |
| Pfizerpen VK | |
| Tablet; Oral; Penicillin V Potassium 250 mg | |
| Tablet; Oral; Penicillin V Potassium 500 mg | |
| Phenomycilline | |
| Phenopenicillin | |
| PVF (Canada) | |
| Suspension; Oral; Penicillin V Benzathine 250, 000 units / 5 ml (Frosst) | |
| Suspension; Oral; Penicillin V Benzathine 500, 000 units / 5 ml (Frosst) | |
| Tablet; Oral; Penicillin V Potassium 500, 000 units (Frosst) | |
| PVF-K 500 | |
| Tablet; Oral; Penicillin V Potassium 500, 000 units | |
| PVFK (Canada) | |
| PVK (Australia) | |
| Rafapen Mega (Israel) | |
| Caplets; Oral; Penicillin V Potassium 1 g (Rafa) | |
| Rafapen VK | |
| Tablet; Oral; Penicillin V Potassium 500 mg | |
| Rafapen VK Forte | |
| Syrup; Oral; Penicillin V Potassium 250 mg / 5 ml | |
| Rivopen-V (Switzerland) | |
| Robicillin | |
| Rolab-Pen-V-K (South Africa) | |
| Roscopenin (Sweden) | |
| Servipen-V (Thailand) | |
| Stabicillin | |
| Tablet, Film-Coated; Oral; Penicillin V Potassium 1 MIU | |
| Stabicilline Tablets | |
| Tablet, Film-Coated; Oral; Penicillin V Potassium 1 MIU | |
| Stabillin V-K (United Kingdom) | |
| Star-Pen (Austria) | |
| Tablet, Film-Coated; Oral; Penicillin V Potassium 1 g (Sandoz) | |
| Uticillin VK | |
| Tablet; Oral; Penicillin V Potassium 250 mg | |
| Tablet; Oral; Penicillin V Potassium 500 mg | |
| V Cillin K 1831 | |
| Tablet; Oral; Penicillin V Potassium 250 mg | |
| V-Cil-K | |
| V-Cylina | |
| V-Cyline | |
| V-Pen Ped Forte | |
| V-Tablopen | |
| VC-K (Canada) | |
| Vebecillin | |
| Veekay (South Africa) | |
| Veetids '125' | |
| Veetids '250' | |
| Veetids '500' | |
| Veetids Solution | |
| Veetids Tablets | |
| Vegacillin (Hungary) | |
| Vepenicillin (Sweden) | |
See 174 substitutes for V-Cil | |
References
- DailyMed. "PENICILLIN V POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "penicillin v". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "penicillin v". http://www.drugbank.ca/drugs/DB00417 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for V-Cil are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking V-Cil. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
