Vacanyl Uses

• Vacanyl indications
• Uses of Vacanyl in details
• Vacanyl description
• Vacanyl dosage
• Vacanyl interactions
• Vacanyl side effects
• Vacanyl contraindications

What is Vacanyl?

Vacanyl injection is used to prevent bronchospasm in patients 12 years of age and older with asthma, bronchitis, emphysema, and other lung diseases.

Vacanyl belongs to the family of medicines known as bronchodilators. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

Vacanyl is available only with your doctor's prescription.

Vacanyl indications

Oral

Acute bronchospasm

Adult: Initially, 2.5 mg or 3 mg tid, up to 5 mg tid as necessary. As modified-release tab: 5 mg or 7.5 mg bid.

Child: <12 yr Initially, 0.05 mg/kg/dose tid, increase gradually as required. Max: 5 mg/day; 12-15 yr 2.5 mg tid; >15 yr Same as adult dose.

Inhalation

Acute bronchospasm

Adult: As metered-dose powd inhaler: 250-500 mcg as required. Max: 2,000 mcg daily.

Parenteral

Severe bronchospasm

Adult: 250-500 mcg up to 4 times daily by SC, IM or IV inj, or by IV infusion as a soln containing 3-5 mcg/mL at a rate of 0.5-1 mL/min.

Child: 2-15 yr 0.01 mg/kg. Max: 0.3 mg/dose.

Reconstitution: Add 10 mL of Vacanyl soln for inj to 40 mL of dextrose 5% if using a syringe pump or to 490 mL of dextrose 5% if syringe pump is not available.

Intravenous

Uncomplicated premature labour

Adult: To arrest labour between 22-37 wk of gestation: Initially, 5 mcg/min, w/ increments of 2.5 mcg/min at 20 min intervals until contractions stop. Max: 20 mcg/min. Continue for 1 hr after contractions have ceased, then decrease by 2.5 mcg/min every 20 min to lowest dose that maintains suppression. Max duration: 48 hr.

Reconstitution: Add 10 mL of Vacanyl soln for inj to 40 mL of dextrose 5% if using a syringe pump or to 490 mL of dextrose 5% if syringe pump is not available.

Inhalation

Severe bronchospasm

Adult: As 1% nebuliser soln: 2.5-10 mg 2-4 times daily.

Child: <25 kg: 2-5 mg 2-4 times daily; ≥25 kg: 5 mg 2-4 times daily.

How should I use Vacanyl?

Use Vacanyl as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Vacanyl is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Vacanyl at home, a health care provider will teach you how to use it. Be sure you understand how to use Vacanyl. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
• Do not use Vacanyl if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
• If you miss a dose of Vacanyl and are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Vacanyl.

Uses of Vacanyl in details

Use: Labeled Indications

Asthma/Bronchospasm: Prevention and reversal of bronchospasm in patients ≥12 years of age with asthma and reversible bronchospasm associated with bronchitis and emphysema

Off Label Uses

Extravasation management, sympathomimetic vasoconstrictors

Data from a limited number of patients suggests that Vacanyl may be beneficial for the management of extravasation of sympathomimetic vasoconstrictors.

Vacanyl description

Vacanyl turbuhaler is a breath-activated, multiple-dose powder inhaler free from propellant, lubricant, preservative, carrier substances or other additives.

Vacanyl injection also contains the following inactive ingredients: Sodium chloride, HCl (for pH adjustment) and water for injections.

Vacanyl sulphate is 2-(tert-butylamino)-1-(3,5-dihydroxyphenyl)ethanol sulphate.

Vacanyl dosage

Tablet: Adults: Usual Dose: 1-2 tablets. Children 12-15 years: 1 tablet. All doses to be taken 2-3 times daily.

To be administered at approximately 6-hr intervals. In most patients, the optimum single dose is 2 tablets. In patients unusually sensitive to sympathomimetic amines, initiate treatment with 1 tablet 3 times a day. If adequate bronchodilation is not obtained, the dose may be increased to 2 tablets.

Syrup: Adults and Children >15 years: 10-15 mL (2-3 tsp). Children 7-15 years: 5-10 mL (1-2 tsp); 3-7 years: 2.5-5 mL (½-1 tsp); <3 years: Not recommended. All doses to be taken 3 times a day.

Nebulizing Solution: Vacanyl nebulizing solution is used with dilution.

Inhale 1 mL of solution containing Vacanyl 2.5 mg every 6 hrs (or 4 times in 24-hr period).

If the entire dose is not inhaled at 1 occasion, the solution is stable for 24 hrs in the reservoir of the nebulizer.

Note: The patient's inhalation technique should be checked regularly and the optimal dose of Vacanyl should be adjusted for each nebulizer. If the effect of the inhalation is reduced, the patient should seek medical care.

Nonselective blocking agents may partly or totally inhibit the effect of β-stimulants.

Directions for Use: 1. Pipette 1 mL of Vacanyl nebulizing solution from the bottle by using a calibrated medicine dropper provided in the pack, equivalent to Vacanyl 2.5 mg.

2. Drop the solution into an electric nebulizer and dilute it with normal saline solution 2 mL and start inhalation.

3. Repeat the same procedure every 6 hrs or 4 times in 24-hr period.

Vacanyl interactions

See also:
What other drugs will affect Vacanyl?

Drug Interactions

The concomitant use of Vacanyl with other sympathomimetic agents is not recommended, since the combined effect on the cardiovascular system may be deleterious to the patient

Monoamine Oxidase Inhibitors or Tricyclic Antidepressants: Vacanyl should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, since the action of Vacanyl on the vascular system may be potentiated

Beta-Blockers Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-agonists, such as Vacanyl, but may produce severe bronchospasm in asthmatic patients. Therefore, patients with asthma should not normally be treated with beta-blockers. However, under certain circumstances, e.g., as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic blocking agents in patients with asthma. In this setting, cardioselective beta-blockers could be considered, although they should be administered with caution

Diuretics The ECG changes and/or hypokalemia that may result from the administration of nonpotassium-sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Although the clinical significance of these effects is not known, caution is advised in the coadministration of beta-agonists with nonpotassium-sparing diuretics.

Vacanyl side effects

See also:
What are the possible side effects of Vacanyl?

Applies to Vacanyl: oral elixir, oral tablet

Other dosage forms:

• subcutaneous solution

In addition to its needed effects, some unwanted effects may be caused by Vacanyl (the active ingredient contained in Vacanyl). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Vacanyl:

More common:

• Shakiness in the legs, arms, hands, or feet
• trembling or shaking of the hands or feet

Less common:

• Extra heartbeat
• feeling faint, dizzy, or lightheadedness
• feeling of warmth or heat
• flushing or redness of the skin, especially on the face and neck
• headache
• sweating

Rare

• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• excessive muscle tone
• muscle stiffness
• muscle tension or tightness

If any of the following symptoms of overdose occur while taking Vacanyl, get emergency help immediately:

Symptoms of overdose:

• Arm, back, or jaw pain
• blurred vision
• chest pain or discomfort
• chest tightness or heaviness
• confusion
• convulsions
• decreased urine
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dry mouth
• fainting
• fast, pounding, or irregular heartbeat or pulse
• general feeling of discomfort or illness
• increased thirst
• loss of appetite
• mood changes
• muscle pain or cramps
• nausea or vomiting
• nervousness
• numbness or tingling in the hands, feet, or lips
• pounding in the ears
• seizures
• shortness of breath
• sleeplessness
• slow or fast heartbeat
• trouble sleeping
• unable to sleep
• unusual tiredness or weakness

Minor Side Effects

Some of the side effects that can occur with Vacanyl may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

• Sleepiness or unusual drowsiness

Less common:

• Anxiety
• lack or loss of strength

Rare

• Fever
• rash
• redness, soreness, or itching skin
• seeing, hearing, or feeling things that are not there
• sores, welting, or blisters

Vacanyl contraindications

See also:
What is the most important information I should know about Vacanyl?

1.

Prolonged Tocolysis

Vacanyl has not been approved for and should not be used for prolonged tocolysis (beyond 48-72 hours). In particular, Vacanyl should not be used for maintenance tocolysis in the outpatient or home setting.

2.

Hypersensitivity

Vacanyl injection is contraindicated in patients known to be hypersensitive to sympathomimetic amines or any component of this drug product.

Active ingredient matches for Vacanyl:

Terbutaline in Thailand.

Terbutaline sulfate in Thailand.

List of Vacanyl substitutes (brand and generic names)	Sort by popularity
Unit description / dosage (Manufacturer)	Price, USD
Tolbin (Argentina, Malaysia, Thailand)
1 g x 10's (Medispan Limited.)	$ 0.58
600 mg x 10's (Medispan Limited.)	$ 0.39
800 mg x 10's (Medispan Limited.)	$ 0.48
Tolbin 2.5 mg x 1000's (Medispan Limited.)
Tolbin 2.5 mg x 100 x 10's (Medispan Limited.)
Tolbin 60 mL (Medispan Limited.)
Tolbin 1g TAB / 10 (Medispan Limited.)	$ 0.58
Tolbin 600mg TAB / 10 (Medispan Limited.)	$ 0.39
Tolbin 800mg TAB / 10 (Medispan Limited.)	$ 0.48
Tolbin 1000 mg Tablet (Medispan Limited.)	$ 0.06
Tolbin 800 mg Tablet (Medispan Limited.)	$ 0.05
Tolbin 600 mg Tablet (Medispan Limited.)	$ 0.04
TOLBIN 1000MG TABLET 1 strip / 10 tablets each (Medispan Limited.)	$ 0.60
TOLBIN 600MG TABLET 1 strip / 10 tablets each (Medispan Limited.)	$ 0.46
TOLBIN 800MG TABLET 1 strip / 10 tablets each (Medispan Limited.)	$ 0.55
Tolbin oral liqd 60 mL x 1's (Medispan Limited.)
TOLBIN tab 1 g x 10's (Medispan Limited.)	$ 0.58
TOLBIN tab 600 mg x 10's (Medispan Limited.)	$ 0.39
TOLBIN tab 800 mg x 10's (Medispan Limited.)	$ 0.48
Tolbin 1000mg Tablet (Medispan Limited.)	$ 0.06
Tolbin 600mg Tablet (Medispan Limited.)	$ 0.05
Tolbin 800mg Tablet (Medispan Limited.)	$ 0.05
Tolbin Syrup
Syrup; Oral; Terbutaline Sulfate
Torcuf-BR (India)
Torcuf-BR Terbutaline sulphate 1.25 mg, bromhexine hydrochloride 4 mg, guaiphenesin 50 mg, menthol 1mg. SYR / 100ml (Elkos)	$ 0.65
TORCUF-BR syr 100ml (Elkos)	$ 0.65
Tossex- AX
Tossex- AX Terbutaline Sulphate 1.25mg, Guiaphenesin 50mg, AmbroxolHCI 15mg/5mL LIQD / 100ml	$ 0.46
Tusoloc (Taiwan)
Tusoloc 25 mg
Tusq- X- LIQ
Tusq- X- LIQ Terbutaline Sulphate 1.25mg, Bromhexine HCI 4mg, Guiafenesin 50mg/5mL LIQD / 100ml	$ 0.53
Tusq-X-LIQ
Tusq-X-LIQ Terbutaline Sulphate 1.25mg, Bromhexine HCI 4mg, Guiafenesin 50mg/5mL LIQD / 100ml	$ 0.53
Ventiphylline T
Ventiphylline T 2.5+100 Tablet (Yash Pharma Laboratories Limited)	$ 0.01
VENTIPHYLLINE-T (India)
10's (Yash Pharma)	$ 0.09
Ventiphylline-T Terbutaline 2.5 mg, Theophylline 100 mg. TAB / 10 (Yash Pharma)	$ 0.09
VENTIPHYLLINE-T tab 10's (Yash Pharma)	$ 0.09
Ventiphylline-T Terbutaline 2.5 mg, Theophylline 100 mg. TAB / 10 (Yash Pharma)	$ 0.09
Vida-Butaline (Hong Kong)
Vinterlin (Vietnam)
Vinterlin 0.5 mg/1 mL x 5 tube x 1 mL
Waltuz-BR (India)
Waltuz-BR Terbutaline 1.25 mg, guaiphenesin 50 mg, ambroxol15 mg, menthol 1 mg/5 mL. SYR / 100ml (Wallace)	$ 0.54
WALTUZ-BR syr 100ml (Wallace)	$ 0.56
Xenocof-A (India)
Xenocof-A Terbutaline sulphate 1.25 mg, bromhexine hydrochloride 2 mg, guaiphenesin 50 mg, menthol0.5 mg/5 mL. SYR / 100ml (Orchid)	$ 0.53
XENOCOF-A syr 100ml (Orchid)	$ 0.53
Yarisma (Indonesia)
Yarisma 2.5 mg x 10 x 10's (Yarindo)	$ 8.68
See 522 substitutes for Vacanyl

References

1. DailyMed. "TERBUTALINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "terbutaline". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "terbutaline". http://www.drugbank.ca/drugs/DB00871 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Vacanyl are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Vacanyl. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

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Information checked by Dr. Sachin Kumar, MD Pharmacology