• Vistafrin indications
• Uses of Vistafrin in details
• Vistafrin description
• Vistafrin dosage
• Vistafrin interactions
• Vistafrin side effects
• Vistafrin contraindications

What is Vistafrin?

Vistafrin (Vistafrin) is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Vistafrin is used to treat nasal and sinus congestion, or congestion of the tubes that drain fluid from your inner ears, called the eustachian (yoo-STAY-shun) tubes.

Vistafrin may also be used for purposes not listed in this medication guide.

Vistafrin indications

Vistafrin is used for the temporary relief of stuffy nose, sinus, and ear symptoms caused by the common cold, flu, allergies, or other breathing illnesses (e.g., sinusitis, bronchitis). This medication works by decreasing swelling in the nose and ears, thereby lessening discomfort and making it easier to breathe.

Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.

How should I use Vistafrin?

Use Vistafrin drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Vistafrin drops is for use in the eye only. Avoid contact with the nose or mouth.
• To use Vistafrin drops, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eye for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including your eye. Keep the container tightly closed.
• Do not wear contact lenses while you are using Vistafrin drops. Sterilize contact lenses according to the manufacturer's directions and check with your doctor before using them.
• Do not use Vistafrin drops if it is brown or contains particles.
• If you miss a dose of Vistafrin drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Vistafrin drops.

Uses of Vistafrin in details

Use: Labeled Indications

Hypotension/shock: Treatment of hypotension, vascular failure in shock. Note: Not recommended for routine use in the treatment of septic shock; use should be limited until more evidence demonstrating positive clinical outcomes becomes available (Rhodes 2017).

Guideline recommendations:

Cardiogenic shock: The 2017 American Heart Association (AHA) scientific statement for the Contemporary Management of Cardiogenic Shock recommends Vistafrin, if needed, be considered for initial vasoactive management of cardiogenic shock due to aortic stenosis, mitral stenosis, or dynamic left ventricular outflow tract (LVOT) obstruction (AHA [van Diepen 2017]).

Hypotension during anesthesia: As a vasoconstrictor in regional analgesia

Nasal congestion: As a decongestant [OTC]

Off Label Uses

Hypotension in patients with obstructive hypertrophic cardiomyopathy

Vistafrin is a pure alpha1 agonist that will increase systemic vascular resistance without increasing heart rate or contractility. This is advantageous in patients with obstructive hypertrophic cardiomyopathy and hypotension since increases in both heart rate and contractility may cause the obstruction to worsen, leading to a decrease in cardiac output. Other vasopressors like dopamine, epinephrine, and norepinephrine may increase contractility and/or heart rate. Additional trials may be necessary to further define the role of Vistafrin in this condition.

Based on the American Urological Association guidelines for the management of priapism, due to the low risk of cardiovascular side effects intracavernous injection of Vistafrin is recommended for ischemic priapism that persists following aspiration/irrigation.

Vistafrin description

Vistafrin is a sympathomimetic amine that acts predominantly on α-adrenergic receptors. It is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs.

Vistafrin dosage

Vistafrin Dosage

Generic name: Vistafrin 10mg in 1mL

Dosage form: injection

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

General Dosage and Administration Instructions

Vistafrin (Vistafrin) Injection, 10 mg/mL must be diluted before administration as an intravenous bolus or continuous intravenous infusion to achieve the desired concentration:

• Bolus: Dilute with normal saline or 5% dextrose in water.
• Continuous infusion: Dilute with normal saline or 5% dextrose in water.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Do not use if the solution is colored or cloudy, or if it contains particulate matter. The diluted solution should not be held for more than 4 hours at room temperature or for more than 24 hours under refrigerated conditions. Discard any unused portion.

During Vistafrin administration:

• Correct intravascular volume depletion.
• Correct acidosis. Acidosis may reduce the effectiveness of Vistafrin.

Dosing for Treatment of Hypotension during Anesthesia

The following are the recommended dosages for the treatment of hypotension during anesthesia.

• The recommended initial dose is 40 to 100 mcg administered by intravenous bolus. May administer additional boluses every 1-2 minutes as needed; not to exceed a total dosage of 200 mcg.
• If blood pressure is below the target goal, start a continuous intravenous infusion with an infusion rate of 10 to 35 mcg/minute; not to exceed 200 mcg/minute.
• Adjust dosage according to the blood pressure goal.

Prepare a 100 mcg/mL Solution for Bolus

Intravenous Administration

For bolus intravenous administration, prepare a solution containing a final concentration of 100 mcg/mL of Vistafrin:

• Withdraw 10 mg (1 mL of 10 mg/mL) of Vistafrin and dilute with 99 mL of 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP.
• Withdraw an appropriate dose from the 100 mcg/mL solution prior to bolus intravenous administration.

Prepare a Solution for Continuous

Intravenous Administration

For continuous intravenous infusion, prepare a solution containing a final concentration of 20 mcg/mL of Vistafrin in 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP:

• Withdraw 10 mg (1 mL of 10 mg/mL) of Vistafrin and dilute with 500 mL of 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP.

Directions for Dispensing from Pharmacy Bulk Vial

The Pharmacy Bulk Vial is intended for dispensing of single doses to multiple patients in a pharmacy admixture program and is restricted to the preparation of admixtures for infusion. Each closure shall be penetrated only one time with a suitable sterile transfer device or dispensing set that allows measured dispensing of the contents. The Pharmacy Bulk Vial is to be used only in a suitable work area such as a laminar flow hood (or an equivalent clean air compounding area). Dispensing from a pharmacy bulk vial should be completed within 4 hours after the vial is penetrated.

More about Vistafrin (Vistafrin)

• Side Effects
• During Pregnancy or Breastfeeding
• Dosage Information
• Drug Interactions
• Support Group
• 0 Reviews - Add your own review/rating

Consumer resources

• Vistafrin
• Vistafrin (Advanced Reading)

• Other brands: Neo-Synephrine, Vistafrin Congestion, Sudogest PE, Vistafrin Children's Nasal Decongestant, More (9) »

Professional resources

• Vistafrin (FDA)
• Vistafrin (AHFS Monograph)

Related treatment guides

• Hypotension

Vistafrin interactions

See also:
What other drugs will affect Vistafrin?

Acetaminophen: May increase the serum concentration of Vistafrin (Systemic). Monitor therapy

Alpha1-Blockers: May diminish the vasoconstricting effect of Alpha1-Agonists. Similarly, Alpha1-Agonists may antagonize Alpha1-Blocker vasodilation. Monitor therapy

AtoMOXetine: May enhance the hypertensive effect of Sympathomimetics. AtoMOXetine may enhance the tachycardic effect of Sympathomimetics. Monitor therapy

Benzylpenicilloyl Polylysine: Alpha1-Agonists may diminish the diagnostic effect of Benzylpenicilloyl Polylysine. Management: Consider use of a histamine skin test as a positive control to assess a patient's ability to mount a wheal and flare response. Consider therapy modification

Cannabinoid-Containing Products: May enhance the tachycardic effect of Sympathomimetics. Exceptions: Cannabidiol. Monitor therapy

Chloroprocaine: May enhance the hypertensive effect of Vistafrin (Systemic). Monitor therapy

CloZAPine: May diminish the therapeutic effect of Vistafrin (Systemic). Monitor therapy

Cocaine (Topical): May enhance the hypertensive effect of Sympathomimetics. Management: Consider alternatives to use of this combination when possible. Monitor closely for substantially increased blood pressure or heart rate and for any evidence of myocardial ischemia with concurrent use. Consider therapy modification

Doxofylline: Sympathomimetics may enhance the adverse/toxic effect of Doxofylline. Monitor therapy

Ergot Derivatives: May enhance the hypertensive effect of Alpha1-Agonists. Ergot Derivatives may enhance the vasoconstricting effect of Alpha1-Agonists. Exceptions: Ergoloid Mesylates; Nicergoline. Avoid combination

FentaNYL: Alpha1-Agonists may decrease the serum concentration of FentaNYL. Specifically, fentanyl nasal spray serum concentrations may decrease and onset of effect may be delayed. Monitor therapy

Guanethidine: May enhance the arrhythmogenic effect of Sympathomimetics. Guanethidine may enhance the hypertensive effect of Sympathomimetics. Monitor therapy

Hyaluronidase: May enhance the vasoconstricting effect of Vistafrin (Systemic). Management: Avoid the use of hyaluronidase to enhance dispersion or absorption of Vistafrin. Use of hyaluronidase for other purposes in patients receiving Vistafrin may be considered as clinically indicated. Avoid combination

Iobenguane Radiopharmaceutical Products: Alpha1-Agonists may diminish the therapeutic effect of Iobenguane Radiopharmaceutical Products. Management: Discontinue all drugs that may inhibit or interfere with catecholamine transport or uptake for at least 5 biological half-lives before iobenguane administration. Do not administer these drugs until at least 7 days after each iobenguane dose. Avoid combination

Ioflupane I 123: Vistafrin (Systemic) may diminish the diagnostic effect of Ioflupane I 123. Monitor therapy

Linezolid: May enhance the hypertensive effect of Sympathomimetics. Management: Reduce initial doses of sympathomimetic agents, and closely monitor for enhanced pressor response, in patients receiving linezolid. Specific dose adjustment recommendations are not presently available. Consider therapy modification

Monoamine Oxidase Inhibitors: May enhance the hypertensive effect of Alpha1-Agonists. While linezolid is expected to interact via this mechanism, management recommendations differ from other monoamine oxidase inhibitors. Refer to linezolid specific monographs for details. Exceptions: Linezolid. Avoid combination

Ozanimod: May enhance the hypertensive effect of Sympathomimetics. Management: Concomitant use of ozanimod with sympathomimetic agents is not recommended. If combined, monitor patients closely for the development of hypertension, including hypertensive crises. Consider therapy modification

Propacetamol: May increase the serum concentration of Vistafrin (Systemic). Management: Monitor patients closely for increased side effects of Vistafrin if propacetamol is used concomitantly. Patients with underlying blood pressure issues or arrhythmias may need closer monitoring and may warrant consideration of alternative therapies. Monitor therapy

Solriamfetol: Sympathomimetics may enhance the hypertensive effect of Solriamfetol. Sympathomimetics may enhance the tachycardic effect of Solriamfetol. Monitor therapy

Sympathomimetics: May enhance the adverse/toxic effect of other Sympathomimetics. Monitor therapy

Tedizolid: May enhance the hypertensive effect of Sympathomimetics. Tedizolid may enhance the tachycardic effect of Sympathomimetics. Monitor therapy

Tricyclic Antidepressants: May enhance the therapeutic effect of Alpha1-Agonists. Tricyclic Antidepressants may diminish the therapeutic effect of Alpha1-Agonists. Monitor therapy

Vistafrin side effects

See also:
What are the possible side effects of Vistafrin?

Applies to Vistafrin: intravenous solution

As well as its needed effects, Vistafrin (the active ingredient contained in Vistafrin) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking Vistafrin, check with your doctor or nurse immediately:

Incidence not known:

• Blurred vision
• chest pain or discomfort
• difficult or labored breathing
• dizziness
• fainting
• fast, slow, or irregular heartbeat
• headache
• nausea or vomiting
• nervousness
• pain in the shoulders, arms, jaw, or neck
• pounding in the ears
• sweating
• tightness in the chest
• unusual tiredness

If any of the following symptoms of overdose occur while taking Vistafrin, get emergency help immediately:

Symptoms of overdose:

• Feeling of fullness in the head
• pounding or rapid pulse
• tingling in the arms or legs
• vomiting

Minor Side Effects

Some Vistafrin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:

• Heartburn
• itching skin
• nausea
• pain in the neck
• pain or discomfort in chest, upper stomach, or throat

Vistafrin contraindications

See also:
What is the most important information I should know about Vistafrin?

Minims Vistafrin should not be used in patients with severe hypertension, ventricular tachycardia, or in patients who are hypersensitive to it or to any of the components.

Active ingredient matches for Vistafrin:

Phenylephrine in Spain.

Phenylephrine hydrochloride in Spain.

List of Vistafrin substitutes (brand and generic names)	Sort by popularity
Unit description / dosage (Manufacturer)	Price, USD
Triaminic Thin Strips Nasal Congestion (Canada)
Triaminic Thin Strips Nasal Congestion strip 2.5 mg (Novartis consumer)
Triaminic toddler congestion (Canada)
Triaminic Toddler Congestion Thin Strips
Strip; Oral; Phenylephrine Hydrochloride 2.5 mg
Triaminic Toddler Congestion Thin Strips strip 2.5 mg (Novartis Consumer Health Canada Inc. (Canada))
Trigenic CS
Trigenic CS 60 ml Syrup (Trigenesis Lifesciences Pvt. Ltd.)	$ 0.03
Tromide Plus
Tromide Plus Eye 5 ml Drop (Entod Pharmaceuticals Ltd)	$ 0.11
Tromide Plus Eye 3 ml Drop (Entod Pharmaceuticals Ltd)	$ 0.16
TROMIDE PLUS 5%/0.8% EYE DROPS 1 packet / 5 ML eye drop each (Entod Pharmaceuticals Ltd)	$ 0.58
Tromide Plus 5% w/v/0.8% w/v Eye Drop (Entod Pharmaceuticals Ltd)	$ 0.58
Tropifrin
Tropifrin Eye 3 ml Drop (Jawa Pharmaceuticals (India) Pvt. Ltd.)	$ 0.11
TROPIFRIN 5%/0.8% EYE DROPS 1 packet / 3 ML eye drop each (Jawa Pharmaceuticals (India) Pvt. Ltd.)	$ 0.74
TROPIFRIN 5%W/V/0.8%W/V EYE DROPS 1 packet / 5 ML eye drop each (Jawa Pharmaceuticals (India) Pvt. Ltd.)	$ 0.82
Tropifrin 5% w/v/0.8% w/v Eye Drop (Jawa Pharmaceuticals (India) Pvt. Ltd.)	$ 0.74
Tropifrin 5% w/v/0.8 (Jawa Pharmaceuticals (India) Pvt. Ltd.)	$ 0.82
TRUSTYL-COLD (India)
60ml (AHPL)	$ 0.33
Trustyl-Cold Phenylephrine 2.5 mg, Paracetamol 125 mg, Chlorpheniramine maleate 1mg/5 mL. SYR / 60ml (AHPL)	$ 0.33
TRUSTYL-COLD syr 60ml (AHPL)	$ 0.36
Trustyl-Cold Phenylephrine 2.5 mg, Paracetamol 125 mg, Chlorpheniramine maleate 1mg/5 mL. SYR / 60ml (AHPL)	$ 0.33
Tur-Bi-Cal
Unicold-S (India)
Unicold-S Cetirizine 2.5 mg, paracetamol12.5 mg, phenylephrinehydrochloride 5 mg. O-SUSP / 60ml (Unikind)	$ 0.42
UNICOLD-S oral susp 60ml (Unikind)	$ 0.42
Uroflam Forte (Peru)
Vazculep
Vazculep injection 10 mg/mL (Eclat Pharmaceuticals, LLC (US))
Venmol Plus Tablet
Venmol Plus Tablet (Vencare Formulations Pvt Ltd)	$ 0.02
Ventirex C
Ventirex C 100 ml Syrup (Unimarck Pharma (India) Limited)	$ 0.03
Ventirex C 2.5 mg/30 mg Syrup (Unimarck Pharma (India) Limited)	$ 0.61
Vibrocil Microdosificador (Peru)
Vibrocilfen (Portugal)
Vinkold (India)
Vinkold Cetirizine dihydrochloride 5mg, paracetamol 500 mg, phenylephrine 10 mg TAB / 10 (Vinca)	$ 0.29
VINKOLD tab 10's (Vinca)	$ 0.29
Visadron (Austria, Bahrain, Belgium, Cyprus, Egypt, Germany, Iraq, Jordan, Kenya, Kuwait, Lebanon, Libya, Luxembourg, Netherlands, Portugal, Qatar, Saudi Arabia, Spain, Sudan, United Arab Emirates, Yemen)
Drops; Ophthalmic; Phenylephrine Hydrochloride (Alcon)
Visopt (Australia)
Vistosan (Germany)
Vital Eyes (United States)
Wei Li Ang (China)
Weiscalina (Mexico)
Zedex Cold (India)
Zedex Cold Paracetamol 125 mg, phenylephrine 5 mg, chlorpheniramine maleate 1 mg, sodium citrate 60 mg, menthol1 mg. SYR / 60ml (Wockhardt (Spectra))
ZEDEX COLD 125 MG/5ML/5 MG/5ML SYRUP 1 bottle / 60 ML syrup each (Wockhardt (Spectra))	$ 0.46
ZEDEX COLD syr 60ml (Wockhardt (Spectra))	$ 0.42
Zedex Cold 125mg/5ml/5mg/ml Syrup (Wockhardt (Spectra))	$ 0.46
Zednic
Zednic 60 ml Suspension (Zedchem Pharma)	$ 0.04
See 990 substitutes for Vistafrin

References

1. PubChem. "phenylephrine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
2. DrugBank. "phenylephrine". http://www.drugbank.ca/drugs/DB00388 (accessed September 17, 2018).
3. MeSH. "Cardiotonic Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Vistafrin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Vistafrin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

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Information checked by Dr. Sachin Kumar, MD Pharmacology