Antidiazox Uses

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What is Antidiazox?

Antidiazox belongs to a group of medicines called antiprotozoals. It is used to treat diarrhea that is caused by certain types of protozoa (tiny, one-celled animals).

Antidiazox is available only with your healthcare professional's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, Antidiazox is used in certain patients with the following medical condition:

Antidiazox indications

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Diarrhea Caused by Giardia Lamblia or Cryptosporidium Parvum

Antidiazox for

Oral Suspension (patients 1 year of age and older) and Antidiazox Tablets (patients 12 years and older) are indicated for the treatment of diarrhea caused by Giardia lamblia or Cryptosporidium parvum.

Limitations Of Use

Antidiazox for

Oral Suspension and Antidiazox Tablets have not been shown to be effective for the treatment of diarrhea caused by Cryptosporidium parvum in HIV-infected or immunodeficient patients.

How should I use Antidiazox?

Use Antidiazox suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Antidiazox suspension.

Uses of Antidiazox in details

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Use: Labeled Indications

Diarrhea, infectious: Treatment of diarrhea caused by Cryptosporidium parvum or Giardia lamblia

Off Label Uses

Clostridioides (formerly Clostridium) difficile infection

Current evidence from small, controlled trials regarding the use of Antidiazox in the management of C. difficile infection suggests that it may be comparable to the use of oral metronidazole or vancomycin. The Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology (SHEA) clinical practice guidelines for C. difficile infection state that Antidiazox is considered a probable effective alternative for primary C. difficile infection in adults without specific recommendations for use. Larger controlled trials are needed.

Cryptosporidiosis-associated diarrhea in HIV-infected patients

Based on the US Department of Health and Human Services (HHS) Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, Antidiazox may be considered as an alternative agent in the management of diarrhea caused by Cryptosporidium in HIV-infected patients (must be used in combination with optimized antiretroviral therapy (ART), electrolyte replacement, and symptomatic treatment and rehydration).

Antidiazox description

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Antidiazox, also known by the brand name Antidiazox, is a synthetic nitrothiazolyl-salicylamide derivative and an anti-protozoal agent. It is approved for treatment of infectious diarrhea caused by Cryptosporidium parvum and Giardia lamblia in patients 1 year of age and older. Following oral administration it is rapidly hydrolyzed to its active metabolite, tizoxanide, which is 99% protein bound. Peak concentrations are observed 1–4 hours after administration. It is excreted in the urine, bile and feces. Untoward effects include abdominal pain, vomiting and diarrhea. [Wikipedia]

Antidiazox dosage

Antidiazox Dosage

Generic name: Antidiazox 500mg

Dosage form: tablet; powder, for oral suspension

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

2.1 Recommended Dosage and Important Administration Instructions

Important Administration Instructions for Pediatric Patients 11 years of Age or Younger:

Antidiazox tablets should not be administered to pediatric patients 11 years of age or younger because a single tablet contains a greater amount of Antidiazox than the recommended dosing in this pediatric age group.

Table 1. Recommended Dosage

Age Dosage Duration
1-3 years

5 mL of Antidiazox for

Oral suspension

(100 mg Antidiazox) taken orally every 12 hours with food

4-11 years

10 mL of Antidiazox for

Oral Suspension

(200 mg Antidiazox) taken orally every 12 hours with food

3 Days
12 years and older One Antidiazox Tablet (500 mg Antidiazox) taken orally every 12 hours with food or 25 mL of Antidiazox for

Oral Suspension (500 mg Antidiazox) taken orally every 12 hours with food

2.2 Directions for Mixing Antidiazox for

Oral Suspension

Reconstitute Antidiazox for

Oral Suspension as follows:

Keep container tightly closed, and shake the suspension well before each administration. The reconstituted suspension may be stored for 7 days at room temperature, after which any unused portion must be discarded.

More about Antidiazox (Antidiazox)

Consumer resources

Professional resources

Related treatment guides

Antidiazox interactions

See also:
What other drugs will affect Antidiazox?

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Tizoxanide is highly bound to plasma protein (>99.9%). Therefore, caution should be used when administering Antidiazox concurrently with other highly plasma protein-bound drugs with narrow therapeutic indices, as competition for binding sites may occur (e.g., warfarin). In vitro metabolism studies have demonstrated that tizoxanide has no significant inhibitory effect on cytochrome P450 enzymes. Although no drug-drug interaction studies have been conducted in vivo, it is expected that no significant interaction would occur when Antidiazox is co-administered with drugs that either are metabolized by or inhibit cytochrome P450 enzymes.

Antidiazox side effects

See also:
What are the possible side effects of Antidiazox?

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

The safety of Antidiazox was evaluated in 2177 HIV-uninfected subjects 12 months of age and older who received Antidiazox Tablets or Antidiazox for

Oral Suspension at the recommended dose for at least three days. In pooled controlled clinical trials involving 536 HIV-uninfected subjects treated with Antidiazox Tablets or Antidiazox for

Oral Suspension, the most common adverse reactions were abdominal pain, headache, chromaturia and nausea ( > 2%).

Safety data were analyzed separately for 280 HIV-uninfected subjects ≥ 12 years of age receiving Antidiazox at the recommended dose for at least three days in 5 placebo-controlled clinical trials and for 256 HIV-uninfected subjects 1 through 11 years of age in 7 controlled clinical trials. There were no differences between the adverse reactions reported for Antidiazox-treated subjects based upon age.

Postmarketing Experience

The following adverse reactions have been identified during post approval use of Antidiazox. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The following is a list of adverse reactions spontaneously reported with Antidiazox Tablets which were not included in clinical trial listings:

Gastrointestinal disorders: diarrhea, gastroesophageal reflux disease

Nervous System disorders: dizziness

Respiratory, thoracic and mediastinal disorders: dyspnea

Skin and subcutaneous tissue disorders: rash, urticaria

Antidiazox contraindications

See also:
What is the most important information I should know about Antidiazox?

Hypersensitivity

Antidiazox Tablets and Antidiazox for

Oral Suspension are contraindicated in patients with a prior hypersensitivity to Antidiazox or any other ingredient in the formulations.

Active ingredient matches for Antidiazox:

Nitazoxanide in Egypt.


List of Antidiazox substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Bestoflox N 30 ml Suspension (Bestochem Formulations (India) Ltd.)$ 0.07
Bestoflox N 200+500 Tablet (Bestochem Formulations (India) Ltd.)$ 0.10
Bestoflox N 100 mg/50 mg Suspension (Bestochem Formulations (India) Ltd.)$ 0.66
Bestoflox N 500 mg/200 mg Tablet (Bestochem Formulations (India) Ltd.)$ 0.14
Bionit 5 mg Tablet (Biochemix Healthcare Pvt Ltd)$ 0.07
Suspension; Oral; Nitazoxanide 100 mg / 5 ml (Siegfried)
Tablet, Dispersible; Oral; Nitazoxanide 200 mg (Siegfried)
Tablet; Oral; Nitazoxanide 500 mg (Siegfried)
Diarid Nitazoxanide 500 mg, Ofloxacin200 mg TAB / 10x10 (Veliko)$ 12.04
DIARID tab 10's (Veliko)$ 1.20
Suspension; Oral; Nitazoxanide 100 mg / 5 ml (Unipharm)
Tablet, Dispersible; Oral; Nitazoxanide 200 mg (Unipharm)
Tablet; Oral; Nitazoxanide 500 mg (Unipharm)
N-TEE dry syr 100 mg x 5 mL x 30ml (Olcare)$ 0.43

References

  1. DailyMed. "NITAZOXANIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "NITAZOXANIDE". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "NITAZOXANIDE". http://www.drugbank.ca/drugs/DB00507 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Antidiazox are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Antidiazox. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


1 consumer reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Antidiazox drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Expensive1
100.0%


Consumer reported time for results

No survey data has been collected yet


3 consumers reported age

Users%
< 12
66.7%
1-51
33.3%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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