What is Hydretic?
Hydretic is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Hydretic is also used to treat fluid retention (edema) that is caused by congestive heart failure, severe liver disease (cirrhosis), kidney disease, or treatment with a steroid or hormone medicine.
Hydretic is a thiazide diuretic (water pill). It is used to help reduce the amount of water in the body by increasing the flow of urine. It may also be used for other conditions as determined by your doctor.
Hydretic is available only with your doctor's prescription.
Hydretic indications
Hydretic Capsules are indicated in the management of hypertension either as the sole therapeutic agent, or in combination with other antihypertensives. Unlike potassium sparing combination diuretic products, Hydretic Capsules may be used in those patients in whom the development of hyperkalemia cannot be risked, including patients taking ACE inhibitors.
Usage in Pregnancy: The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.
Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Diuretics are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy. Dependent edema in pregnancy resulting from restriction of venous return by the expanded uterus is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary. There is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the mother (in the absence of cardiovascular disease), but which is associated with edema, including generalized edema in the majority of pregnant women. If this edema produces discomfort, increased recumbency will often provide relief. In rare instances this edema may cause extreme discomfort which is not relieved by rest. In these cases a short course of diuretics may provide relief and may be appropriate.
How should I use Hydretic?
Use Hydretic capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Hydretic capsules by mouth with or without food.
- If you take colestipol or cholestyramine for high cholesterol, ask your doctor or pharmacist how to take it with Hydretic capsules.
- Hydretic capsules may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
- If you miss a dose of Hydretic capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Hydretic capsules.
Uses of Hydretic in details
This medication is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Hydretic is a "water pill" (diuretic) that causes you to make more urine. This helps your body get rid of extra salt and water.
This medication also reduces extra fluid in the body (edema) caused by conditions such as heart failure, liver disease, or kidney disease. This can lessen symptoms such as shortness of breath or swelling in your ankles or feet.
How to use Hydretic
Take this medication by mouth as directed by your doctor, usually once daily in the morning with or without food. It is best to avoid taking this medication within 4 hours of your bedtime to prevent having to get up to urinate.
The dosage is based on your medical condition and response to treatment.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.
Cholestyramine and colestipol can decrease the absorption of Hydretic. If you are taking either of these drugs, take them at least 4 hours before or after taking Hydretic.
Tell your doctor if your condition does not improve or if it worsens (for example, your blood pressure readings increase).
Hydretic description
Each film-coated tablet contains losartan potassium 50 mg and Hydretic 12.5 mg.
Losartan potassium is 2-Butyl-4-chloro-1-[p-o-1H-tetrazol-5-yl-phenyl)benzyl]imidazole-5-methanol, potassium. Its empirical formula is C22H22ClKN6O and molecular weight is 461.
Hydretic is 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H8ClN3O4S2 and molecular weight is 297.7.
Hydretic dosage
Hydretic Dosage
Generic name: Hydretic 12.5mg
Dosage form: capsule, gelatin coated
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
For Control of Hypertension: The adult initial dose of Hydretic is one capsule given once daily whether given alone or in combination with other antihypertensives. Total daily doses greater than 50 mg are not recommended.
More about Hydretic (Hydretic)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
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- Drug Interactions
- Support Group
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- En Espanol
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- Generic Availability
Consumer resources
- Hydretic
- Hydretic (Advanced Reading)
- Other brands: Aquazide H
Professional resources
- Hydretic (AHFS Monograph)
- Hydretic (FDA)
Related treatment guides
- Diabetes Insipidus
- Edema
- High Blood Pressure
- Nephrocalcinosis
- Osteoporosis
Hydretic interactions
See also:
What other drugs will affect Hydretic?
DIAMOX®. modifies phenytoin metabolism with increased serum levels of phenytoin. This may increase or enhance the occurrence of osteomalacia in some patients receiving chronic phenytoin therapy. Caution is advised in patients receiving chronic concomitant therapy.
By decreasing the gastrointestinal absorption of primidone, DIAMOX may decrease serum concentrations of primidone and its metabolites, with a consequent possible decrease in anticonvulsant effect. Caution is advised when beginning, discontinuing, or changing the dose of DIAMOX in patients receiving primidone.
Because of possible additive effects with other carbonic anhydrase inhibitors, concomitant use is not advisable.
Hydretic may increase the effects of other folic acid antagonists.
Hydretic may increase or decrease blood glucose levels. Consideration should be taken in patients being treated with antidiabetic agents.
Hydretic decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect.
Hydretic reduces urinary excretion of quinidine and may enhance its effect.
Hydretic may prevent the urinary antiseptic effect of methenamine.
Hydretic increases lithium excretion and the lithium may be decreased.
Hydretic and sodium bicarbonate used concurrently increases the risk of renal calculus formation.
Hydretic may elevate cyclosporine levels.
Hydretic side effects
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What are the possible side effects of Hydretic?
The adverse reactions associated with Hydretic have been shown to be dose related. In controlled clinical trials, the adverse events reported with doses of 12.5 mg Hydretic once daily were comparable to placebo. The following adverse reactions have been reported for doses of Hydretic 25 mg and greater and, within each category, are listed in the order of decreasing severity.
Body as a whole: Weakness.
Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs).
Digestive: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia.
Hematologic: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia.
Hypersensitivity: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura.
Metabolic: Electrolyte imbalance, hyperglycemia, glycosuria, hyperuricemia.
Musculoskeletal: Muscle Spasm.
Nervous System/Psychiatric: Vertigo, paresthesia, dizziness, headache, restlessness.
Renal: Renal failure, renal dysfunction, interstitial nephritis.
Skin: Erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, alopecia.
Special Senses: Transient blurred vision, xanthopsia.
Urogenital: Impotence.
Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.
Hydretic contraindications
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What is the most important information I should know about Hydretic?
You should not use this medication if you are allergic to Hydretic or if you are unable to urinate.
Before using this medication, tell your doctor if you have liver disease, kidney disease, glaucoma, asthma or allergies, gout, diabetes, or if you are allergic to sulfa drugs or penicillin.
Avoid drinking alcohol, which can increase some of the side effects of Hydretic.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
There are many other drugs that can interact with Hydretic. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.
Active ingredient matches for Hydretic:
Hydrochlorothiazide in Egypt.
List of Hydretic substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Hyclosid | |
| Hydrex Semi (Finland) | |
| HYDRIDE (India) | |
| HYDRIDE Capsule/ Tablet / 25mg / 10 units (Micro Labs Ltd) | $ 0.22 |
| HYDRIDE Capsule/ Tablet / 12.5mg / 10 units (Micro Labs Ltd) | $ 0.13 |
| Hydride 12.5mg TAB / 10 (Micro Labs Ltd) | $ 0.12 |
| Hydride 25mg TAB / 10 (Micro Labs Ltd) | $ 0.20 |
| 12.5 mg x 10's (Micro Labs Ltd) | $ 0.12 |
| 25 mg x 10's (Micro Labs Ltd) | $ 0.20 |
| Hydride 25 mg Tablet (Micro Labs Ltd) | $ 0.02 |
| Hydride 12.5 mg Tablet (Micro Labs Ltd) | $ 0.02 |
| HYDRIDE 12.5 MG TABLET 1 strip / 10 tablets each (Micro Labs Ltd) | $ 0.14 |
| HYDRIDE 25 MG TABLET 1 strip / 10 tablets each (Micro Labs Ltd) | $ 0.23 |
| HYDRIDE tab 12.5 mg x 10's (Micro Labs Ltd) | $ 0.12 |
| HYDRIDE tab 25 mg x 10's (Micro Labs Ltd) | $ 0.20 |
| Hydride 12.5mg TAB / 10 (Micro Labs Ltd) | $ 0.12 |
| Hydride 25mg TAB / 10 (Micro Labs Ltd) | $ 0.20 |
| Hydride 12.5mg Tablet (Micro Labs Ltd) | $ 0.01 |
| Hydril | |
| Hydro Par | |
| Hydro-Aquil | |
| Hydro-Chlor (United States) | |
| Hydro-D | |
| Tablet; Oral; Hydrochlorothiazide 25 mg | |
| Tablet; Oral; Hydrochlorothiazide 50 mg | |
| Tablets; Oral; Hydrochlorothiazide 25 mg | |
| Tablets; Oral; Hydrochlorothiazide 50 mg | |
| Hydro-Diuril | |
| Hydro-Par (United States) | |
| Hydro-Saluric | |
| Hydro-T | |
| Hydro-Z (United States) | |
| Hydrochloorthiazid Orion (Netherlands) | |
| Hydrochloorthiazide (Netherlands) | |
| Tablet; Oral; Hydrochlorothiazide 25 mg | |
| Tablet; Oral; Hydrochlorothiazide 50 mg | |
| Tablets; Oral; Hydrochlorothiazide 25 mg | |
| Tablets; Oral; Hydrochlorothiazide 50 mg | |
| Hydrochloorthiazide A (Netherlands) | |
| Hydrochloorthiazide Actavis (Netherlands) | |
| Hydrochloorthiazide Apotex (Netherlands) | |
| Hydrochloorthiazide Aurobindo (Netherlands) | |
| Hydrochloorthiazide CF (Netherlands) | |
| Hydrochloorthiazide GenRx (Netherlands) | |
| Hydrochloorthiazide Katwijk (Netherlands) | |
See 1222 substitutes for Hydretic | |
References
- DailyMed. "AMLODIPINE BESYLATE; HYDROCHLOROTHIAZIDE; OLMESARTAN MEDOXOMIL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "hydrochlorothiazide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "hydrochlorothiazide". http://www.drugbank.ca/drugs/DB00999 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Hydretic are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Hydretic. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
