What is Lester?
Lester (Lester) belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins." Lester reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).
Lester is used to treat high cholesterol in adults. Lowering your cholesterol may help prevent heart disease and hardening of the arteries, conditions that can lead to heart attack, stroke, and vascular disease.
Lester may also be used for purposes not listed in this medication guide.
Lester indications
Drug therapy should be one component of multiple-risk-factor intervention in individuals who require modifications of their lipid profile. Lipid-altering agents should be used in addition to a diet restricted in saturated fat and cholesterol only when the response to diet and other nonpharmacological measures has been inadequate.
Primary Hyperlipidemia and Mixed Dyslipidemia
Lester tablets is indicated as an adjunctive therapy to diet to reduce elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), triglycerides (TG), and to increase HDL-C in adult patients with primary hyperlipidemia or mixed dyslipidemia.
Limitations of Use
Doses of Lester tablets greater than 4 mg once daily were associated with an increased risk for severe myopathy in premarketing clinical studies. Do not exceed 4 mg once daily dosing of Lester tablets.
The effect of Lester tablets on cardiovascular morbidity and mortality has not been determined.
Lester tablets has not been studied in Fredrickson Type I, III, and V dyslipidemias.
How should I use Lester?
Use Lester as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Lester by mouth with or without food.
- Taking Lester at the same time each day will help you remember to take it.
- Continue to take Lester even if you feel well. Do not miss any doses.
- If you miss a dose of Lester, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Lester.
Uses of Lester in details
Use: Labeled Indications
Primary hyperlipidemia and mixed dyslipidemia: As an adjunctive therapy to diet to reduce elevated total cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C) in adults with primary hyperlipidemia or mixed dyslipidemia.
Heterozygous familial hypercholesterolemia: As an adjunctive therapy to diet to reduce elevated total cholesterol, LDL-C, and apo B in children and adolescents ≥8 years of age.
Off Label Uses
Cardiac risk reduction for noncardiac surgery (perioperative therapy)
Based on the 2014 American College of Cardiology/American Heart Association (ACC/AHA) guidelines on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery, perioperative initiation of statins is reasonable for patients undergoing vascular surgery and may be considered in patients with clinical indications according to guideline-directed medical therapy who are undergoing elevated risk procedures. In patients undergoing non-cardiac surgery who are currently receiving a statin, the statin should be continued.
Noncardioembolic stroke/Transient ischemic attack (secondary prevention)
Based on the American Heart Association/American Stroke Association (AHA/ASA) guidelines for the prevention of stroke in patients with stroke and transient ischemic attack, statin therapy with intensive lipid-lowering effects is recommended to reduce the risk of recurrent stroke and future cardiovascular events in patients with ischemic stroke or TIA presumed to be of atherosclerotic origin who have an LDL-C concentration ≥100 mg/dL (with or without evidence for other clinical atherosclerotic cardiovascular disease [ASCVD]) or who have an LDL-C concentration <100 mg/dL (without evidence for other clinical ASCVD).
Primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD)
Based on the American College of Cardiology/American Heart Association (ACC/AHA) Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults and the National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia, Lester given for primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD) is effective and recommended in the management of this condition. Based on the US Preventive Services Task Force (USPSTF) recommendation statement on Statin Use for the Primary Prevention of Cardiovascular Disease (CVD) in Adults, initiation of low to moderate dose statin therapy is recommended in adults 40 to 75 years without a history of CVD who have ≥1 CVD risk factors (dyslipidemia, diabetes, hypertension, or smoking) and a calculated 10-year CVD event risk of ≥10%. Based on the American Heart Association (AHA) scientific statement for the secondary prevention after coronary artery bypass graft surgery, statin therapy (unless contraindicated) is recommended for all coronary artery bypass graft (CABG) surgery patients to help maintain long-term graft patency and help obtain the highest level of physical health and quality of life.
Lester description
Lester tablet contains the following excipients: Lactose, hydroxypropylcellulose, hydroxypropylmethylcellulose, magnesium aluminometasilicate, magnesium stearate, triethyl citrate, hydrated silicon dioxide, titanium oxide, carnauba wax.
Lester calcium is (+)-monocalcium bis(3R,5S,6E)-7-[2-cyclopropyl- 4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoate. It has a molecular formula of C50H46CaF2N2O8 and a molecular weight of 880.98.
It occurs as a white to pale yellowish white powder and is odorless. It is freely soluble in pyridine or in tetrahydrofuran, soluble in ethylene glycol, slightly soluble in methanol, very slightly soluble in ethanol (99.5) or in water, practically insoluble in acetonitrile or in diethyl ether. It dissolves in dilute hydrochloric acid.
Lester dosage
Lester Dosage
Generic name: Lester calcium 1.045mg
Dosage form: tablet, film coated
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
General Dosing Information
The dose range for Lester is 1 to 4 mg orally once daily at any time of the day with or without food. The recommended starting dose is 2 mg and the maximum dose is 4 mg. The starting dose and maintenance doses of Lester should be individualized according to patient characteristics, such as goal of therapy and response.
After initiation or upon titration of Lester, lipid levels should be analyzed after 4 weeks and the dosage adjusted accordingly.
Dosage in Patients with Renal Impairment
Patients with moderate and severe renal impairment (glomerular filtration rate 30 – 59 mL/min/1.73 m2 and 15 – 29 mL/min/1.73 m2 not receiving hemodialysis, respectively) as well as end-stage renal disease receiving hemodialysis should receive a starting dose of Lester 1 mg once daily and a maximum dose of Lester 2 mg once daily.
Use with Erythromycin
In patients taking erythromycin, a dose of Lester 1 mg once daily should not be exceeded.
Use with Rifampin
In patients taking rifampin, a dose of Lester 2 mg once daily should not be exceeded.
More about Lester (Lester)
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Consumer resources
- Lester
- Lester (Advanced Reading)
Professional resources
- Lester (AHFS Monograph)
- Lester (FDA)
Related treatment guides
- High Cholesterol
Lester interactions
See also:
What other drugs will affect Lester?
Cyclosporine
Cyclosporine significantly increased Lester exposure. Co-administration of cyclosporine with Lester is contraindicated.
Erythromycin
Erythromycin significantly increased Lester exposure. In patients taking erythromycin, a dose of Lester 1 mg once daily should not be exceeded.
Rifampin
Rifampin significantly increased Lester exposure. In patients taking rifampin, a dose of Lester 2 mg once daily should not be exceeded.
Gemfibrozil
Due to an increased risk of myopathy/rhabdomyolysis when HMG-CoA reductase inhibitors are coadministered with gemfibrozil, concomitant administration of Lester with gemfibrozil should be avoided.
Other Fibrates
Because it is known that the risk of myopathy during treatment with HMG-CoA reductase inhibitors is increased with concurrent administration of other fibrates, Lester should be administered with caution when used concomitantly with other fibrates.
Niacin
The risk of skeletal muscle effects may be enhanced when Lester is used in combination with niacin; a reduction in Lester dosage should be considered in this setting.
Colchicine
Cases of myopathy, including rhabdomyolysis, have been reported with HMG-CoA reductase inhibitors coadministered with colchicine, and caution should be exercised when prescribing Lester with colchicine.
Warfarin
Lester had no significant pharmacokinetic interaction with R-and S-warfarin. Lester had no significant effect on prothrombin time (PT) and international normalized ratio (INR) when administered to patients receiving chronic warfarin treatment. However, patients receiving warfarin should have their PT and INR monitored when Lester is added to their therapy.
Lester side effects
See also:
What are the possible side effects of Lester?
Applies to Lester: oral tablet
As well as its needed effects, Lester (the active ingredient contained in Lester) may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking Lester, check with your doctor immediately:
Less common:
- Difficulty with moving
- joint pain
- muscle aching or cramping
- muscle pains or stiffness
- pain in the arms and legs
- swollen joints
- Chills
- cough
- diarrhea
- fever
- general feeling of discomfort or illness
- headache
- loss of appetite
- nausea
- runny nose
- shivering
- sore throat
- sweating
- trouble sleeping
- unusual tiredness or weakness
- vomiting
Minor Side Effects
Some Lester side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:
Less common:
- Back pain
- difficulty having a bowel movement (stool)
- Hives or welts, itching skin, or rash
- redness of the skin
Lester contraindications
See also:
What is the most important information I should know about Lester?
You should not take Lester if you are allergic to it, if you are pregnant or breast-feeding, or if you have liver disease or severe kidney disease. You should not take Lester if you are also taking cyclosporine (Gengraf, Neoral, Sandimmune) or lopinavir and ritonavir (Kaletra).
Stop taking this medication and tell your doctor right away if you become pregnant.
Before taking Lester, tell your doctor if you have a thyroid disorder, if you have ever had liver or kidney disease, or if you drink more than 2 alcoholic beverages daily.
In rare cases, Lester can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Avoid eating foods that are high in fat or cholesterol. Lester will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.
Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.
Lester is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.
Active ingredient matches for Lester:
Pitavastatin in Brazil.
| Unit description / dosage (Manufacturer) | Price, USD |
| LESTER 100MG TABLET 1 strip / 10 tablets each (Mcastro Pharma) | $ 0.25 |
List of Lester substitutes (brand and generic names): | |
| LEKACE | |
| LEKACE 100MG TABLET 1 strip / 10 tablets each (J B Chemicals and Pharmaceuticals Ltd) | $ 0.40 |
| Letgo (India) | |
| Letgo 100mg TAB / 10 (Orion) | $ 0.28 |
| Letgo 200mg SR-TAB / 10 (Orion) | $ 0.54 |
| 100 mg x 10's (Orion) | $ 0.28 |
| 200 mg x 10's (Orion) | $ 0.54 |
| Letgo 1 Bottle 100 Tablet (Orion) | |
| LETGO tab 100 mg x 10's (Orion) | $ 0.28 |
| LETGO SR tab 200 mg x 10's (Orion) | $ 0.54 |
| Linac-SR | |
| Linac-SR 200mg TAB / 10 | |
| LINI S | |
| LINI S TABLET 1 strip / 10 tablets each (Orange Healthcare Pvt Ltd) | $ 0.70 |
| Litonac-SR (India) | |
| LITONAC-SR modified-release tab 200 mg x 10's (Little Greave) | $ 0.60 |
| Livalo (China, Japan, South Korea, Thailand, United States) | |
| Livalo 2 mg x 28's (Kowa) | |
| Livalo 2 mg x 140's (Kowa) | |
| Livalo 1 mg x 1's (Kowa) | |
| Livalo 2 mg x 1's (Kowa) | |
| Livalo FC tab 2 mg 1's (Kowa) | |
| Livalo tablet, film coated 1 mg/1 (Kowa) | |
| Livalo tablet, film coated 2.09 mg/1 (Kowa) | |
| Livalo tablet, film coated 2 mg/1 (Kowa) | |
| Livalo tablet, film coated 4.18 mg/1 (Kowa) | |
| Livalo tablet, film coated 4 mg/1 (Kowa) | |
| Livalo tablet, film coated 1.045 mg/1 (Kowa) | |
| Livalo OD (Japan) | |
| LIVASTAT | |
| Livazo (Germany, Poland, Spain) | |
| Livazo 1mg (Switzerland) | |
| Livazo 2mg (Switzerland) | |
| Livazo 4mg (Switzerland) | |
| Locet (India) | |
| Locet 200mg SR-TAB / 100 (Arvincare) | $ 5.30 |
| 200 mg x 100's (Arvincare) | $ 5.30 |
| LOCET 5MG SYRUP 1 bottle / 30 ML syrup each (Arvincare) | $ 0.22 |
| LOCET 5MG TABLET 1 strip / 10 tablets each (Arvincare) | $ 0.10 |
| LOCET SR tab 200 mg x 10's (Arvincare) | $ 0.53 |
| Locet 5mg Syrup (Arvincare) | $ 0.22 |
| Locet 5mg Tablet (Arvincare) | $ 0.01 |
| Locoace | |
| Locoace 100mg TAB / 10 | |
| LOCOACE 100MG TABLET 1 strip / 10 tablets each (Alchemist Life Science Ltd) | $ 0.17 |
| Locoace 100mg Tablet (Alchemist Life Science Ltd) | $ 0.02 |
| Locomin (Switzerland) | |
| Lofens (Bangladesh) | |
| Loflam (Oman) | |
| Loflam 15 mg x 30's | |
| Loflam 15 mg x 100's | |
See 2176 substitutes for Lester | |
References
- DailyMed. "PITAVASTATIN CALCIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "Aceclofenac". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "Pitavastatin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Lester are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lester. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
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Information checked by Dr. Sachin Kumar, MD Pharmacology
