What is Lugol?
There are many brands and forms of povidone Lugol topical available. Not all brands are listed on this leaflet.
Lugol is used on the skin to treat or prevent skin infection in minor cuts, scrapes, or burns. Lugol is also used in a medical setting to help prevent infection and promote healing in skin wounds, pressure sores, or surgical incisions.
Some forms of povidone Lugol topical are used inside the mouth to provide temporary relief of minor mouth pain or irritation, sore throat, or canker sore pain.
Lugol may also be used for purposes not listed in this medication guide.
Lugol indications
Intramuscular
Lugol deficiency disorders
Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Lugol): Up to 45 yr: 380 mg Lugol, as single IM doses to provide adequate protection from Lugol deficiency for up to 3 yr. Pregnant patient: Moderate to severe: 480 mg Lugol each yr.
Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Lugol): 380 mg Lugol, as single IM doses to provide adequate protection from Lugol deficiency for up to 3 yr. Infants up to 1 yr: 190 mg Lugol, as iodised oil (480 mg/ml Lugol).
Oral
Grave's disease
Child: Neonates: 1 drop of strong Lugol solution every 8 hr.
Oral
Radiation protection against radioactive Lugol
Adult: As Lugol: 100-150 mg 24 hr before procedure and daily for up to 10 days after procedure.
Child: As Lugol: Infants from birth to 1 mth with a predicted thyroid exposure of ≥5 centigrays (cGy): 16 mg. >1 mth to 3 yr with a predicted thyroid exposure of ≥5 cGy: 32 mg. >3 yr to 18 yr (except adolescents approaching adult size) with a predicted thyroid exposure of ≥5 cGy: 65 mg. Do not exceed once-daily doses.
Oral
Preoperative reduction of vascularity of the thyroid gland
Adult: As Lugol: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery.
Child: As Lugol: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery. As strong Lugol solution: 0.1-0.3 ml (or approx 3-5 drops) tid.
Oral
Cutaneous or lymphocutaneous sporotrichosis
Adult: As Lugol solution containing 1 g/mL: Initially, 1 mL tid, should continue for at least 1 mth after disappearance or stabilisation of the lesions.
Child: As Lugol: Initially, 250 mg (approx 5 drops of a solution containing 1 g/ml) tid. Max: 1.25-2 g (approx 25-40 drops) tid. Duration: 3-6 mth.
Oral
Thyroid storm
Adult: As Lugol: Up to 500 mg every 4 hr.
Oral
Lugol deficiency disorders
Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Lugol): 400 mg Lugol once yrly. Pregnant patient: 200 mg Lugol as a single dose. Moderate to severe: 300-480 mg Lugol each yr or 100-300 mg Lugol every 6 mth and for at least 1 yr postpartum.
Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Lugol): Infants up to 1 yr: Single dose of 100 mg Lugol; 1-5 yr: 200 mg Lugol; >6 yr: 400 mg Lugol.
Topical/Cutaneous
Cleaning wet ulcers and wounds
Adult: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.
Child: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.
Topical/Cutaneous
Minor, superficial skin wounds
Adult: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.
Child: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.
How should I use Lugol?
Use exactly as directed on the label, or as prescribed by your doctor.
Lugol is available in many different forms, such as a liquid, ointment, aerosol powder, cream, spray, swab, and soap. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Always follow directions on the medicine label about using this medicine on a child. Some forms of povidone Lugol topical should not be used in children of certain ages.
Lugol is usually applied to the skin as needed. First clean the area to be treated.
Shake Lugol spray well just before each use.
Allow the medicine to dry completely on the skin before applying a bandage. Do not apply a tight bandage.
Do not use this medicine on deep wounds, puncture wounds, animal bites, or serious burns. Do not apply over large skin areas.
When treating an infection, you may be given antibiotic medication to take by mouth. Use all medicines for the full prescribed length of time, even if your symptoms quickly improve.
Lugol used in the mouth may be used up to 4 times per day. How often you can use this medicine depends on what form you use. Follow all directions on the medicine label.
Do not use Lugol in the mouth if you are using a form that is made for use only on the skin.
To use Lugol spray in the mouth, spray directly into the mouth or throat. Leave the medicine in place for 15 seconds, then spit it out. Avoid swallowing the spray. Use once every 2 hours as needed.
To use Lugol as a mouth rinse, gargle or swish the liquid for 30 seconds, then spit it out. Do not swallow the liquid. Use up to 4 times per day.
You should not use Lugol for longer than 7 days without medical advice.
Call your doctor if your sore throat is severe or ongoing after 2 days, or if you also have a high fever, headache, nausea, and vomiting.
If you are using Lugol on your skin, seek medical advice if you have new or worsening symptoms of pain, redness, swelling, rash, or fever.
Store at room temperature away from moisture and heat. Do not freeze.
Each Lugol swab is for one use only.
Lugol can stain skin, teeth, and fabric. You may use rubbing alcohol to remove staining from your skin. Avoid getting alcohol onto a wound or irritated skin. Stains on fabric can be removed by rinsing with ammonia diluted with water. Avoid getting the medicine on jewelry, especially silver.
Lugol spray is flammable. Do not use near high heat or open flame. Do not smoke until the gel has completely dried on your skin.
Uses of Lugol in details
Use: Labeled Indications
Used topically as an antiseptic in the management of minor, superficial skin wounds and has been used to disinfect the skin preoperatively
Lugol description
Lugol as oral and topical/cutaneous formulations is prescribed for the treatment of Lugol deficiency disorders, pre-operative reduction of vascularity of thyroid glands, protection against radioactive Lugol, cutaneous or lymphocutaneous sporotrichosis, Grave’s disease, cleaning of minor or superficial wounds, thyroid storm and cleaning of wet wounds and ulcers.
Lugol dosage
Oral
Preoperative reduction of vascularity of the thyroid gland
Adult: As Lugol: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery.
Child: As Lugol: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery. As strong Lugol solution: 0.1-0.3 ml (or approx 3-5 drops) tid.
Reconstitution: Administer Lugol oral solution in a large quantity (240 ml) of water, or in fruit juice, milk formula or broth.
Oral
Grave's disease
Child: Neonates: 1 drop of strong Lugol solution every 8 hr.
Oral
Radiation protection against radioactive Lugol
Adult: As Lugol: 100-150 mg 24 hr before procedure and daily for up to 10 days after procedure.
Child: As Lugol: Infants from birth to 1 mth with a predicted thyroid exposure of ≥5 centigrays (cGy): 16 mg. >1 mth to 3 yr with a predicted thyroid exposure of ≥5 cGy: 32 mg. >3 yr to 18 yr (except adolescents approaching adult size) with a predicted thyroid exposure of ≥5 cGy: 65 mg. Do not exceed once-daily doses.
Reconstitution: 130-mg Tablet: Place 1 tablet in a small bowl and pulverise using a metal spoon. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 6.25 mg Lugol per 5 ml. 65-mg Tablet: Place 1 tablet in a small bowl and pulverise. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 8.125 mg Lugol per 5 ml.
Oral
Cutaneous or lymphocutaneous sporotrichosis
Adult: As Lugol solution containing 1 g/mL: Initially, 1 mL tid, should continue for at least 1 mth after disappearance or stabilisation of the lesions.
Child: As Lugol: Initially, 250 mg (approx 5 drops of a solution containing 1 g/ml) tid. Max: 1.25-2 g (approx 25-40 drops) tid. Duration: 3-6 mth.
Reconstitution: Administer Lugol solution in a large quantity (240 ml) of water, fruit juice, milk formula or broth.
Oral
Lugol deficiency disorders
Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Lugol): 400 mg Lugol once yrly. Pregnant patient: 200 mg Lugol as a single dose. Moderate to severe: 300-480 mg Lugol each yr or 100-300 mg Lugol every 6 mth and for at least 1 yr postpartum.
Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Lugol): Infants up to 1 yr: Single dose of 100 mg Lugol; 1-5 yr: 200 mg Lugol; >6 yr: 400 mg Lugol.
Oral
Thyroid storm
Adult: As Lugol: Up to 500 mg every 4 hr.
Intramuscular
Lugol deficiency disorders
Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Lugol): Up to 45 yr: 380 mg Lugol, as single IM doses to provide adequate protection from Lugol deficiency for up to 3 yr. Pregnant patient: Moderate to severe: 480 mg Lugol each yr.
Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Lugol): 380 mg Lugol, as single IM doses to provide adequate protection from Lugol deficiency for up to 3 yr. Infants up to 1 yr: 190 mg Lugol, as iodised oil (480 mg/ml Lugol).
Topical/Cutaneous
Minor, superficial skin wounds
Adult: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.
Child: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.
Topical/Cutaneous
Cleaning wet ulcers and wounds
Adult: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.
Child: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.
Lugol interactions
See also:
What other drugs will affect Lugol?
There is a potential risk of interaction with lithium, resulting in an increased possibility of hypothyroidism.
this medicineshould not be used concomitantly with mercurial antiseptics, e.g. mercurochrome and thiomersal.
Since Lugol may be absorbed systemically, the result of tests of the thyroid function can be influenced.
Lugol side effects
See also:
What are the possible side effects of Lugol?
Lugol and iodides, whether applied topically or given systemically, can give rise to hypersensitivity reactions which may include urticaria, angioedema, cutaneous haemorrhage or purpuras, fever, arthralgia, lymphadenopathy, and eosinophilia.
Inhalation of Lugol vapour is very irritating to mucous membranes.
Lugol and iodides have variable effects on the thyroid and can produce goitre and hypothyroidism as well as hyperthyroidism (the Iod-Basedow or Jod-Basedow phenomenon). Goitre and hypothyroidism have also occurred in infants born to mothers who had taken iodides during pregnancy.
Prolonged use may lead to a range of adverse effects, often called ’iodism’, some of which may again be due to hypersensitivity. Adverse effects include metallic taste, increased salivation, burning or painful mouth; there may be acute rhinitis, coryza-like symptoms, and swelling and inflammation of the throat. Eyes may be irritated and swollen and there may be increased lachrymation. Pulmonary oedema, dyspnoea, and bronchitis may develop. Skin reactions include acneform or, more rarely, severe eruptions (iododerma). Other reported effects include depression, insomnia, impotence, headache, and gastrointestinal disturbances, notably nausea, vomiting, and diarrhoea.
Lugol contraindications
Allergy to Lugol,
- Class III patients with Okuda
- Extrahepatic metastases,
- Respiratory or renal insufficiencies severe
- Cons-indications for hepatic arteriography,
- Leukopenia below 1500/mm3 or thrombocytopenia less 50000/mm3,
- Pregnant woman: Lugol should not be administered to pregnant women. In women of childbearing age, suspicion of pregnancy must be excluded before the administration of Lugol. Contraception must be instituted and prosecuted in the administration at least a year.
- Breastfeeding: Breastfeeding should be stopped.
Active ingredient matches for Lugol:
Iodine in Georgia, Japan, Switzerland.
Glycerol/Iodinated in Japan.
Iodine 5%/K iodide 10% in Thailand.
Potassium Iodide in Switzerland.
Potassium Iodide/Potassium Iodide/Potassium Iodide
List of Lugol substitutes (brand and generic names) | Sort by popularity |
Unit description / dosage (Manufacturer) | Price, USD |
LP-30 (India) | |
Lp-30 30mg CAP / 10 (Waves-Biotech) | $ 0.58 |
Lugol Solution with Glycerin | |
Solution; Local; Iodine 1% | |
Lugol's Solution | |
Liquid; Oral; Iodine / Potassium Iodide 5% | |
Lugola RFF (Latvia) | |
Lugolit-DF (Georgia) | |
Lugolum (Georgia) | |
Lugs (Georgia) | |
Luxspray (United Kingdom) | |
LuxVet (Switzerland) | |
LuxVet 50 S für Rinder, Schafe und Ziegen (Switzerland) | |
LuxVet 50S 5 mg/ml voor lacterende melkkoeien, schapen en geiten (Netherlands) | |
Lycol Syr (India) | |
Lycol Syr Lycopene 1000 mcg, vitamin A1600 IU, vitamin E 10 IU, vitamin C 50 mg, selenium 35mcg, manganese 2 mg, iodine100 mcg, copper 500 mcg, thiamine 2 mg, riboflavin 3mg, pyridoxine 1.5 mg/10 mL. SYR / 200ml (Olcare) | $ 1.45 |
Lycol Syr Lycopene 1000 mcg, vitamin A1600 IU, vitamin E 10 IU, vitamin C 50 mg, selenium 35mcg, manganese 2 mg, iodine100 mcg, copper 500 mcg, thiamine 2 mg, riboflavin 3mg, pyridoxine 1.5 mg/10 mL SYR / 200ml (Olcare) | $ 1.45 |
LYCOL SYR syr 200ml (Olcare) | $ 1.45 |
Maki | |
Maki Pediatric | |
Masocare (United Kingdom) | |
Masocare Extra (United Kingdom) | |
Masodine (United Kingdom) | |
Mastex (Ireland) | |
Mccf (India) | |
Mccf Vitamin A 5000 IU, vitamin B15 mg, vitamin B2 5 mg, vitaminB6 2 mg, mecobalamin 25 mcg, vitamin C 75 mg, vitamin D3400 IU, vitamin E acetate 15mg, nicotinamide 50 mg, calcium d-pantothenate 5 mg, folic acid 1 mg, copper 0.5mg, potassium sulphate 2 mg, ma (Am. Biocare) | $ 10.72 |
Mccf Vitamin A 5000 IU, vitamin B15 mg, vitamin B2 5 mg, vitaminB6 2 mg, mecobalamin 25 mcg, vitamin C 75 mg, vitamin D3400 IU, vitamin E acetate 15mg, nicotinamide 50 mg, calcium d-pantothenate 5 mg, folic acid 1 mg, copper 0.5mg, potassium sulphate 2 mg, ma (Am. Biocare) | $ 10.72 |
Mccf Vitamin A 5000 IU, vitamin B15 mg, vitamin B2 5 mg, vitaminB6 2 mg, mecobalamin 25 mcg, vitamin C 75 mg, vitamin D3400 IU, vitamin E acetate 15mg, nicotinamide 50 mg, calcium d-pantothenate 5 mg, folic acid 1 mg, copper 0.5mg, potassium sulphate 2 mg, ma (Am. Biocare) | $ 10.72 |
Mccf Vitamin A 5000 IU, vitamin B15 mg, vitamin B2 5 mg, vitaminB6 2 mg, mecobalamin 25 mcg, vitamin C 75 mg, vitamin D3400 IU, vitamin E acetate 15mg, nicotinamide 50 mg, calcium d-pantothenate 5 mg, folic acid 1 mg, copper 0.5mg, potassium sulphate 2 mg, ma (Am. Biocare) | $ 10.72 |
Mccf Vitamin A 5000 IU, vitamin B15 mg, vitamin B2 5 mg, vitaminB6 2 mg, mecobalamin 25 mcg, vitamin C 75 mg, vitamin D3400 IU, vitamin E acetate 15mg, nicotinamide 50 mg, calcium d-pantothenate 5 mg, folic acid 1 mg, copper 0.5mg, potassium sulphate 2 mg, ma (Am. Biocare) | $ 10.72 |
Mccf Vitamin A 5000 IU, vitamin B15 mg, vitamin B2 5 mg, vitaminB6 2 mg, mecobalamin 25 mcg, vitamin C 75 mg, vitamin D3400 IU, vitamin E acetate 15mg, nicotinamide 50 mg, calcium d-pantothenate 5 mg, folic acid 1 mg, copper 0.5mg, potassium sulphate 2 mg, ma (Am. Biocare) | $ 10.72 |
Mccf Vitamin A 5000 IU, vitamin B15 mg, vitamin B2 5 mg, vitaminB6 2 mg, mecobalamin 25 mcg, vitamin C 75 mg, vitamin D3400 IU, vitamin E acetate 15mg, nicotinamide 50 mg, calcium d-pantothenate 5 mg, folic acid 1 mg, copper 0.5mg, potassium sulphate 2 mg, ma (Am. Biocare) | $ 10.72 |
MCCF cap 10x15 (Am. Biocare) | $ 10.72 |
Mccf Vitamin A 5000 IU, vitamin B15 mg, vitamin B2 5 mg, vitaminB6 2 mg, mecobalamin 25 mcg, vitamin C 75 mg, vitamin D3400 IU, vitamin E acetate 15mg, nicotinamide 50 mg, calcium d-pantothenate 5 mg, folic acid 1 mg, copper 0.5mg, potassium sulphate 2 mg, ma (Am. Biocare) | $ 10.72 |
Mccf Vitamin A 5000 IU, vitamin B15 mg, vitamin B2 5 mg, vitaminB6 2 mg, mecobalamin 25 mcg, vitamin C 75 mg, vitamin D3400 IU, vitamin E acetate 15mg, nicotinamide 50 mg, calcium d-pantothenate 5 mg, folic acid 1 mg, copper 0.5mg, potassium sulphate 2 mg, ma (Am. Biocare) | $ 10.72 |
Megodine (United Kingdom) | |
Metadyne (Canada) | |
Liquid; Topical; Iodine / Povidone-Iodine 1% (Pharmavite) | |
Microiodid (Russia) | |
Tablet; Oral; Potassium Iodide 130.8 mcg (Tatkhimfarmpreparaty) | |
Microiodide | |
Tablet; Oral; Potassium Iodide 130.8 mcg | |
Mikroplex Jod (Germany) | |
Milk-Line Teat Plus (United Kingdom) | |
Minostoss (Brazil) | |
MM Tosse (Brazil) | |
Modyne | |
Solution; Disinfectant / Barn; Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex 1.75% | |
Monarch Full Dip Teat Dip | |
Liquid; Teat-Dip; Iodine / Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex Complex 1% | |
Monarch Low Acid Udder Wash | |
Liquid; Udder Wash; Iodine / Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex Complex 1.75% | |
Monarch Mon O Dine | |
Liquid; Udder Wash; Iodine / Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex Complex 1.75% | |
See 635 substitutes for Lugol |
References
- DailyMed. "AMINO ACIDS; CALCIUM ACETATE; GLYCERIN; MAGNESIUM ACETATE; PHOSPHORIC ACID; POTASSIUM CHLORIDE; SODIUM ACETATE; SODIUM CHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "POTASSIUM IODIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "glycerol". https://pubchem.ncbi.nlm.nih.gov/sub... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Lugol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lugol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology