Milcopen indications
Oral
Streptococcal infections of the upper respiratory tract, including scarlet fever and erysipelas
Adult: 125-250 mg 6-8 hrly for 10 days.
Oral
Fusospirochetosis (Vincent's infection) of the oropharynx, Staphylococcal infections of the skin and soft tissue
Adult: 250-500 mg 6-8 hrly.
Oral
Pneumococcal infections of the respiratory tract, including otitis media
Adult: 250-500 mg 6 hrly until the patient is afebrile for at least 2 days.
Child: <1 yr 62.5 mg 6 hrly; 1-5 yr 125 mg 6 hrly; 6-12 yr 250 mg 6 hrly.
Oral
Prophylaxis of recurrent rheumatic fever
Adult: 250 mg bid.
Child: <1 yr 62.5 mg 6 hrly; 1-5 yr 125 mg 6 hrly; 6-12 yr 250 mg 6 hrly.
Oral
Susceptible infections
Adult: 250-500 mg 6 hrly.
Child: <1 yr 62.5 mg 6 hrly; 1-5 yr 125 mg 6 hrly; 6-12 yr 250 mg 6 hrly.
Milcopen description
Milcopen (Penicillin V) is narrow spectrum antibiotic used to treat mild to moderate infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered orally. Penicillin V may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (S. agalactiae), S. viridans, and Enterococcus faecalis. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as Bacillus anthracis, Corynebacterium diphtheriae, and Erysipelothrix rhusiopathiae. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by Neisseria meningitidis and Pasteurella. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
Milcopen dosage
Adults: 250-500 mg every 6 hrs.
Children: Suggested dosage for infants and children is 50 mg/kg body weight/day in 4 divided doses. To be given every 6 hrs.
Children 7-12 years: 5-10 mL (1-2 tsp) of Milcopen 250 mg/5 mL; 3-6 years: 5-10 mL (1-2 tsp) of Milcopen 125 mg/5 mL or 5 mL (1 tsp) of Milcopen 250 mg/5 mL; 1-2 years: 5 mL (1 tsp) of Milcopen 125 mg/5 mL or 2.5-5 mL of Milcopen 250 mg/5 mL.
Usual duration of therapy is from 10-14 days. Or as prescribed by the physician.
Milcopen interactions
Milcopen should not be combined with bacteriostatic antibiotics. Combinations with other antibiotics should be considered if their effects can be expected to be synergistic or at least additive. The combination partners should be fully dosed. (Exception: In combination with a proven synergistic action, the dose of the more toxic combination partner may be reduced.) Competitive inhibition of drug elimination should be remembered, whenever anti-inflammatories, antirheumatics, antipyretics (particularly indomethacin, phenylbutazone, salicylates in high doses) or probenecid are used concomitantly. Ingestion of Milcopen with meals reduce the absorption of the drug. Like other antibiotics, Milcopen may reduce the efficacy of oral contraceptives. During treatment with Milcopen non-enzymatic urinary glucose tests and uribilinogen tests may be false-positive. Urinary amino acid quantitations with ninhydrin may also be false-positive.
Milcopen side effects
Milcopen may produce diarrhoea, nausea and heartburn. Allergic reactions which may include exfoliative dermatitis, other skin rashes, interstitial nephritis and vasculitis, may occur.
A generalised sensitivity reaction with urticaria, fever, joint pains and eosinophilia can develop within a few hours to several weeks after starting treatment. Superinfection by resistant species, such as Pseudomonas or Candida, which do not respond to penicillin therapy may occur. A sore mouth and a black hairy tongue have been reported.
Increases in liver enzyme values have been reported. Care should be taken when high doses are given to patients with renal impairment (because of the risk of neurotoxicity) or congestive heart failure.
Renal and haematological systems should be monitored during prolonged and high dose therapy.
Care should be taken when treating patients with syphilis, as the Jarisch-Herxheimer reaction may occur shortly after starting treatment. This reaction, manifesting as fever, chills, headache and reactions at the site of the lesion, can be dangerous in cardiovascular syphilis or where there is a serious risk of increased local damage such as with optic atrophy.
Haemolytic anaemia and leucopenia, prolongation of bleeding time and defective platelet function have been observed. Convulsions and other signs of toxicity to the CNS may occur particularly in patients with renal failure.
Disturbances of blood electrolytes may follow the administrations of large doses of this medicine.
High doses should be used with caution in patients receiving potassium containing medicines or potassium-sparing diuretics.
Milcopen contraindications
Milcopen should not be given to patients known to be allergic to penicillin and should be given with care to patients with a history of allergy to cephalosporins. Cases of cross sensitivity have been reported. It should not be given to babies, in the neonatal period, born of hypersensitive mothers. It is not recommended for chronic, severe or deep-seated infections such as subacute bacterial endocarditis, meningitis or syphilis.
Active ingredient matches for Milcopen:
Phenoxymethylpenicillin in Finland.
Phenoxymethylpenicillin potassium in Finland.
List of Milcopen substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Microfen (Italy) | |
| Mobiot (Peru) | |
| Nadopen-v (Canada) | |
| Open (Bangladesh) | |
| Open 100mg TAB / 10 (Zee Laboratories Ltd) | |
| Open 200mg TAB / 10 (Zee Laboratories Ltd) | |
| Open 400mg TAB / 10 (Zee Laboratories Ltd) | |
| 1 g x 1's (Zee Laboratories Ltd) | $ 26.39 |
| Open 1000 mg Injection (Zee Laboratories Ltd) | $ 0.02 |
| Open 100 mg Tablet (Zee Laboratories Ltd) | $ 0.04 |
| Open 400 mg Tablet (Zee Laboratories Ltd) | $ 0.12 |
| Open 200 mg Tablet (Zee Laboratories Ltd) | $ 0.06 |
| Open Eye 5 ml Drop (Zee Laboratories Ltd) | $ 0.09 |
| Open 1g VIAL / 1 (Zee Laboratories Ltd) | $ 26.39 |
| OPEN 200MG TABLET 1 strip / 10 tablets each (Zee Laboratories Ltd) | $ 0.54 |
| Open 200mg Tablet (Zee Laboratories Ltd) | $ 0.05 |
| Open NA Eye Drop (Zee Laboratories Ltd) | $ 0.53 |
| Oracilina (Peru) | |
| Oracilline (France, Luxembourg, Tunisia) | |
| Suspension; Oral; Penicillin V Benzathine Lecithin 50, 000 IU / ml (Aventis) | |
| Suspension; Oral; Penicillin V Benzathine Lecithin 100, 000 IU / ml (Aventis) | |
| Tablet; Oral; Penicillin V 1, 000, 000 IU (Aventis) | |
| Oracyn-K (Bangladesh) | |
| Ospa-V (Yemen) | |
| Ospaine 1,000 | |
| Ospaine 400 | |
| Ospaine 500 | |
| Ospen (Austria, Bahrain, Bosnia & Herzegowina, Costa Rica, Cyprus, Czech Republic, Dominican Republic, El Salvador, Estonia, Georgia, Greece, Guatemala, Hungary, Indonesia, Jordan, Kuwait, Latvia, Lebanon, Lithuania, Nicaragua, Oman, Panama, Poland, Qatar, Romania, Russian Federation, Saudi Arabia, Singapore, Slovakia, Slovenia, Sudan, Switzerland, Tunisia, United Arab Emirates, Yemen) | |
| Suspension; Oral; Penicillin V Potassium 400, 000 IU / 5 ml (Biochemie) | |
| Suspension; Oral; Penicillin V Potassium 750, 000 IU / 5 ml (Biochemie) | |
| Syrup; Oral; Penicillin V Potassium 400, 000 IU / 5 ml (Biochemie) | |
| Syrup; Oral; Penicillin V Potassium 750, 000 IU / 5 ml (Biochemie) | |
| Tablet, Film-Coated; Oral; Penicillin V Potassium 1, 000, 000 IU (Biochemie) | |
| Tablet, Film-Coated; Oral; Penicillin V Potassium 1, 500, 000 IU (Biochemie) | |
| Tablet, Film-Coated; Oral; Penicillin V Potassium 500, 000 IU (Biochemie) | |
| Ospen 250 mg x 10 x 10's (Biochemie) | $ 15.10 |
| Ospen 625 mg x 10 x 10's (Biochemie) | $ 29.76 |
| Ospen 250 mg/5 mL x 60 mL x 1's (Biochemie) | $ 3.76 |
| Ospen 250 mg x 1000's (Biochemie) | |
| Ospen 625 mg x 1000's (Biochemie) | |
| Ospen 1 MIU x 1000's (Biochemie) | |
| Ospen 1 MIU x 100 Blister x 10 Tablet (Biochemie) | |
| Ospen 1 MIU x 12 Tablet (Biochemie) | |
| Ospen 1 MIU x 30 Tablet (Biochemie) | |
| Ospen 1 000 000 NE (Bulgaria, Hungary) | |
See 337 substitutes for Milcopen | |
Reviews
The results of a survey conducted on ndrugs.com for Milcopen are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Milcopen. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
