Permyo indications
Spastic paralysis in cerebrovascular disease, spastic spinal paralysis, cervical spondylosis, post-op sequelae (including cerebrovascular tumor), sequelae to trauma (eg, spinal trauma, head injury), amyotrophic lateral sclerosis, cerebral palsy, spinocerebellar degeneration, spinal vascular diseases & other encephalomyelopathies. Improvement of muscular hypertonic symptoms in conditions eg, cervical syndrome, periarthritis of the shoulder, lumbago.
Uses of Permyo in details
Permyo is used to relieve muscle stiffness and pain (muscle spasm) in several conditions including low back pain, painful conditions of neck, shoulder and arm and in spastic paralysis (weakness and stiffness of muscles causing loss or impairment of movement).
Permyo description
Permyo is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex. It is not approved for use in the United States, but is available in other countries like India, South Korea, and Bangladesh.
Permyo dosage
Adult Muscle relaxant 1 tab tid. Spastic paralysis 1-2 tab tid.
Permyo interactions
Permyo appears to decrease the rate at which certain drugs are metabolized and therefore may increase the blood levels and the possibility of clinical toxicity of drugs given concomitantly.
DISULFIRAM SHOULD BE USED WITH CAUTION IN THOSE PATIENTS REVEIVING PHENYTOIN AND ITS CONGENERS. SINCE THE CONCOMITANT ADMINISTRATION OF THESE TWO DRUGS CAN LEAD TO PHENYTOIN INTOXICATION, PRIOR TO ADMINISTERING DISULFIRAM TO A PATIENT ON PHENYTOIN THERAPY, A BASELINE PHENYTOIN SERUM LEVEL SHOULD BE OBTAINED. SUBSEQUENT TO INITIATION OF DISULFIRAM THERAPY. SERUM LEVELS OF PHENYTOIN SHOULD BE DETERMINED ON DIFFERENT DAYS FOR EVIDENCE OF AN INCREASE OR FOR A CONTINUING RISE IN LEVELS. INCREASED PHENYTOIN LEVELS SHOULD BE TREATED WITH APPROPRIATE DOSAGE ADJUSTMENT.
It may be necessary to adjust the dosage of oral anticoagulants upon beginning or stopping disulfiram. since disulfiram may prolong prothrombin time.
Patients taking isoniazid when disulfiram is given should be observed for the appearance of unsteady gait or marked changes in mental status; the disulfiram should be discontinued if such signs appear.
In rats, simultaneous ingestion of disulfiram and nitrite in the diet for 78 weeks has been reported to cause tumors, and it has been suggested that disulfiram may react with nitrites in the rat stomach to form a nitrosamine, which is tumorigenic. Permyo alone in the ratÃs diet did not lead to such tumors. The relevance of this finding to humans is not known at this time.
Permyo side effects
Liver or kidney function impairment; erythrocyte or Hb count abnormalities, skin rash, insomnia, headache, drowsiness, stiffness, numbness & trembling of extremities, nausea, vomiting, anorexia, gastric discomfort, dry mouth, constipation, diarrhea/soft stool, abdominal pain, full abdominal sensation, urinary disorders, weakness, dizziness, fatigue, flushing, sweating.
Permyo contraindications
Patients who are receiving or have recently received metronidazole. paraldehyde. alcohol, or alcohol-containing preparations, e.g. cough syrups, tonics and the like, should not be given disulfiram.
Permyo is contraindicated in the presence of severe myocardial disease or coronary occlusion, psychoses, and hypersensitivity to disulfiram or to other thiuram derivatives used in pesticides and rubber vulcanization.
Active ingredient matches for Permyo:
Eperisone in Indonesia.
Eperisone HCl in Indonesia.
Eperisone hydrochloride in Indonesia.
| Unit description / dosage (Manufacturer) | Price, USD |
| Permyo 50 mg x 50's | $ 18.60 |
List of Permyo substitutes (brand and generic names): | |
| Myorelark (Japan) | |
| Myori (Indonesia) | |
| Myori 50 mg x 5 x 10's (Tempo scan pacific) | $ 10.85 |
| MYOSONE (India) | |
| 50 mg x 10's (Macleods (Osteva)) | |
| Myosone 50mg FC-TAB / 10 (Macleods (Osteva)) | $ 0.63 |
| Myosone 150mg TAB / 10 (Macleods (Osteva)) | $ 1.81 |
| MYOSONE 50 MG TABLET 1 strip / 10 tablets each (Macleods (Osteva)) | $ 0.91 |
| MYOSONE SR 150 MG TABLET 1 strip / 10 tablets each (Macleods (Osteva)) | $ 2.40 |
| MYOSONE film-coated tab 50 mg x 10's (Macleods (Osteva)) | $ 0.63 |
| MYOSONE SR tab 150 mg x 10's (Macleods (Osteva)) | $ 1.99 |
| Myosone 50mg FC-TAB / 10 (Macleods (Osteva)) | $ 0.63 |
| Myosone 150mg TAB / 10 (Macleods (Osteva)) | $ 1.81 |
| Myosone 150mg Tablet SR (Macleods (Osteva)) | $ 0.26 |
| Myosone 50mg Tablet (Macleods (Osteva)) | $ 0.10 |
| Mysobenal (Vietnam) | |
| Mysolax (Vietnam) | |
| Mysolax 50 mg x 10 Blister x 10 Tablet | |
| Perispa (Philippines) | |
| Perispa 50 mg x 30's (Platinum Pharma) | $ 0.33 |
| Perispa tab 50 mg 30's (Platinum Pharma) | $ 0.33 |
| Ralexa (Thailand) | |
| Ralexa 50 mg x 3 x 10's | |
| RAPISONE (India) | |
| 50 mg x 10's (AHPL) | $ 0.57 |
| Rapisone 50mg TAB / 10 (AHPL) | $ 0.63 |
| RAPISONE 150 MG CAPSULE SR 1 strip / 5 capsule srs each (AHPL) | $ 1.40 |
| RAPISONE tab 50 mg x 10's (AHPL) | $ 0.63 |
| Rapisone 50mg TAB / 10 (AHPL) | $ 0.63 |
| Rapisone 150mg Capsule SR (AHPL) | $ 0.31 |
| Rinpral (Japan) | |
| Rizonax (Indonesia) | |
| Rizonax 50 mg x 3 x 10's (Novell Pharma) | $ 10.54 |
| SaVi Eperisone 50 (Vietnam) | |
| SKELACT (India) | |
| 50 mg x 10's (Sun Pharmaceutical Industries Ltd.) | $ 0.61 |
| Skelact 50 mg Tablet (Sun Pharmaceutical Industries Ltd.) | $ 0.06 |
| Skelact 50mg TAB / 10 (Sun Pharmaceutical Industries Ltd.) | $ 0.66 |
| SKELACT tab 50 mg x 10's (Sun Pharmaceutical Industries Ltd.) | $ 0.66 |
| Skelact 50mg TAB / 10 (Sun Pharmaceutical Industries Ltd.) | $ 0.66 |
| Skeson (Vietnam) | |
| Skeson 50 mg x 10 Blister x 10 Tablet | |
| Sunbazon (Japan) | |
| Taiguk Eperisone (South Korea) | |
| Tolmynal (Japan) | |
| Ton-dine (Vietnam) | |
| Ton-dine 50 mg x 10 Blister x 10 Tablet | |
| Yi Yu (China) | |
| Zonal (Indonesia) | |
| Zonal 50 mg x 10 x 10's (Kalbe Farma) | $ 24.80 |
| Zonaxson (Vietnam) | |
| Zonaxson 50 mg x 3 Blister x 10 Tablet | |
| Zuo Ning (China) | |
See 145 substitutes for Permyo | |
References
- PubChem. "eperisone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Eperisone". http://www.drugbank.ca/drugs/DB08992 (accessed September 17, 2018).
- MeSH. "Parasympatholytics". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Permyo are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Permyo. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
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Information checked by Dr. Sachin Kumar, MD Pharmacology
