Reclofen Uses

• Reclofen indications
• Uses of Reclofen in details
• Reclofen description
• Reclofen dosage
• Reclofen interactions
• Reclofen side effects
• Reclofen contraindications

What is Reclofen?

Reclofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and other symptoms of arthritis of the joints (eg, osteoarthritis), such as inflammation, swelling, stiffness, and joint pain. However, Reclofen does not cure osteoarthritis and will help you only as long as you continue to use it.

Reclofen topical 3% gel is also used to treat actinic keratosis, a skin problem that may become cancerous if not treated. The exact way that topical Reclofen helps this condition is unknown.

Reclofen topical solution is used to treat pain and swelling caused by osteoarthritis of the knees.

Reclofen topical patch is used to treat acute pain caused by minor strains, sprains, and contusions (bruises).

Reclofen is available only with your doctor's prescription.

Reclofen indications

Intramuscular

Renal colic

Adult: As Reclofen Na: 75 mg, may repeat once after 30 min if needed. Max: 150 mg/day. Max period: 2 days.

Intramuscular

Bursitis, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis, Acute gout, Dysmenorrhoea

Adult: As Reclofen Na: 75 mg once daily, injected into the gluteal muscle, may increase to 75 mg bid in severe conditions. Max period: 2 days.

Intravenous

Postoperative pain

Adult: As Reclofen Na: 75 mg infusion in glucose 5% or NaCl 0.9% (previously buffered w/ Na bicarbonate) given over 30-120 min or as bolus inj, may repeat after 4-6 hr if necessary. Max period: 2 days.

Intravenous

Prophylaxis of postoperative pain

Adult: As Reclofen Na: Initially, 25-50 mg infusion given after surgery over 15-60 min followed by 5 mg/hr. Alternatively, initial dose may be given as bolus inj over 5-60 sec followed by additional inj, may repeat after 4-6 hr if necessary. Max: 150 mg/day. Max period: 2 days.

Ophthalmic

Postoperative ocular inflammation

Adult: As Reclofen Na (0.1% soln): Instill into the appropriate eye 4 times daily starting 24 hr after surgery for up to 28 days.

Ophthalmic

Inflammation and discomfort after strabismus surgery

Adult: As Reclofen Na (0.1% soln): Instill 1 drop 4 times daily for the 1st wk; then tid in the 2nd wk, bid in the 3rd wk, and as required for the 4th wk.

Ophthalmic

Pain and discomfort after radial keratotomy

Adult: As Reclofen Na (0.1% soln): Instill 1 drop before surgery followed by 1 drop immediately after surgery, and then 1 drop 4 times daily for up to 2 days.

Ophthalmic

Pain after accidental trauma

Adult: As Reclofen Na (0.1% soln): Instill 1 drop 4 times daily for up to 2 days.

Ophthalmic

Control of inflammation after argon laser trabeculoplasty

Adult: As Reclofen Na (0.1% soln): Instill 1 drop 4 times during the 2 hr before procedure followed by 1 drop 4 times daily, up to 7 days after procedure.

Ophthalmic

Prophylaxis of intra-operative miosis

Adult: As Reclofen Na (0.1% soln): Instill into appropriate eye 4 times w/in 2 hr before surgery.

Ophthalmic

Post-photorefractive keratectomy pain

Adult: As Reclofen Na (0.1% soln): Instill into the affected eye twice, an hr before surgery, then 1 drop twice at 5-min intervals immediately after surgery, then every 2-5 hr while awake for up to 24 hr.

Ophthalmic

Seasonal allergic conjunctivitis

Adult: As Reclofen Na (0.1% soln): Instill 1 drop before surgery followed by 1 drop immediately after surgery, and then 1 drop 4 times daily for up to 2 days.

Oral

Bursitis, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis, Acute gout, Dysmenorrhoea

Adult: As Reclofen Na: 75-150 mg/day in divided doses. Max: 150 mg/day.

Oral

Migraine

Adult: As Reclofen K: Initially, 50 mg taken at the 1st sign of an attack, an additional dose of 50 mg may be taken after 2 hr if symptoms persist. If needed, further doses of 50 mg may be taken 4-6 hrly. Max: 200 mg/day.

Rectal

Acute gout, Bursitis, Dysmenorrhoea, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis

Adult: As Reclofen Na: 100 mg once daily.

Topical/Cutaneous

Actinic keratoses

Adult: As Reclofen Na (3% gel): Apply bid for 60-90 days.

Topical/Cutaneous

Osteoarthritis

Adult: As Reclofen Na (1.6% soln): Apply in small amounts (20 or 40 drops) onto affected area 4 times daily. As Na: (1% gel): Apply to the affected area 4 times daily. Max: 32 g/day over the affected area.

Topical/Cutaneous

Local symptomatic relief of pain and inflammation

Adult: As Reclofen Na (1% gel): Apply onto affected area 3 or 4 times daily.

Transdermal

Acute pain

Adult: Sprains, strains, contusions: 1 patch bid.

How should I use Reclofen?

Use Reclofen solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Reclofen solution comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Reclofen solution refilled.
• Do not apply Reclofen solution to infected skin; open wounds; or red, swollen, or peeling skin.
• Wash your hands immediately before and after using Reclofen solution.
• Wash the affected area and dry completely before using Reclofen solution.
• To apply Reclofen solution, dispense 10 drops at a time onto the knee or into your hand. Spread Reclofen solution evenly around the front, back, and sides of the knee. Repeat until you have used the whole dose.
• Be sure that you cover your entire knee with your dose of Reclofen solution. Do not use more than the recommended amount.
• Do not apply sunscreens, cosmetics, insect repellants, other topical medicines, or any other substance to the treated area until it is completely dry.
• Do not put on clothes over the treated area until it is completely dry.
• Do not wrap, bandage, or apply heat to the treated area.
• Let the treated skin dry before touching it or letting it touch anyone else's skin.
• Do not shower, bathe, or wash the treated area for at least 30 minutes after you use Reclofen solution.
• If you miss a dose of Reclofen solution, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Reclofen solution.

Uses of Reclofen in details

Reclofen is used to relieve pain from various conditions. This form of Reclofen is used to treat migraine headaches. Reclofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat gout attacks.

How to use Reclofen

Read the Medication Guide provided by your pharmacist before you start taking Reclofen and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor. Empty the contents of one packet into a cup containing 1 to 2 ounces (30 to 60 milliliters) of water. Mix well and drink all of it right away. Do not mix with any liquid other than water. If stomach upset occurs while taking this medication, take it with food, milk, or an antacid. However, if you take this medication with a meal high in fat, it may not work as well.

There are different brands and forms of this medication available. Because different forms do not have the same effects at equal strengths, do not switch forms of Reclofen unless your doctor tells you to.

To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose. Do not increase your dose or take it more often than prescribed.

Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Tell your doctor if your condition persists or worsens.

Reclofen description

The active substance is sodium-[o[(2,6-dichlorophenyl)-amino]-phenyl]-acetate (= Reclofen).

Each enteric tablet contains 25 mg or 50 mg of Reclofen.

One prolonged-release tablet contains 100 mg of Reclofen.

Excipients/Inactive Ingredients: Gastro-Resistant Tablet: Core for 25 mg and 50 mg: Cellulose microcrystalline; lactose monohydrate; magnesium stearate; maize starch; povidone; silica, colloidal anhydrous; sodium starch glycolate (type A).

Coating for 25 mg and 50 mg: Hypromellose; iron oxide yellow (E172); macrogoglycerol hydroxystearate; methacrylic acid-ethyl acrylate copolymer; macrogol 8000; talc; titanium dioxide (E171); simeticone; alpha-octadecyl-omega-hydroxy-polyglykolether; sorbic acid.

Coating for 50 mg: Iron oxide red (E172).

SR Tablet: Tablet Core: Cetyl alcohol; magnesium stearate; povidone; silica; colloidal anhydrous; sucrose.

Tablet Coating: Hypromellose; iron oxide red (E172); macrogol 8000; polysorbate 80; sucrose; talc; titanium dioxide (E171). Printing Ink: Carbon black, shellac, ammonium hydroxide, simethicone.

Injection: Each ampoule also contains the following excipients: Mannitol, sodium metabisulfite (E223), benzyl alcohol, propylene glycol, water for injection, sodium hydroxide.

Reclofen dosage

General Dosing Instructions

Carefully consider the potential benefits and risks of Reclofen and other treatment options before deciding to use Reclofen. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.

The effectiveness of Reclofen when taken with food has not been studied in clinical studies. Taking Reclofen with food may cause a reduction in effectiveness compared to taking Reclofen on an empty stomach.

Acute Pain

For management of mild to moderate acute pain, the dosage is 18 mg or 35 mg orally three times daily.

Osteoarthritis Pain

For management of osteoarthritis pain, the dosage is 35 mg orally three times daily.

Dosage Adjustments in Patients with Hepatic Impairment

Patients with hepatic disease may require reduced doses of Reclofen compared to patients with normal hepatic function. As with other Reclofen products, start treatment at the lowest dose. If efficacy is not achieved with the lowest dose, discontinue use.

Non-Interchangeability with Other Formulations of Reclofen

Reclofen capsules are not interchangeable with other formulations of oral Reclofen even if the milligram strength is the same. Reclofen capsules contain Reclofen free acid whereas other Reclofen products contain a salt of Reclofen, i.e., Reclofen potassium or sodium. A 35 mg dose of Reclofen is approximately equal to 37.6 mg of sodium Reclofen or 39.5 mg of potassium Reclofen. Therefore, do not substitute similar dosing strengths of other Reclofen products without taking this into consideration.

Reclofen interactions

See also:
What other drugs will affect Reclofen?

Aspirin: Concomitant administration of Reclofen and aspirin is not recommended because Reclofen is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations, peak plasma levels and AUC values.

Anticoagulants: While studies have not shown Reclofen to interact with anticoagulants of the warfarin type, caution should be exercised, nonetheless, since interactions have been seen with other NSAIDs. Because prostaglandins play an important role in hemostasis and NSAIDs affect platelet function as well, concurrent therapy with all NSAIDs, including Reclofen and warfarin, requires close monitoring of patients to be certain that no change in their anticoagulant dosage is required.

Digoxin, Methotrexate, Cyclosporine: Reclofen, like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs. Ingestion of Reclofen may increase serum concentrations of digoxin and methotrexate and increase cyclosporine's nephrotoxicity. Patients who begin taking Reclofen or who increase their Reclofen dose or any other NSAID while taking digoxin, methotrexate or cyclosporine may develop toxicity characteristics for these drugs. They should be observed closely, particularly if renal function is impaired. In the case of digoxin, serum levels should be monitored.

Lithium: Reclofen decreases lithium renal clearance and increases lithium plasma levels. In patients taking Reclofen and lithium concomitantly, lithium toxicity may develop.

Oral Hypoglycemics:

Reclofen does not alter glucose metabolism in normal subjects nor does it alter the effects of oral hypoglycemic agents. There are rare reports, however, from marketing experiences, of changes in effects of insulin or oral hypoglycemic agents in the presence of Reclofen that necessitated changes in the doses of such agents. Both hypo- and hyperglycemic effects have been reported. A direct causal relationship has not been established, but physicians should consider the possibility that Reclofen may alter a diabetic patient's response to insulin or oral hypoglycemic agents.

Diuretics: Reclofen and other NSAIDs can inhibit the activity of diuretics. Concomitant treatment with potassium-sparing diuretics may be associated with increased serum potassium levels.

Other Drugs: In small groups of patients (7-10/interaction study), the concomitant administration of azathioprine, gold, chloroquine, D-penicillamine, prednisolone, doxycycline or digitoxin did not significantly affect the peak levels and AUC values of Reclofen. Phenobarbital toxicity has been reported to have occurred in a patient on chronic phenobarbital treatment following the initiation of Reclofen therapy.

Reclofen side effects

See also:
What are the possible side effects of Reclofen?

There have been cases reported of Reclofen being associated with the development of symptoms resembling the syndrome of inappropriate antidiuretic hormone secretion in elderly women. A patient who had been taking Reclofen for several years and had increasingly complained of dry, gritty eyes noticed that eye irritation disappeared within 3 days when Reclofen had to be discontinued because of GI effects.

The most frequent adverse effects reported in patients given Reclofen are GI in nature. Typical reactions include epigastric pain, nausea, vomiting and diarrhoea. Rarely, peptic ulcer and GI bleeding have occurred. Reclofen has also been implicated as the causative agent in colonic ulceration, small bowel perforation and pseudomembranous colitis.

Renal papillary necrosis and nephritic syndrome have been reported in patients taking Reclofen. Elevations of serum aminotransferase activity and clinical hepatitis, including fetal fulminant hepatitis have occurred in patients taking Reclofen. Self-limiting skin reaction eg, rash or pruritus may occur in patients given Reclofen.

Aspirin-sensitive asthmatic patients have developed reactions (rhinorrhoea, tightness of chest, wheezing, dyspnoea) when challenged with Reclofen in doses of 10-25 mg and the CMS in the UK have received a report of 1 aspirin-sensitive patient who died from acute asthma 4 hrs after a single 25-mg dose of Reclofen.

Reclofen contraindications

See also:
What is the most important information I should know about Reclofen?

Hypersensitivity to Reclofen or to any of the excipients of Reclofen.

Active gastric or intestinal ulcer, bleeding or perforation.

Last trimester of pregnancy.

Hepatic, renal and severe cardiac failure.

Patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid and/or other drugs with prostaglandin-synthetase inhibitory activity.

Treatment of peri-operative pain in setting of coronary artery bypass graft (CABG) surgery.

The use of high dose Reclofen (150 mg/day) for >4 weeks is contraindicated in patients with established cardiovascular disease (congestive heart failure, established ischemic heart disease, peripheral arterial disease) or uncontrolled hypertension.

Established Cardiovascular Disease or Significant Cardiovascular Risk Factors: The use of high dose Reclofen (150mg/day) for >4 weeks is contraindicated in patients with established cardiovascular disease (congestive heart failure, established ischemic heart disease, peripheral arterial disease) or uncontrolled hypertension. If Reclofen treatment is needed, patients with established cardiovascular disease, uncontrolled hypertension or significant cardiovascular risk factors (eg, hypertension, hyperlipidaemia, diabetes mellitus and smoking) should be treated only after careful consideration and at doses ≤100 mg daily if the treatment is for >4 weeks. As the cardiovascular risks of Reclofen may increase with dose and duration of exposure, Reclofen should always be prescribed at the lowest effective daily dose and for the shortest duration possible.

Renal Impairment: Reclofen is contraindicated in patients with renal failure. No specific studies have been carried out in patients with renal impairment, therefore, no specific dose adjustment recommendations can be made. Caution is advised when administering Reclofen to patients with mild to moderate renal impairment.

Hepatic Impairment: Reclofen is contraindicated in patients with hepatic failure. No specific studies have been carried out in patients with hepatic impairment, therefore, no specific dose adjustment recommendations can be made. Caution is advised when administering Reclofen to patients with mild to moderate hepatic impairment.

Active ingredient matches for Reclofen:

Diclofenac in Indonesia.

Diclofenac Na in Indonesia.

Diclofenac sodium in Indonesia.

Unit description / dosage (Manufacturer)	Price, USD
Reclofen 25 mg x 100's	$ 8.87
Reclofen 50 mg x 100's	$ 16.03
List of Reclofen substitutes (brand and generic names):
REAL
REAL POWDER 1 box / 250 GM powder each (Scorsis Laboratories)	$ 1.64
RECONAC (India)
RECONAC inj 25 mg x 1 mL x 3ml (Schon (Reco))	$ 0.06
Rectos (Japan)
Rediclon (Turkey)
Redirinse (India)
Redirinse Diclofenac 0.074%w/v - / 120ml (Elder)	$ 0.78
REDIRINSE 0.07% LIQUID 1 bottle / 120 ML liquid each (Elder)	$ 0.77
REDIRINSE mouthwash 0.074 % w/v x 120ml (Elder)	$ 0.78
Redirinse 0.07% Liquid (Elder)	$ 0.77
Refain (Bangladesh)
Refain-TR (Bangladesh)
Refen (Romania, Taiwan)
Refen 200 mg (Stada hemofarm)
Refen Retard (Romania)
Regunac (India)
Regunac 50mg CAP / 10 (Unijules)	$ 0.24
50 mg x 10's (Unijules)	$ 0.24
REGUNAC enteric-coated cap 50 mg x 10's (Unijules)	$ 0.24
Regunac-DR (India)
Regunac-DR Diclofenac Na/ EC 25mg, Diclofenac Na/ SR 75mg CAP / 10 (Unijules)	$ 0.48
10's (Unijules)	$ 0.48
REGUNAC-DR cap 10's (Unijules)	$ 0.48
Relaflex 50 (Paraguay)
Relaxyl (India)
Relaxyl Diclofenac Sodium 50mg TAN / 10 (Franco-Indian)	$ 0.14
RELAXYL 100 MG TABLET SR 1 strip / 10 tablet srs each (Franco-Indian)	$ 0.31
RELAXYL 50 MG TABLET 1 strip / 10 tablets each (Franco-Indian)	$ 0.19
RELAXYL oint 30g (Franco-Indian)	$ 0.42
Relaxyl 100mg Tablet SR (Franco-Indian)	$ 0.03
Relaxyl 50mg Tablet (Franco-Indian)	$ 0.02
Relaxyl DA
Relaxyl DA Diclofenac diethylamine 1.16 %w/w, methyl salicylate 5 %w/w, mephenesin 10 % w/w, linseed oil 3 % w/w, capsaicin0.025 % w/w, menthol 5 % w/w. GEL / 30g	$ 0.60
Relaxyl Gel (India)
Gel; Topical; Diclofenac Diethylamine (Franco-Indian)
RELAXYL GEL Cream/ Gel/ Ointment / 1.16/ % / 30gm units (Franco-Indian)	$ 0.24
Relaxyl Gel 1.16%w/w GEL / 20g (Franco-Indian)	$ 0.33
Gel; Topical; Diclofenac Diethylamine 1.16% (Franco-Indian)
RELAXYL GEL topical gel 20g (Franco-Indian)	$ 0.52
Relaxyl Spray (India)
Relaxyl Spray Diclofenac diethylammonium1.16 % w/w, Lidocaine 2 % w/w, methyl salicylate 5 % w/w, linseed oil 3 % w/w, mephenesin 10 % w/w, menthol 5% w/w. SPY / 35g (Franco-Indian)	$ 0.70
RELAXYL SPRAY topical spray 35ml (Franco-Indian)	$ 0.70
Relaxyl SR
Tablet, Slow Release; Oral; Diclofenac Sodium
Tablet; Oral; Diclofenac Sodium
Relaxyl SR Diclofenac Sodium 100mg TAB / 10	$ 0.24
Tablets, Slow Release; Oral; Diclofenac Sodium
Tablets; Oral; Diclofenac Sodium
Relaxyl Tab (India)
Relaxyl Tab 50mg TAB / 10 (Franco-Indian)	$ 0.15
Relaxyl Tab 100mg SR-TAB / 10 (Franco-Indian)	$ 0.24
50 mg x 10's (Franco-Indian)	$ 0.15
100 mg x 10's (Franco-Indian)	$ 0.24
See 8886 substitutes for Reclofen

References

1. DailyMed. "DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "diclofenac". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "diclofenac". http://www.drugbank.ca/drugs/DB00586 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Reclofen are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Reclofen. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology