What is Ambrace?
Ambrace is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Ambrace is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.
Ambrace is also used to treat skin hives and itching in people with chronic skin reactions.
Ambrace may also be used for purposes not listed in this medication guide.
Ambrace indications
Treatment of seasonal allergic rhinitis, perennial rhinitis, urticaria, allergic dermatologic disorders, angioedema and conjunctivitis. Ambrace is generally considered to be ineffective in asthma.
Acute anaphylaxis should be treated with adrenaline; Ambrace and corticosteroids are given to prevent relapse.
Ambrace is also used to control the pruritus associated with skin disorders eg, atopic eczema.
How should I use Ambrace?
Use Ambrace orally disintegrating tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Ambrace orally disintegrating tablets by mouth with or without food.
- Be sure that your hands are completely dry before you handle Ambrace orally disintegrating tablets. Use the tablet right away after you remove it from the tablet blister.
- To open the tablet blister, peel back the foil, then gently remove the tablet. Place the tablet on the tongue. The tablet will dissolve quickly. You may take Ambrace orally disintegrating tablets with or without water.
- If you miss a dose of Ambrace orally disintegrating tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Ambrace orally disintegrating tablets.
Uses of Ambrace in details
This medication is an antihistamine that treats symptoms such as itching, runny nose, watery eyes, and sneezing from "hay fever" and other allergies. It is also used to relieve itching from hives.
Ambrace does not prevent hives or prevent/treat a serious allergic reaction (e.g., anaphylaxis). Therefore, if your doctor has prescribed epinephrine to treat allergic reactions, always carry your epinephrine injector with you. Do not use Ambrace in place of your epinephrine.
If you are self-treating with this medication, it is important to read the manufacturer's package instructions carefully so you know when to consult your doctor or pharmacist.
Do not use this medication in children younger than 6 years unless directed by the doctor. If you are using the chewable tablets, do not use in children younger than 2 years unless directed by your doctor.
How to use Ambrace
If you are using the over-the-counter product to self-treat, read all the directions on the product package before taking this medication. If your doctor has prescribed this medication, follow your doctor's directions and the instructions on your prescription label. If you have any questions, consult your doctor or pharmacist.
Take this medication by mouth with or without food, usually once a day or as directed by your doctor or the product package. If you are using the chewable tablets, chew each tablet well and swallow. Dosage is based on your age, condition, and response to treatment. Do not increase your dose or take this drug more often than directed. Do not take more of this medication than recommended for your age.
Tell your doctor if your allergy symptoms do not improve after 3 days of treatment or if your hives last more than 6 weeks. Seek immediate medical attention if your condition worsens or you think you have a serious medical problem (e.g., very serious allergic reaction/anaphylaxis).
Ambrace description
Ambrace competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. Ambrace's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease.
Ambrace dosage
Ambrace Dosage
Applies to the following strength(s): 10 mg; 5 mg/5 mL; 5 mg
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
- Allergic Rhinitis
- Urticaria
Usual Pediatric Dose for:
- Allergic Rhinitis
- Urticaria
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Dialysis
Usual Adult Dose for Allergic Rhinitis
10 mg orally once a day
Usual Adult Dose for Urticaria
10 mg orally once a day
Usual Pediatric Dose for Allergic Rhinitis
2 to 5 years: 5 mg orally once a day (syrup)
6 years or older: 10 mg orally once a day (tablets, capsule, and disintegrating tablets)
Usual Pediatric Dose for Urticaria
2 to 5 years: 5 mg orally once a day (syrup)
6 years or older: 10 mg orally once a day (tablets, capsule, and disintegrating tablets)
Renal Dose Adjustments
CrCl less than 30 mL/min: administer dosage every other day initially
Liver Dose Adjustments
Liver failure: administer dosage every other day initially
Dialysis
Ambrace is not significantly removed by hemodialysis, thus supplementary dosing is not required following hemodialysis.
More about Ambrace
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Espanol
- 43 Reviews - Add your own review/rating
Consumer resources
- Ambrace
- Ambrace capsules
- Ambrace chewable tablets
- Ambrace orally disintegrating tablets
- Ambrace syrup
- Other brands: Claritin, Alavert, Wal-itin, Claritin 24 Hour Allergy, More (7) »
Professional resources
- Ambrace (AHFS Monograph)
- More (4) »
Related treatment guides
- Allergic Rhinitis
- Urticaria
Ambrace interactions
See also:
What other drugs will affect Ambrace?
Ambrace (10 mg once daily) has been coadministered with therapeutic doses of erythromycin, cimetidine, and ketoconazole in controlled clinical pharmacology studies in adult volunteers. Although increased plasma concentrations (AUC 0-24 hrs) of Ambrace and/or descarboethoxyloratadine were observed following coadministration of Ambrace with each of these drugs in normal volunteers (n = 24 in each study), there were no clinically relevant changes in the safety profile of Ambrace, as assessed by electrocardiographic parameters, clinical laboratory tests, vital signs, and adverse events. There were no significant effects on QTc intervals, and no reports of sedation or syncope. No effects on plasma concentrations of cimetidine or ketoconazole were observed. Plasma concentrations (AUC 0-24 hrs) of erythromycin decreased 15% with coadministration of Ambrace relative to that observed with erythromycin alone. The clinical relevance of this difference is unknown. These above findings are summarized in TABLE 1.
TABLE 1 Effects on Plasma Concentrations (AUC 0-24 hrs) of Ambrace and Descarboethoxyloratadine After 10 Days of Coadministration (Ambrace 10 mg) in Normal Volunteers | ||
Ambrace | Descarboethoxyloratadine | |
---|---|---|
Erythromycin (500 mg q8h) | + 40% | +46% |
Cimetidine (300 mg qid) | +103% | + 6% |
Ketoconazole (200 mg q12h) | +307% | +73% |
Ambrace side effects
See also:
What are the possible side effects of Ambrace?
Applies to Ambrace: oral fixed-combination tablets, oral orally disintegrating tablets, oral solution, oral tablets
Side effects include:
Children 2–5 years of age receiving oral solution: Diarrhea, epistaxis, pharyngitis, flu-like symptoms, fatigue, stomatitis, tooth disorder, earache, viral infection, rash.
Children 6–12 years of age receiving oral solution: Nervousness, wheezing, fatigue, hyperkinesia, abdominal pain, conjunctivitis, dysphonia, upper respiratory tract infection.
Adults and children ≥12 years of age receiving conventional or orally disintegrating tablets: Headache, somnolence, fatigue, dry mouth.
Fixed combination Ambrace (the active ingredient contained in Ambrace Reditab) pseudoephedrine sulfate preparations: Insomnia, dry mouth, headache, somnolence, nervousness, dizziness, fatigue.
Ambrace contraindications
See also:
What is the most important information I should know about Ambrace?
Do NOT use Ambrace if:
you are allergic to any ingredient in Ambrace
Contact your doctor or health care provider right away if any of these apply to you.
Active ingredient matches for Ambrace:
Loratadine in Hong Kong.
List of Ambrace substitutes (brand and generic names) | Sort by popularity |
Unit description / dosage (Manufacturer) | Price, USD |
Ambica Loratadine (Philippines) | |
Ambica Loratadine 10 mg x 20's | |
Amcal Loratadine (Australia) | |
Analor (Bangladesh) | |
Anhissen (Indonesia) | |
Anlos (Indonesia) | |
Antal (Philippines) | |
Anti-Sneeze (Pakistan) | |
Antial (Pakistan) | |
Antil (Ecuador) | |
Antilergal (Mexico) | |
Antimin (Pakistan, Taiwan) | |
Antimin / CCPC 5 mL | |
Antimin / CCPC 20 mL | |
Antimin 0.4 mg/1 mL x 1 mL | |
Antimin 0.4 mg/1 mL x 60 mL | |
Antimin 0.4 mg/1 mL x 120 mL | |
Ao Hui Feng (China) | |
Ao Mi Xin (China) | |
Ao Shu (China) | |
AP-Loratadine (South Africa) | |
APC-Loratadine (Canada) | |
Apex-Loratadine (South Africa) | |
Apo-Loratadine (Canada, Hong Kong, Malaysia, New Zealand) | |
Tablet; Oral; Loratadine 10 mg | |
Apo-Loratadine / strip 10 mg x 20's | |
Apo-Loratadine / strip 10 mg x 600's | |
Apo-Loratadine / bottle 10 mg x 100's | |
Apo-Loratadine 10 mg x 10 x 18's | |
Apo-loratadine tablet 10 mg (Apotex Inc (Canada)) | |
Apothecare Loratadine (Lebanon) | |
Arclenxyl (Vietnam) | |
Arclenxyl 10 mg x 1 Bottle 300 Tablet | |
Ardin (Singapore) | |
Ardin 10 mg x 100 Tablet (Korea Pharm) | |
Ardin 10 mg x 50 x 10's (Korea Pharm) | |
Ardin tab 10 mg 50 x 10's (Korea Pharm) | |
ARDIN syr 200ml (Korea Pharm) | $ 0.90 |
Aridine (Thailand) | |
Aridine 10 mg x 500's | |
Aridine 10 mg x 10 x 10's | |
Aridine 5 mg x 60 mL | |
Aridine 5 mg x 960 mL | |
ASOLOR | |
ASOLOR 10 MG TABLET 1 strip / 10 tablets each (Asolear Pharma Pvt Ltd) | $ 0.80 |
Asolor 10mg Tablet (Asolear Pharma Pvt Ltd) | $ 0.08 |
Astena (Philippines) | |
Astol (Colombia) | |
Atinac (Brazil) | |
See 1852 substitutes for Ambrace |
References
- DailyMed. "LORATADINE; PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "loratadine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "loratadine". http://www.drugbank.ca/drugs/DB00455 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Ambrace are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Ambrace. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported useful
Was the Ambrace drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users | % | ||
---|---|---|---|
Useful | 1 | 100.0% |
Consumer reported price estimates
No survey data has been collected yet1 consumer reported time for results
To what extent do I have to use Ambrace before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 1 week and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Ambrace. To get the time effectiveness of using Ambrace drug by other patients, please click here.
Users | % | ||
---|---|---|---|
1 week | 1 | 100.0% |
1 consumer reported age
Users | % | ||
---|---|---|---|
30-45 | 1 | 100.0% |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology