Bromoxy indications
Bromoxy hydrochloride SYRUP indicated for cough associated with wheeziness (bronchospasm) and tenacious phlegm (sputum).
Uses of Bromoxy in details
Bromoxy is used to treat breathing difficulties caused by excessive mucus secretions in the air passages associated with respiratory tract infections.
Bromoxy description
Each tablet also contains lactose, maize or potato starch, gelatine and magnesium stearate as excipients.
The oral/inhalation solution also contains tartaric acid and methyl parahydroxybenzoate as excipients.
The syrup also contains tartaric acid, benzoic acid, sodium carboxymethylcellulose, glycerol, sorbitol solution, pharma flavor and ethanol as excipients.
Each capsule also contains lactose, cornstarch and magnesium stearate as excipients.
Bromoxy HCl is N-cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)amine hydrochloride.
Bromoxy dosage
Unless otherwise prescribed, the following doses are recommended:
Tablet: Adults and Children >12 years: 8 mg (1 tab) thrice daily; 6-12 years: 4 mg (½ tab) thrice daily; 2-6 years: 4 mg (½ tab) twice daily.
Oral Solution:
Adults and Children >12 years: 4 mL thrice daily; 6-12 years: 2 mL thrice daily; 2-6 years: 20 drops thrice daily; <2 years: 10 drops thrice daily.Inhalation Solution (with aerosol apparatus): It is generally recommended to warm inhalation solution to body temperature before inhalation. Patients with bronchial asthma may be advised to commencing inhalation after they have taken their regular bronchospasmolytic therapy.
Adults: 4 mL. Children >12 years: 2 mL; 6-12 years: 1 mL; 2-6 years: 10 drops; <2 years: 5 drops. All doses to be taken twice daily.
The solution may be diluted 1:1 in physiological saline solution. In order to avoid precipitation, the solution should be inhaled immediately after mixing. The combined administration of inhalation and oral application intensifies the effect, and is especially suited for the commencement of treatment in cases where the full effect is to be reached quickly.
Syrup: Adults and Children >12 years: 5 ml (1 tsp) thrice daily.
At commencement of treatment, it may be necessary to increase the total daily dose up to 48 mg in adults.
The syrup is sugar-free and therefore suitable for diabetics and small children.
Ampoule: Severe cases, before and after surgical intervention: 1 amp SC, IM or IV (duration of injection: 2-3 min) 2-3 times daily.
Capsule: Adults: 1 cap 3 times daily.
It is recommended for the initial phase of treatment usually lasting not more than a week.
Patients being treated with Bromoxy should be notified of an expected increase in the flow of secretions.
Bromoxy interactions
A reduction in dose of cardiac glycosides (e.g. digitalis) and quinidine might become necessary in patients suffering from congestive cardiac failure because of the positive inotropic effect of orciprenaline sulphate.
Bromoxy hydrochloride SYRUP should not be administered concomitantly with beta-blocking agents, due to orciprenaline’s reversal of anti-hypertensive action.
The concomitant use of other sympathomimetic agents should be carefully controlled to avoid potentiation of effects.
Bromoxy side effects
Bromoxy’s pharmacological action may lead to gastric irritation. A transient rise in serum aminotransferase values have been reported due to Bromoxy.
Orciprenaline sulphate, as a sympathomimetic agent, may precipitate a wide range of adverse effects. Side-effects include fear; anxiety, restlessness, tremor, insomnia, confusion, irritability, weakness and psychotic states. Appetite may be reduced and nausea and vomiting may occur. A rise in blood pressure which may produce cerebral haemorrhage and pulmonary oedema, tachycardia and cardiac arrhythmias, anginal pain, palpitations, and cardiac arrest. Hypotension with dizziness and fainting and flushing may occur. Other effects that may occur include difficulty in micturition and urinary retention; dyspnoea; weakness; headache; disturbances of glucose metabolism; sweating and hypersalivation. Muscle cramps or twitching or unpleasant taste may occur.
Bromoxy contraindications
Bromoxy hydrochloride SYRUP is contra-indicated in patients with known hypersensitivity to sympathomimetic amines or any of the other ingredients; hypertrophic obstructive cardiomyopathy; and tachyarrhythmia.
Sympathomimetics, such as orciprenaline sulphate, may interact with monoamine oxidase inhibitors (MAOI), and therefore Bromoxy hydrochloride SYRUP should not be given to patients receiving such treatment or within 14 days of MAOI treatment termination.
Safety in pregnancy and lactation has not been established.
Active ingredient matches for Bromoxy:
| Unit description / dosage (Manufacturer) | Price, USD |
| Bromoxy 250+8 Tablet | $ 0.05 |
List of Bromoxy substitutes (brand and generic names): | |
| Bromox (Venezuela) | |
| Bromox 500mg Capsule (Mamta Pharmaceuticals) | $ 0.07 |
| Bromoxykan | |
| Bromoxykan 250+8 Tablet (Kansas Laboratories Pvt. Ltd.) | $ 0.04 |
| Bromoxyl KT | |
| Bromoxyl KT 125+4 Tablet (Concept Pharmaceuticals Ltd.) | $ 0.03 |
| Bromso (Thailand) | |
| Bromso 8 mg x 1, 000's (T. O. Chemicals) | |
| Bromso 4 mg/5 mL x 60 mL (T. O. Chemicals) | |
| Bromso elixir 4 mg/5 mL 60 mL x 1's (T. O. Chemicals) | |
| Bromso tab 8 mg 1000's (T. O. Chemicals) | |
| Bromxin (Myanmar) | |
| Bromxine (Hong Kong, Malaysia, Singapore, Thailand) | |
| Bromxine 8 mg x 1, 000's (General Drugs House) | |
| Bromxine 8 mg x 1000's (General Drugs House) | |
| Bromxine 4 mg/5 mL x 60 mL x 1's (General Drugs House) | |
| Bromxine tab 8 mg 1000's (General Drugs House) | |
| Bromxine Atlantic (Thailand) | |
| Bromxine Atlantic 8 mg x 1, 000's (Atlantic Lab) | |
| Bromxine Atlantic tab 8 mg 1000's (Atlantic Lab) | |
| Bron-Hal (Greece) | |
| Bronacim (Venezuela) | |
| Bronair (Ecuador) | |
| Bronchi Mereprine (Belgium) | |
| Bronchi-Mereprine (Belgium) | |
| Broncho Solvin | |
| Broncho Solvin 100+8+2.5 Tablet (IPCA Laboratories Ltd.) | $ 0.02 |
| Bronchodian | |
| Bronchodian 100 ml Syrup (Meri Odin Life Sciences) | $ 0.02 |
| Bronchofit (India) | |
| Bronchofit 100 ml Suspension (Pharmatech Healthcare) | $ 0.04 |
| Bronchofit 60 ml Suspension (Pharmatech Healthcare) | $ 0.05 |
| BRONCHOFIT syr 100ml (Pharmatech Healthcare) | $ 0.54 |
| BRONCHOFIT syr 60ml (Pharmatech Healthcare) | $ 0.39 |
| Bronchohexin 8mg voor honden en katten (Netherlands) | |
| Broncholik | |
| Broncholik 100 ml Syrup (SPS Medipol Pvt. Ltd.) | $ 0.03 |
| Bronchosan (Czech Republic, Slovakia) | |
| Drops; Oral; Anise Oil 0.25 mg; Bromhexine Hydrochloride 8 mg; Eucalyptus Oil 0.25 mg; Fennel Oil 0.75 mg; Menthol 1.5 mg; Origanum Oil 0.25 mg; Peppermint Oil 0.25 mg / g (Vitasan) | |
| Bronchosan 25 ml - 1 Drops (Vitasan) | $ 10.40 |
| Bronchosol-BR | |
| Bronchosol-BR 2+8 Tablet (Tosc International Pvt Ltd.) | $ 0.01 |
| Bronchotussine (Greece, Malta) | |
| Bronclear (Pakistan, Thailand) | |
| Bronclear 8 mg x 1, 000's (Polipharm) | |
| Bronco Magimox (Peru) | |
| Broncobiot (Peru) | |
| Broncocalmine (Argentina) | |
| Broncocalmine Oriental (Argentina) | |
| Broncoff | |
| Broncoff 60 ml Syrup (Kylsans Laboratories Ltd) | $ 0.04 |
| Broncogard | |
| Broncogard 100 ml Syrup (Nimbles Biotech Pvt Ltd) | $ 0.05 |
| Broncokin (Italy) | |
| Broncomet (Bangladesh) | |
| Broncophar Pediátrico (Peru) | |
| Broncosolvan (Uruguay) | |
See 1877 substitutes for Bromoxy | |
References
- PubChem. "bromhexine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Bromhexine". http://www.drugbank.ca/drugs/DB09019 (accessed September 17, 2018).
- MeSH. "Expectorants". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
