Kofril indications
Kofril Injection, USP, after dilution in isotonic sodium chloride injection, may be indicated in the treatment of patients with (1) hypochloremic states and (2) metabolic alkalosis.
Uses of Kofril in details
Kofril is used for the relief of cough in the form of cough expectorant. It is also used as an injection to treat patients with hypochloremia and metabolic alkalosis.
Kofril dosage
Kofril Injection, USP is administered intravenously and must be diluted before use. Solutions for intravenous infusion should not exceed a concentration of 1% to 2% of Kofril.
Dosage is dependent upon the condition and tolerance of the patient. It is recommended that the contents of one to two vials (100 to 200 mEq) be added to 500 or 1000 mL of isotonic (0.9%) sodium chloride injection. The rate of intravenous infusion should not exceed 5 mL per minute in adults (approximately 3 hours for infusion of 1000 mL). Dosage should be monitored by repeated serum bicarbonate determinations.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.
Kofril interactions
In a treatment, patients should be monitored closely for signs of ammonia poisoning: pallor, sweating, irregular breathing, vomiting, bradycardia, arrhythmias, tremors, convulsions and coma.
Kofril should be used with caution in patients with heart and lung failure.
A longer-term correction of a hypochloraemia in patients with secondary metabolic alkalosis due to an intracellular potassium depletion can not be achieved by the sole administration of Kofril. Concomitant administration of potassium is also necessary.
Kofril side effects
See also:
What are the possible side effects of Kofril?
Rapid intravenous administration of Kofril may be accompanied by pain or irritation at the site of injection or along the venous route.
Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia (from large volume diluent).
If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.
Kofril contraindications
Kofril is contraindicated in patients with severe impairment of renal or hepatic function.
Kofril should not be administered when metabolic alkalosis due to vomiting of hydrochloric acid is accompanied by loss of sodium (excretion of sodium bicarbonate in the urine).
Active ingredient matches for Kofril:
| Unit description / dosage (Manufacturer) | Price, USD |
| Kofril 100 ml Expectorant | $ 0.01 |
List of Kofril substitutes (brand and generic names): | |
| Kof-Kontrol (Australia) | |
| Kufex | |
| Kufex 100 ml Syrup (Lloyds Pharmaceuticals) | $ 0.01 |
| Kumaphyl | |
| Kumaphyl 100 ml Syrup (Kumayun Drugs Private Limted) | $ 0.01 |
| Nomkof B NF | |
| Nomkof B NF 100 ml Syrup (Cadila Healthcare (Zydus Cadila Healthcare Ltd)) | $ 0.02 |
| Nomkof B NF 60 ml Syrup (Cadila Healthcare (Zydus Cadila Healthcare Ltd)) | $ 0.02 |
| Nomkof Exp (India) | |
| Nomkof Exp 100 ml Expectorant (Cadila Healthcare (Zydus Cadila Healthcare Ltd)) | $ 0.02 |
| NOMKOF EXP syr 100ml (Cadila Healthcare (Zydus Cadila Healthcare Ltd)) | $ 0.30 |
| Nospin Paediatric | |
| Nospin Paediatric 50 ml Suspension (Brussels Laboratories Pvt. Ltd.) | $ 0.03 |
| Nyal Bronchitis (Australia) | |
| Nyal Bronchitis Cough Medicine (Australia) | |
| Oricof | |
| Oricof 100 ml Syrup (Orison Pharmaceuticals) | $ 0.02 |
| Oril Expectorant | |
| Oril Expectorant 110 ml Expectorant (Optho Remedies Pvt.Ltd.) | $ 0.01 |
| Osodryl | |
| Osodryl 100 ml Syrup (Osho Pharma Pvt.Ltd.) | $ 0.02 |
| Oyiskof G | |
| Oyiskof G 100 ml Syrup (Oyster Labs Limited) | $ 0.02 |
| PD-LYTE-G (India) | |
| 500ml (Parenteral Drugs) | $ 0.40 |
| PD-LYTE-G infusion 500ml (Parenteral Drugs) | $ 0.40 |
| Pottie's Cough Mixture (Australia) | |
| PV Tussin Syrup | |
| Quino Plasmol Strong Syrup | |
| Quino Plasmol Strong Syrup (Universal Drug House Pvt Ltd) | $ 0.03 |
| Sal Ammoniac | |
| Salammonite | |
| Salmiac | |
| Sardryl | |
| Sardryl 100 ml Syrup (Saar Biotech) | $ 0.02 |
| Sardryl 60 ml Syrup (Saar Biotech) | $ 0.03 |
| Scordryl | |
| Scordryl 100 ml Syrup (Scortis Labs (P) Ltd) | $ 0.02 |
| Silvina DB | |
| Silvina DB 100 ml Syrup (Silicon Pharma (Rhombus Pharma Pvt Ltd)) | $ 0.06 |
| Siokof P | |
| Siokof P 60 ml Syrup (Albert David Limited) | $ 0.02 |
| Siokof P Syrup (Albert David Limited) | $ 0.28 |
| Soventol Exp. | |
| Soventol Exp. 100 ml Expectorant (Nicholas Piramal India Ltd.) | $ 0.02 |
| Sputes Expectorant | |
| Sputes Expectorant 100 ml Expectorant (Agron Remedies Pvt Ltd) | $ 0.02 |
| Sudex Exp (India) | |
| Sudex Exp 100 ml Expectorant (Comed Chemicals Pvt Ltd) | $ 0.01 |
| Sudex Exp 100 ml Eastern Drugs Expectorant (Comed Chemicals Pvt Ltd) | $ 0.02 |
| Sudex Exp 50 ml Expectorant (Comed Chemicals Pvt Ltd) | $ 0.01 |
| SUDEX EXP syr 100ml (Comed Chemicals Pvt Ltd) | $ 0.20 |
| SUDEX EXP syr 50ml (Comed Chemicals Pvt Ltd) | $ 0.13 |
| Syncof | |
| Syncof 100 ml Syrup (Smilax Pharmaceuticals) | $ 0.02 |
| Syncof 50 ml Syrup (Smilax Pharmaceuticals) | $ 0.02 |
| Tri Cough | |
| Tri Cough 100 ml Syrup (Maitri Healthcare Pvt. Ltd.) | $ 0.00 |
| Tricos | |
| Tricos 100 ml Syrup (Atlantic Pharmaceuticals) | $ 0.03 |
| Tripex | |
| Tripex 100 ml Syrup (Modgal Pharmaceuticals (P) Ltd.) | $ 0.03 |
| Trodryl | |
| Trodryl 100 ml Syrup (Divine Pharma) | $ 0.03 |
| Tussoric Cough | |
| Tussoric Cough 100 ml Syrup (Euphoric Pharmaceuticals Pvt.Ltd.) | $ 0.02 |
See 152 substitutes for Kofril | |
References
- DailyMed. "AMMONIUM CHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "AMMONIUM CHLORIDE". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "ammonium". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
