• Lincopat indications
• Uses of Lincopat in details
• Lincopat description
• Lincopat dosage
• Lincopat interactions
• Lincopat side effects
• Lincopat contraindications

What is Lincopat?

Lincopat is an antibiotic that fights bacteria.

Lincopat is used to treat severe bacterial infections in people who cannot use penicillin antibiotics.

Lincopat is used only for a severe infection. This medicine will not treat a viral infection such as the common cold or flu.

Lincopat may also be used for purposes not listed in this medication guide.

Lincopat indications

Lincopat Sterile Solution is indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci. Its use should be reserved for penicillin-allergic patients or other patients for whom, in the judgment of the physician, a penicillin is inappropriate. Because of the risk of antibiotic-associated pseudomembranous colitis, as described in Warnings, before selecting Lincopat the physician should consider the nature of the infection and the suitability of less toxic alternatives (e.g., erythromycin).

Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to Lincopat.

Indicated surgical procedures should be performed in conjunction with antibiotic therapy.

Lincopat has been demonstrated to be effective in the treatment of staphylococcal infections resistant to other antibiotics and susceptible to Lincopat. Staphylococcal strains resistant to Lincopat have been recovered; culture and susceptibility studies should be done in conjunction with therapy with Lincopat. In the case of macrolides, partial but not complete cross-resistance may occur. The drug may be administered concomitantly with other antimicrobial agents when indicated.

Lincopat is not indicated in the treatment of minor bacterial infections or viral infections.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Lincopat and other antibacterial drugs, Lincopat should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

How should I use Lincopat?

Use Lincopat as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Lincopat is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
• If you miss a dose of Lincopat, call your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use Lincopat.

Uses of Lincopat in details

Lincopat is used in treatment of bacterial infections.

Lincopat description

Each mL of Lincopat Sterile Solution contains Lincomycin hydrochloride equivalent to Lincopat 300 mg.

Lincopat sterile solution contains Lincomycin hydrochloride which is the monohydrated salt of Lincopat, a substance produced by the growth of a member of the lincolnensis group of Streptomyces lincolnensis (Fam. Streptomycetaceae).

The chemical name for Lincopat hydrochloride is Methyl 6, 8-dideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrolidinecarboxamido)-1-thio-D-erythro-α-D-galacto-octopyranoside monohydrochloride monohydrate. Its molecular formula is C₁₈H₃₄N₂O₆S.HCl. H₂O and the molecular weight is 461.01.

Lincopat hydrochloride is a white or practically white, crystalline powder and is odorless or has a faint odor. Its solutions are acid and are dextrorotatory. Lincopat hydrochloride is freely soluble in water; soluble in dimethylformamide and very slightly soluble in acetone.

Excipients/Inactive Ingredients: Benzyl alcohol 9.45 mg added as preservative.

Lincopat dosage

Lincopat Dosage

Generic name: Lincopat HYDROCHLORIDE 300mg in 1mL

Dosage form: injection, solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

If significant diarrhea occurs during therapy, this antibacterial should be discontinued.

INTRAMUSCULAR

Adults

Serious infections—600 mg (2 mL) intramuscularly every 24 hours. More severe infections—600 mg (2 mL) intramuscularly every 12 hours or more often.

Pediatric patients over 1 month of age

Serious infections—one intramuscular injection of 10 mg/kg (5 mg/lb) every 24 hours. More severe infections—one intramuscular injection of 10 mg/kg (5 mg/lb) every 12 hours or more often.

INTRAVENOUS

Adults

The intravenous dose will be determined by the severity of the infection. For serious infections doses of 600 mg of Lincopat (2 mL of Lincopat) to 1 gram are given every 8 to 12 hours. For more severe infections these doses may have to be increased. In life-threatening situations daily intravenous doses of as much as 8 grams have been given.

Intravenous doses are given on the basis of 1 gram of Lincopat diluted in not less than 100 mL of appropriate solution and infused over a period of not less than one hour.

Dose	Vol. Diluent	Time
600 mg	100 mL	1 hr
1 gram	100 mL	1 hr
2 grams	200 mL	2 hr
3 grams	300 mL	3 hr
4 grams	400 mL	4 hr

These doses may be repeated as often as required to the limit of the maximum recommended daily dose of 8 grams of Lincopat.

Pediatric patients over 1 month of age

10 to 20 mg/kg/day (5 to 10 mg/lb/day) depending on the severity of the infection may be infused in divided doses as described above for adults.

NOTE: Severe cardiopulmonary reactions have occurred when this drug has been given at greater than the recommended concentration and rate.

SUBCONJUNCTIVAL INJECTION

0.25 mL (75 mg) injected subconjunctivally will result in ocular fluid levels of antibacterial (lasting for at least 5 hours) with MICs sufficient for most susceptible pathogens.

Patients with diminished renal function

When therapy with Lincopat is required in individuals with severe impairment of renal function, an appropriate dose is 25 to 30% of that recommended for patients with normally functioning kidneys.

More about Lincopat (Lincopat)

• Side Effects
• During Pregnancy
• Dosage Information
• Drug Interactions
• Support Group
• En Espanol
• 1 Review - Add your own review/rating
• Generic Availability

Consumer resources

• Lincopat
• Lincopat (Advanced Reading)

Professional resources

• Lincopat (AHFS Monograph)
• Lincopat (FDA)

Related treatment guides

• Bacterial Infection
• Conjunctivitis, Bacterial

Lincopat interactions

See also:
What other drugs will affect Lincopat?

BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Avoid combination

BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Monitor therapy

Cholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Avoid combination

Doxofylline: Lincopat may increase the serum concentration of Doxofylline. Monitor therapy

Erythromycin (Systemic): May diminish the therapeutic effect of Lincopat. Avoid combination

Kaolin: May decrease the absorption of Lincosamide Antibiotics. Monitor therapy

Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Monitor therapy

Mecamylamine: Lincosamide Antibiotics may enhance the neuromuscular-blocking effect of Mecamylamine. Avoid combination

Neuromuscular-Blocking Agents: Lincosamide Antibiotics may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Monitor therapy

Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Consider therapy modification

Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected. Management: Vaccination with live attenuated typhoid vaccine (Ty21a) should be avoided in patients being treated with systemic antibacterial agents. Use of this vaccine should be postponed until at least 3 days after cessation of antibacterial agents. Consider therapy modification

Lincopat side effects

See also:
What are the possible side effects of Lincopat?

Applies to Lincopat: capsule, solution

In addition to its needed effects, some unwanted effects may be caused by Lincopat (the active ingredient contained in Lincopat). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Lincopat:

More common:

• Abdominal or stomach cramps and pain (severe)
• abdominal tenderness
• diarrhea (watery and severe), which may also be bloody
• fever

Less common:

• Skin rash, redness, and itching
• sore throat and fever
• unusual bleeding and bruising

Note: Some of the above side effects may also occur up to several weeks after you Stop taking Lincopat.

Minor Side Effects

Some of the side effects that can occur with Lincopat may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

• Diarrhea (mild)
• nausea and vomiting
• stomach pain

Less common:

• Itching of rectal or genital (sex organ) areas

Lincopat contraindications

See also:
What is the most important information I should know about Lincopat?

Before receiving Lincopat, tell your doctor if you have asthma or allergies, a stomach or intestinal disorder such as colitis, liver or kidney disease, or epilepsy or other seizure disorder.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Serious side effects of Lincopat include fever, chills, body aches, flu symptoms, white patches or sores inside your mouth or on your lips, severe blistering or peeling skin rash, feeling like you might pass out, easy bruising or bleeding, unusual weakness, or urinating less than usual or not at all.

Active ingredient matches for Lincopat:

Lincomycin in Mexico.

List of Lincopat substitutes (brand and generic names)	Sort by popularity
Unit description / dosage (Manufacturer)	Price, USD
Lincono (Thailand)
Lincono 300 mg/1 mL x 10 mL x 10's (Milano)
Lincophar (Indonesia)
Lincophar 500 mg x 60's (Pharos)	$ 37.24
Lincopharm (Australia)
Lincopharm 800 (Australia)
Lincopi (Vietnam)
Lincopi 600 mg/2 mL x 10 tube 2 mL
Lincoplax (Brazil)
Lincople (Vietnam)
Lincople 600 mg/2 mL x 10 Bottle
Lincoplus (Peru)
Lincorex
Lincosa (Malaysia)
Lincosa 300 mg/1 mL x 10 mL x 1's (ZHPL (Sayona))
300 mg x 1ml (ZHPL (Sayona))	$ 0.11
Lincosa 300mg AMP / 1ml (ZHPL (Sayona))	$ 0.11
LINCOSA inj 300 mg x 1ml (ZHPL (Sayona))	$ 0.11
Lincosa 300 mg inj 2 mL x 50 x 1's (ZHPL (Sayona))
Lincosa 300 mg inj 10 mL x 10 x 1's (ZHPL (Sayona))
Lincosan (Yemen)
LINCOSCAN 400mg/g dla swin i kurczat For pigs and chickens (Poland)
Lincosol (United States)
Lincostad (Vietnam)
Lincostad 500 mg x 10 Blister x 10 Tablet
Lincotax (Brazil)
Lincotec (Italy)
Lincotic (Pakistan)
Lincotin (Pakistan)
Lincovax (Brazil)
Lincover (Mexico)
LINCOWOCK
LINCOWOCK 1MG INJECTION 1 vial / 1 ML injection each (Wockhardt Ltd)	$ 0.09
LINCOWOCK 2MG INJECTION 1 vial / 2 ML injection each (Wockhardt Ltd)	$ 0.16
Lincowock 2mg Injection (Wockhardt Ltd)	$ 0.08
Lincozaf (Pakistan)
Lincozin (India)
Lincozin 250mg CAP / 10 (Taj Pharma)	$ 0.70
Lincozin 500mg CAP / 10 (Taj Pharma)	$ 1.12
Lincozin 125mg/mL SYR / 60ml (Taj Pharma)	$ 0.55
Lincozin 300mg/mL INJ / 1ml (Taj Pharma)	$ 0.13
Lincozin 300mg/mL INJ / 2ml (Taj Pharma)	$ 0.22
250 mg x 10's (Taj Pharma)	$ 0.70
500 mg x 10's (Taj Pharma)	$ 1.12
125 mg x 1 mL x 60ml (Taj Pharma)	$ 0.55
300 mg x 1 mL x 1ml (Taj Pharma)	$ 0.13
300 mg x 1 mL x 2ml (Taj Pharma)	$ 0.22
LINCOZIN cap 250 mg x 10's (Taj Pharma)	$ 0.70
LINCOZIN cap 500 mg x 10's (Taj Pharma)	$ 1.12
LINCOZIN syr 125 mg x 1 mL x 60ml (Taj Pharma)	$ 0.55
See 520 substitutes for Lincopat

References

1. PubChem. "lincomycin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
2. DrugBank. "lincomycin". http://www.drugbank.ca/drugs/DB01627 (accessed September 17, 2018).
3. MeSH. "Protein Synthesis Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Lincopat are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lincopat. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

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Information checked by Dr. Sachin Kumar, MD Pharmacology