Nt-KUF-AM indications
For use Max Pidek Pharmaceuticals as monotherapy and in combination with clavulanic acid: an infectious-inflammatory diseases caused by susceptible microorganisms, including bronchitis, pneumonia, tonsillitis, pyelonephritis, urethritis, infections of the gastrointestinal tract, gynecological infections, infections of the skin and soft tissue, listeria, leptospirosis, gonorrhea.
For use Max Pidek Pharmaceuticals in combination with metronidazole: chronic gastritis in acute, peptic ulcer and duodenal ulcer in acute, associated with Helicobacter Pylori.
Uses of Nt-KUF-AM in details
Nt-KUF-AM is used to treat certain diseases of the respiratory tract and to relieve cough associated with thickened mucous.
Nt-KUF-AM description
Each retard capsule contains Ambroxol hydrochloride 75 mg.
Each tablet contains Ambroxol hydrochloride 30 mg.
Each 5 mL of syrup contains Ambroxol hydrochloride 15 or 30 mg.
Each mL of syrup (infant drops) contains Ambroxol hydrochloride 6 mg.
Nt-KUF-AM hydrochloride is trans-4-[(2-amino-3,5-dibromo-benzyl)amino] cyclohexanol hydrochloride.
It also contains the following excipients: Retard Capsules: Crospovidone collidon CL, carnauba wax, stearyl alcohol, magnesium stearate.
Tablets: Lactose, maize starch, colloidal silica, magnesium stearate.
Syrup: Purified water, sorbitol liquid, glycerol 85%, woodberry aroma (15 mg only), strawberry aroma (30 mg only), hydroxyethylcellulose, benzoic acid, acesulfame potassium, vanilla aroma.
Infant Drops: Hydroxyethylcellulose, sorbitol solution, glycerol 85%, sodium saccharin, pharma flavors, menthol, benzoic acid, propylene glycol.
Nt-KUF-AM dosage
Sustained-Release Capsule: Adults and Children >12 years: 1 cap once daily after meal with plenty of liquid (sufficient supply of liquid supports the expectorant effect of Nt-KUF-AM).
Nt-KUF-AM SR capsule is not suitable for children <12 years.
Tablet: Adults and Children >12 years: 1 tab thrice daily for the first 2-3 days and then 1 tab twice daily or ½ tab thrice daily. Children 6-12 years: ½ tab 2-3 times a day.
Syrup: Adults and Children >12 years: 10 mL thrice daily during the first 2-3 days, them 10 mL twice daily or 5 mL thrice daily. Children 6-12 years: 5 mL 2-3 times a day; 2-5 years: 2.5 mL 3 times a day; <2 years: 2.5 mL 2 times a day.
DS Syrup: Adults and Children >12 years: 5 mL thrice daily for 2-3 days then 5 mL twice daily for 2.5 mL thrice daily. Children 6-12 years: 2.5 mL 2-3 times a day.
Infant Drops: Children 13-24 months: 1.25 mL twice a day; 7-12 months: 1 mL twice a day; ≤6 months: 0.5 mL twice a day.
Nt-KUF-AM interactions
Amoxicillin may decrease the effectiveness of contraceptives for oral administration.
With the simultaneous use of Max Pidek Pharmaceuticals with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) appears synergies; with bacteriostatic antibiotic (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulphonamide) - antagonism.
Amoxicillin increases the effects of indirect anticoagulants inhibiting intestinal microflora, reduces the synthesis of vitamin K and prothrombin index.
Amoxicillin reduces the effect of drugs, in the process of metabolism that produce PABA.
Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs decrease the tubular secretion of amoxicillin, which can be accompanied by an increase in its concentration in blood plasma.
Antacids, glucosamine, laxatives, aminoglycosides, slow down and reduce, and ascorbic acid increases the absorption of amoxicillin.
With the combined use of amoxicillin and clavulanic acid pharmacokinetics of both components unchanged.
Nt-KUF-AM side effects
Allergic reactions: urticaria, erythema, edema Quincke, rhinitis, conjunctivitis, rarely - fever, joint pain, eosinophilia, in rare cases - anaphylactic shock.
Side effects associated with chemotherapy effect: possible development of super-infection (particularly in patients with chronic diseases or low resistance of the organism).
With prolonged use at high doses: dizziness, ataxia, confusion, depression, peripheral neuropathy, seizures.
Mostly when Max Pidek Pharmaceuticals used in combination with metronidazole: nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis; rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, a violation of hematopoiesis.
Mostly when Max Pidek Pharmaceuticals used in combination with clavulanic acid: cholestatic jaundice, hepatitis, rarely - erythema multiforme, toxic epidermal necrolysis, exfoliative dermatitis.
Nt-KUF-AM contraindications
Hypersensitivity to Nt-KUF-AM hydrochloride or to any other excipients of Nt-KUF-AM.
In case of rare hereditary conditions that may be incompatible with an excipient of Nt-KUF-AM, the use of Nt-KUF-AM is contraindicated.
Active ingredient matches for Nt-KUF-AM:
Ambroxol in India.
Ambroxol hydrochloride/guaiphenesin/menthol/terbutaline sulphate in India.
Unit description / dosage (Manufacturer) | Price, USD |
NT-KUF-AM Ambroxol hydrochloride 15 mg, Guaiphenesin 50 mg, Terbutaline sulphate 1.5 mg, Menthol 1 mg. SYR / 100ml | $ 0.58 |
100ml | $ 0.58 |
Nt-Kuf-Am Terbutaline sulphate 1.25 mg, Bromhexine hydrochloride 2 mg, Guaiphenesin 50 mg. SYR / 100ml | $ 0.54 |
NT-KUF-AM syr 100ml (Hauz) | $ 0.58 |
Nt-Kuf-Am Terbutaline sulphate 1.25 mg, Bromhexine hydrochloride 2 mg, Guaiphenesin 50 mg. SYR / 100ml | $ 0.54 |
List of Nt-KUF-AM substitutes (brand and generic names): | |
Nozik (India) | |
NOZIK syr 60ml (Candor (Aileron)) | |
Nucobrox (Thailand) | |
Nucobrox 30 mg x 500's (Bangkok Lab & Cosmetic) | |
Nucobrox 30 mg x 5 x 10 x 10's (Bangkok Lab & Cosmetic) | |
Nucobrox 30 mg/5 mL x 60 mL x 12's (Bangkok Lab & Cosmetic) | |
Nucobrox 30 mg/5 mL x 50's (Bangkok Lab & Cosmetic) | |
Nucobrox syr 30 mg/5 mL 50 x 1's (Bangkok Lab & Cosmetic) | |
Nucobrox syr 30 mg/5 mL 60 mL x 12 x 1's (Bangkok Lab & Cosmetic) | |
Nucobrox tab 30 mg 5 x 10 x 10's (Bangkok Lab & Cosmetic) | |
Nucobrox tab 30 mg 500's (Bangkok Lab & Cosmetic) | |
Nucope-AD (India) | |
Nucope-AD Desloratadine 5 mg, Pseudoephedrine 30 mg, Ambroxol 60 mg. FC-TAB / 10 (Mankind (Discovery)) | $ 0.28 |
10's (Mankind (Discovery)) | $ 0.28 |
NUCOPE-AD TABLET 1 strip / 10 tablets each (Mankind (Discovery)) | $ 0.53 |
NUCOPE-AD film-coated tab 10's (Mankind (Discovery)) | $ 0.28 |
Nufanibrox (Indonesia) | |
Nufanibrox 30 mg x 10 x 10's (Nufarindo) | $ 13.50 |
Nufanibrox 15 mg/5 mL x 60 mL x 1's (Nufarindo) | $ 2.46 |
Nuo Jian (China) | |
NUTROL N | |
NUTROL N TABLET 1 strip / 10 tablets each (Algen Healthcare Pvt Ltd) | $ 0.78 |
Nutuss-A (India) | |
Nutuss-A Ambroxol 15 mg, terbutalineSulphate 1.5 mg, Guaiphenesin50 mg. SYR / 100ml (Dr. Alson Labs) | $ 0.51 |
Nutuss-A Ambroxol 15 mg, terbutalineSulphate 1.5 mg, Guaiphenesin50 mg. SYR / 60ml (Dr. Alson Labs) | $ 0.31 |
100ml (Dr. Alson Labs) | $ 0.51 |
60ml (Dr. Alson Labs) | $ 0.31 |
NUTUSS-A syr 100ml (Dr. Alson Labs) | $ 0.51 |
NUTUSS-A syr 60ml (Dr. Alson Labs) | $ 0.31 |
Nymix Mucolytikum (Germany) | |
Olbenorm (Greece) | |
Onimex | |
Onimex 60 ml Syrup (Emcee Pharmaceuticals Pvt.Ltd.) | $ 0.03 |
Onimex 100 ml Syrup (Emcee Pharmaceuticals Pvt.Ltd.) | $ 0.02 |
ONIMEX 30MG/200MG EXPECTORANT 1 bottle / 100 ML expectorant each (Emcee Pharmaceuticals Pvt.Ltd.) | $ 0.71 |
Onimex Expectorant (Emcee Pharmaceuticals Pvt.Ltd.) | $ 0.01 |
Onimex Kid 15 mg/100 mg Syrup (Emcee Pharmaceuticals Pvt.Ltd.) | $ 0.57 |
Onimex SF 30 mg/200 mg Syrup (Emcee Pharmaceuticals Pvt.Ltd.) | $ 0.95 |
Oox (India) | |
Oox Ambroxol 300mg, terbutaline1.25mg, guaiphenesin 5 EXP / 100ml (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.48 |
100ml (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.48 |
Oox 100 ml Expectorant (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.02 |
OOX 100MG/1.25MG/30MG SYRUP 1 bottle / 100 ML syrup each (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.55 |
OOX syr 100ml (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.65 |
Oox Syrup (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.55 |
Oox LC | |
Oox LC 60 ml Syrup (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.04 |
Oox LC 75+5 Tablet (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.05 |
OOX LC 5MG/30MG SYRUP 1 bottle / 60 ML syrup each (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.47 |
OOX LC 5MG/75MG TABLET 1 strip / 10 tablets each (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.48 |
Oox LC Syrup (St. Morrison (Aamorb Pharmaceuticals Pvt Ltd)) | $ 0.47 |
See 3598 substitutes for Nt-KUF-AM |
References
- DailyMed. "TERBUTALINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "terbutaline". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "ambroxol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology