Silin indications
Pernicious anemia, both uncomplicated and accompanied by nervous system involvement.
Dietary deficiency of Vitamin B12, occurring in strict vegetarians and in their breast-fed infants. (Isolated vitamin B12 deficiency is very rare).
Malabsorption of vitamin B12, resulting from structural or functional damage to the stomach, where intrinsic factor is secreted or to the ileum, where intrinsic factor facilitates vitamin B12 absorption. These conditions include tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than vitamin B12 deficiency.
Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces vitamin B12 deficiency.
Structural lesions leading to vitamin B12 deficiency include regional ileitis, ileal resections, malignancies, etc.
Competition for Vitamin B12 by intestinal parasites or bacteria.
The fish tapeworm (Diphyilobothrium latum) absorbs huge quantities of vitamin B12 and infested patients often have associated gastric atrophy. The blind-loop syndrome may produce deficiency of Vitamin B12 or folate.
Inadequate utilization of vitamin B12. This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.
For the Schilling Test.
Uses of Silin in details
Silin is a liver protectant and antioxidant. Treatment with Silin has shown slightly improved liver function, and showed improvement in patients with type 2 diabetes and diabetic nephropathy (kidney disease).
Silin description
Each 70-mg capsule contains Silin 70 mg (calculated as Silin) in dried extract of milk thistle fruits 86.5-93.3 mg while the 140-mg capsule contains Silin 140 mg (calculated as Silin) in dried extract of milk thistle fruits 173-186.6 mg.
Silin dosage
Unless otherwise directed by the physician: Adults and Children >12 years: Usual Dose: Initially, 1 cap 3 times daily.
Maintenance Dose: 1 cap 2 times daily.
Administration: Silin should be taken whole with some liquid before meals.
The physician should decide on the length of treatment.
Silin interactions
Fish lipid oil prevents blood clotting too quickly, therefore patients who are treated with anticoagulants must consult their doctor before taking Silin.
Silin side effects
Body as a Whole: Enlarged abdomen, asthenia, body odor, chest pain, chills, suicide, fever, generalized edema, fungal infection, malaise, neck pain, neoplasm, rheumatoid arthritis, and sudden death.
Cardiovascular System: Arrhythmia, bypass surgery, cardiac arrest, hyperlipemia, hypertension, migraine, myocardial infarct, myocardial ischemia, occlusion, peripheral vascular disorder, syncope, and tachycardia.
Digestive System: Anorexia, constipation, dry mouth, dysphagia, colitis, fecal incontinence, gastritis, gastroenteritis, gastrointestinal disorder, increased appetite, intestinal obstruction, melena, pancreatitis, tenesmus, and vomiting.
Hematologic-Lymphatic System: Lymphadenopathy.
Infections and Infestations: Viral infection.
Metabolic and Nutritional Disorders: Edema, hyperglycemia, increased ALT, and increased AST.
Musculoskeletal System: Arthralgia, arthritis, myalgia, pathological fracture, and tendon disorder.
Nervous System: Central nervous system neoplasia, depression, dizziness, emotional lability, facial paralysis, insomnia, vasodilatation, and vertigo.
Respiratory System: Asthma, bronchitis, increased cough, dyspnea, epistaxis, laryngitis, pharyngitis, pneumonia, rhinitis, and sinusitis.
Skin: Alopecia, eczema, pruritus, and sweating.
Special Senses: Cataract.
Urogenital System: Cervix disorder, endometrial carcinoma, epididymitis, and impotence.
Silin contraindications
Hypersensitivity to milk thistle fruits and/or other plants of the compositae, or to any of the excipients of Silin.
Active ingredient matches for Silin:
Silibinin in Taiwan.
| Unit description / dosage (Manufacturer) | Price, USD |
| Silin 100 mg | |
List of Silin substitutes (brand and generic names): | |
| Silimin (Taiwan) | |
| Silimin 150 mg x 1000's | |
| Silirin (Taiwan) | |
| Silirin 150 mg x 3 x 10's, 60's, 100 x 10's, 1000's | |
| SILIV (India) | |
| 70 mg x 10's (Finecure Pharmaceuticals Ltd) | |
| 140 mg x 10's (Finecure Pharmaceuticals Ltd) | |
| 35 mg x 5 mL x 100ml (Finecure Pharmaceuticals Ltd) | |
| Siliv 70mg TAB / 10 (Finecure Pharmaceuticals Ltd) | |
| Siliv 140mg TAB / 10 (Finecure Pharmaceuticals Ltd) | |
| Siliv 35mg x 5mL SUSP / 100ml (Finecure Pharmaceuticals Ltd) | |
| Siliv 140 mg Tablet (Finecure Pharmaceuticals Ltd) | $ 0.06 |
| Siliv 100 ml Suspension (Finecure Pharmaceuticals Ltd) | $ 0.03 |
| Siliv 70 mg Tablet (Finecure Pharmaceuticals Ltd) | $ 0.04 |
| SILIV tab 70 mg x 10's (Finecure Pharmaceuticals Ltd) | $ 0.41 |
| SILIV tab 140 mg x 10's (Finecure Pharmaceuticals Ltd) | $ 0.60 |
| SILIV oral susp 35 mg x 5 mL x 100ml (Finecure Pharmaceuticals Ltd) | $ 0.66 |
| Siliv 70mg TAB / 10 (Finecure Pharmaceuticals Ltd) | |
| Siliv 140mg TAB / 10 (Finecure Pharmaceuticals Ltd) | |
| Siliv 35mg x 5mL SUSP / 100ml (Finecure Pharmaceuticals Ltd) | |
| Silliver (Taiwan) | |
| Silliver 70 mg x 120's (Abbott) | |
| Silliver 70 mg x 500's (Abbott) | |
| Silmar (Colombia) | |
| Siluma (Taiwan) | |
| Siluma 70 mg | |
| Silvaysan (Germany) | |
| Capsule; Oral; Milk Thistle (Sanum-kehlbeck) | |
| Silybon (India) | |
| Silybon 70mg TAB / 10 (Micro Labs Ltd) | $ 0.70 |
| Silybon 140mg TAB / 10 (Micro Labs Ltd) | $ 0.94 |
| Silybon 35mg/5mL SUSP / 100ml (Micro Labs Ltd) | $ 1.04 |
| Silybon 35mg/5mL SUSP / 200ml (Micro Labs Ltd) | $ 1.81 |
| Silybon 200 ml Suspension (Micro Labs Ltd) | $ 0.05 |
| Silybon 140 mg Tablet (Micro Labs Ltd) | $ 0.11 |
| Silybon 100 ml Suspension (Micro Labs Ltd) | $ 0.06 |
| Silybon 70 mg Tablet (Micro Labs Ltd) | $ 0.08 |
| SILYBON 35 MG SUSPENSION 1 bottle / 100 ML suspension each (Micro Labs Ltd) | $ 1.54 |
| SILYBON 35 MG SUSPENSION 1 bottle / 200 ML suspension each (Micro Labs Ltd) | $ 2.71 |
| SILYBON 35 MG SUSPENSION 1 bottle / 60 ML suspension each (Micro Labs Ltd) | $ 1.54 |
| SILYBON 70 MG TABLET 1 strip / 10 tablets each (Micro Labs Ltd) | $ 1.05 |
| SILYBON film-coated tab 70 mg x 10's (Micro Labs Ltd) | $ 0.70 |
| SILYBON film-coated tab 140 mg x 10's (Micro Labs Ltd) | $ 0.94 |
| SILYBON oral susp 35 mg x 5 mL x 100ml (Micro Labs Ltd) | $ 1.20 |
| SILYBON oral susp 35 mg x 5 mL x 200ml (Micro Labs Ltd) | $ 1.81 |
| Silybon 35mg Suspension (Micro Labs Ltd) | $ 2.96 |
| Silybon 70mg Tablet (Micro Labs Ltd) | $ 0.11 |
| Silycon (Taiwan) | |
| Silycon 150 mg x 1000's | |
| Silygal (Czech Republic) | |
See 447 substitutes for Silin | |
References
- PubChem. "silibinin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Silibinin A". http://www.drugbank.ca/drugs/DB09298 (accessed September 17, 2018).
- DTP/NCI. "NSC651520: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Silin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Silin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported useful
Was the Silin drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
| Users | % | ||
|---|---|---|---|
| Useful | 1 | 100.0% | |
Consumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yet4 consumers reported age
| Users | % | ||
|---|---|---|---|
| 16-29 | 2 | 50.0% | |
| > 60 | 2 | 50.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
