Siluma indications
Pernicious anemia, both uncomplicated and accompanied by nervous system involvement.
Dietary deficiency of Vitamin B12, occurring in strict vegetarians and in their breast-fed infants. (Isolated vitamin B12 deficiency is very rare).
Malabsorption of vitamin B12, resulting from structural or functional damage to the stomach, where intrinsic factor is secreted or to the ileum, where intrinsic factor facilitates vitamin B12 absorption. These conditions include tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than vitamin B12 deficiency.
Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces vitamin B12 deficiency.
Structural lesions leading to vitamin B12 deficiency include regional ileitis, ileal resections, malignancies, etc.
Competition for Vitamin B12 by intestinal parasites or bacteria.
The fish tapeworm (Diphyilobothrium latum) absorbs huge quantities of vitamin B12 and infested patients often have associated gastric atrophy. The blind-loop syndrome may produce deficiency of Vitamin B12 or folate.
Inadequate utilization of vitamin B12. This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.
For the Schilling Test.
Uses of Siluma in details
Siluma is a liver protectant and antioxidant. Treatment with Siluma has shown slightly improved liver function, and showed improvement in patients with type 2 diabetes and diabetic nephropathy (kidney disease).
Siluma description
Each 70-mg capsule contains Siluma 70 mg (calculated as Siluma) in dried extract of milk thistle fruits 86.5-93.3 mg while the 140-mg capsule contains Siluma 140 mg (calculated as Siluma) in dried extract of milk thistle fruits 173-186.6 mg.
Siluma dosage
Unless otherwise directed by the physician: Adults and Children >12 years: Usual Dose: Initially, 1 cap 3 times daily.
Maintenance Dose: 1 cap 2 times daily.
Administration: Siluma should be taken whole with some liquid before meals.
The physician should decide on the length of treatment.
Siluma interactions
Fish lipid oil prevents blood clotting too quickly, therefore patients who are treated with anticoagulants must consult their doctor before taking Siluma.
Siluma side effects
Body as a Whole: Enlarged abdomen, asthenia, body odor, chest pain, chills, suicide, fever, generalized edema, fungal infection, malaise, neck pain, neoplasm, rheumatoid arthritis, and sudden death.
Cardiovascular System: Arrhythmia, bypass surgery, cardiac arrest, hyperlipemia, hypertension, migraine, myocardial infarct, myocardial ischemia, occlusion, peripheral vascular disorder, syncope, and tachycardia.
Digestive System: Anorexia, constipation, dry mouth, dysphagia, colitis, fecal incontinence, gastritis, gastroenteritis, gastrointestinal disorder, increased appetite, intestinal obstruction, melena, pancreatitis, tenesmus, and vomiting.
Hematologic-Lymphatic System: Lymphadenopathy.
Infections and Infestations: Viral infection.
Metabolic and Nutritional Disorders: Edema, hyperglycemia, increased ALT, and increased AST.
Musculoskeletal System: Arthralgia, arthritis, myalgia, pathological fracture, and tendon disorder.
Nervous System: Central nervous system neoplasia, depression, dizziness, emotional lability, facial paralysis, insomnia, vasodilatation, and vertigo.
Respiratory System: Asthma, bronchitis, increased cough, dyspnea, epistaxis, laryngitis, pharyngitis, pneumonia, rhinitis, and sinusitis.
Skin: Alopecia, eczema, pruritus, and sweating.
Special Senses: Cataract.
Urogenital System: Cervix disorder, endometrial carcinoma, epididymitis, and impotence.
Siluma contraindications
Hypersensitivity to milk thistle fruits and/or other plants of the compositae, or to any of the excipients of Siluma.
Active ingredient matches for Siluma:
Silibinin in Taiwan.
Unit description / dosage (Manufacturer) | Price, USD |
Siluma 70 mg | |
List of Siluma substitutes (brand and generic names): | |
Silmar (Colombia) | |
Silvaysan (Germany) | |
Capsule; Oral; Milk Thistle (Sanum-kehlbeck) | |
Silybon (India) | |
Silybon 70mg TAB / 10 (Micro Labs Ltd) | $ 0.70 |
Silybon 140mg TAB / 10 (Micro Labs Ltd) | $ 0.94 |
Silybon 35mg/5mL SUSP / 100ml (Micro Labs Ltd) | $ 1.04 |
Silybon 35mg/5mL SUSP / 200ml (Micro Labs Ltd) | $ 1.81 |
Silybon 200 ml Suspension (Micro Labs Ltd) | $ 0.05 |
Silybon 140 mg Tablet (Micro Labs Ltd) | $ 0.11 |
Silybon 100 ml Suspension (Micro Labs Ltd) | $ 0.06 |
Silybon 70 mg Tablet (Micro Labs Ltd) | $ 0.08 |
SILYBON 35 MG SUSPENSION 1 bottle / 100 ML suspension each (Micro Labs Ltd) | $ 1.54 |
SILYBON 35 MG SUSPENSION 1 bottle / 200 ML suspension each (Micro Labs Ltd) | $ 2.71 |
SILYBON 35 MG SUSPENSION 1 bottle / 60 ML suspension each (Micro Labs Ltd) | $ 1.54 |
SILYBON 70 MG TABLET 1 strip / 10 tablets each (Micro Labs Ltd) | $ 1.05 |
SILYBON film-coated tab 70 mg x 10's (Micro Labs Ltd) | $ 0.70 |
SILYBON film-coated tab 140 mg x 10's (Micro Labs Ltd) | $ 0.94 |
SILYBON oral susp 35 mg x 5 mL x 100ml (Micro Labs Ltd) | $ 1.20 |
SILYBON oral susp 35 mg x 5 mL x 200ml (Micro Labs Ltd) | $ 1.81 |
Silybon 35mg Suspension (Micro Labs Ltd) | $ 2.96 |
Silybon 70mg Tablet (Micro Labs Ltd) | $ 0.11 |
Silycon (Taiwan) | |
Silycon 150 mg x 1000's | |
Silygal (Czech Republic) | |
Silygamma 150mg (Vietnam) | |
Silygamma 86.5 mg (Hungary) | |
Silygen (Taiwan) | |
Silygen / S.Y. 150 mg | |
Silygen / Standard 1000's | |
Silygen / Standard Blister pk | |
Silygen-F (Taiwan) | |
Silygen-F 35 mg x 1000's | |
Silygen-H (Taiwan) | |
Silygen-H 150 mg x 1000's | |
Silyhep (Taiwan) | |
Silyhep / Kojar 150 mg | |
Silyhep / Souriree 5 x 6's | |
Silyhep / Souriree 30 x 6's | |
Silyhep 150 mg x 10 Blister x 10 Tablet | |
Silyma (Taiwan) | |
Silyma 150 mg | |
Silyman (South Korea) | |
Silymarin (Bosnia & Herzegowina, Hong Kong, Oman, Taiwan) | |
Capsule; Oral; Milk Thistle 70 mg (Sedico impex) | |
Capsule; Oral; Milk Thistle 140 mg (Sedico impex) | |
Capsule; Oral; Milk Thistle 200 mg (Sedico impex) | |
Capsule; Oral; Milk Thistle 110 mg (Sedico impex) | |
Silymarin / Tai Yu 70 mg (Sedico impex) | |
Silymarin 70 mg x 30's (Sedico impex) | |
Silymarin 70 mg x 1, 000's (Sedico impex) | |
See 447 substitutes for Siluma |
References
- PubChem. "silibinin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Silibinin A". http://www.drugbank.ca/drugs/DB09298 (accessed September 17, 2018).
- DTP/NCI. "NSC651520: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Siluma are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Siluma. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology