Silygen-H indications
Pernicious anemia, both uncomplicated and accompanied by nervous system involvement.
Dietary deficiency of Vitamin B12, occurring in strict vegetarians and in their breast-fed infants. (Isolated vitamin B12 deficiency is very rare).
Malabsorption of vitamin B12, resulting from structural or functional damage to the stomach, where intrinsic factor is secreted or to the ileum, where intrinsic factor facilitates vitamin B12 absorption. These conditions include tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than vitamin B12 deficiency.
Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces vitamin B12 deficiency.
Structural lesions leading to vitamin B12 deficiency include regional ileitis, ileal resections, malignancies, etc.
Competition for Vitamin B12 by intestinal parasites or bacteria.
The fish tapeworm (Diphyilobothrium latum) absorbs huge quantities of vitamin B12 and infested patients often have associated gastric atrophy. The blind-loop syndrome may produce deficiency of Vitamin B12 or folate.
Inadequate utilization of vitamin B12. This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.
For the Schilling Test.
Uses of Silygen-H in details
Silygen-H is a liver protectant and antioxidant. Treatment with Silygen-H has shown slightly improved liver function, and showed improvement in patients with type 2 diabetes and diabetic nephropathy (kidney disease).
Silygen-H description
Each 70-mg capsule contains Silygen-H 70 mg (calculated as Silygen-H) in dried extract of milk thistle fruits 86.5-93.3 mg while the 140-mg capsule contains Silygen-H 140 mg (calculated as Silygen-H) in dried extract of milk thistle fruits 173-186.6 mg.
Silygen-H dosage
Unless otherwise directed by the physician: Adults and Children >12 years: Usual Dose: Initially, 1 cap 3 times daily.
Maintenance Dose: 1 cap 2 times daily.
Administration: Silygen-H should be taken whole with some liquid before meals.
The physician should decide on the length of treatment.
Silygen-H interactions
Fish lipid oil prevents blood clotting too quickly, therefore patients who are treated with anticoagulants must consult their doctor before taking Silygen-H.
Silygen-H side effects
Body as a Whole: Enlarged abdomen, asthenia, body odor, chest pain, chills, suicide, fever, generalized edema, fungal infection, malaise, neck pain, neoplasm, rheumatoid arthritis, and sudden death.
Cardiovascular System: Arrhythmia, bypass surgery, cardiac arrest, hyperlipemia, hypertension, migraine, myocardial infarct, myocardial ischemia, occlusion, peripheral vascular disorder, syncope, and tachycardia.
Digestive System: Anorexia, constipation, dry mouth, dysphagia, colitis, fecal incontinence, gastritis, gastroenteritis, gastrointestinal disorder, increased appetite, intestinal obstruction, melena, pancreatitis, tenesmus, and vomiting.
Hematologic-Lymphatic System: Lymphadenopathy.
Infections and Infestations: Viral infection.
Metabolic and Nutritional Disorders: Edema, hyperglycemia, increased ALT, and increased AST.
Musculoskeletal System: Arthralgia, arthritis, myalgia, pathological fracture, and tendon disorder.
Nervous System: Central nervous system neoplasia, depression, dizziness, emotional lability, facial paralysis, insomnia, vasodilatation, and vertigo.
Respiratory System: Asthma, bronchitis, increased cough, dyspnea, epistaxis, laryngitis, pharyngitis, pneumonia, rhinitis, and sinusitis.
Skin: Alopecia, eczema, pruritus, and sweating.
Special Senses: Cataract.
Urogenital System: Cervix disorder, endometrial carcinoma, epididymitis, and impotence.
Silygen-H contraindications
Hypersensitivity to milk thistle fruits and/or other plants of the compositae, or to any of the excipients of Silygen-H.
Active ingredient matches for Silygen-H:
Silibinin in Taiwan.
| Unit description / dosage (Manufacturer) | Price, USD |
| Silygen-H 150 mg x 1000's | |
List of Silygen-H substitutes (brand and generic names): | |
| Silygen-F (Taiwan) | |
| Silygen-F 35 mg x 1000's | |
| Silyhep (Taiwan) | |
| Silyhep / Kojar 150 mg | |
| Silyhep / Souriree 5 x 6's | |
| Silyhep / Souriree 30 x 6's | |
| Silyhep 150 mg x 10 Blister x 10 Tablet | |
| Silyma (Taiwan) | |
| Silyma 150 mg | |
| Silyman (South Korea) | |
| Silymarin (Bosnia & Herzegowina, Hong Kong, Oman, Taiwan) | |
| Capsule; Oral; Milk Thistle 70 mg (Sedico impex) | |
| Capsule; Oral; Milk Thistle 140 mg (Sedico impex) | |
| Capsule; Oral; Milk Thistle 200 mg (Sedico impex) | |
| Capsule; Oral; Milk Thistle 110 mg (Sedico impex) | |
| Silymarin / Tai Yu 70 mg (Sedico impex) | |
| Silymarin 70 mg x 30's (Sedico impex) | |
| Silymarin 70 mg x 1, 000's (Sedico impex) | |
| Silymarin / S.C. 35 mg (Sedico impex) | |
| Silymarin / S.C. 150 mg (Sedico impex) | |
| Silymarin / Biome 150 mg (Sedico impex) | |
| Silymarin / P.L. 70 mg x 1000's (Sedico impex) | |
| Silymarin AL (Czech Republic, Germany) | |
| Silymarin Belupo (Croatia (Hrvatska)) | |
| Silymarin dura (Germany) | |
| Silymarin Forte (Bosnia & Herzegowina) | |
| Silymarin Forte Belupo (Bosnia & Herzegowina) | |
| Silymarin Instant (Romania) | |
| Silymarin Sedico (Egypt) | |
| Silymarin Siromed (Lithuania) | |
| Silymarin Stada (Germany) | |
| Silymarin Vramed (Bulgaria) | |
| Silymarin-CT (Germany) | |
| Silymarin-Hexal (Luxembourg) | |
| Silyme-V (Taiwan) | |
| Silyme-V 70 mg | |
| Silymin (Taiwan) | |
| Silymin 150 mg | |
| Silyrin (India) | |
| Silyrin 35mg/5mL SUSP / 100ml (Talent Laboratories) | $ 0.72 |
| Silyrin -140 3 Blister x 10 Tablet (Talent Laboratories) | |
| Silyrin -70 3 Blister x 10 Tablet (Talent Laboratories) | |
| Silyrin 100 ml Suspension (Talent Laboratories) | $ 0.04 |
| Silyrin 140 mg Tablet (Talent Laboratories) | $ 0.07 |
| Silyrin 70 mg Tablet (Talent Laboratories) | $ 0.04 |
| Simepar Forte (Estonia, Latvia) | |
| Sison (India) | |
| Sison 70mg CAP / 10 (Dr Alson Laboratories Pvt Ltd) | $ 0.51 |
| Sison 140mg CAP / 10 (Dr Alson Laboratories Pvt Ltd) | $ 0.90 |
| 70 mg x 10's (Dr Alson Laboratories Pvt Ltd) | $ 0.51 |
See 447 substitutes for Silygen-H | |
References
- PubChem. "silibinin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Silibinin A". http://www.drugbank.ca/drugs/DB09298 (accessed September 17, 2018).
- DTP/NCI. "NSC651520: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Silygen-H are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Silygen-H. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yet1 consumer reported price estimates
Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Silygen-H drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
| Users | % | ||
|---|---|---|---|
| Not expensive | 1 | 100.0% | |
Consumer reported time for results
No survey data has been collected yetConsumer reported age
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Information checked by Dr. Sachin Kumar, MD Pharmacology
