• Folac indications
• Uses of Folac in details
• Folac description
• Folac dosage
• Folac interactions
• Folac side effects
• Folac contraindications

What is Folac?

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Folac (vitamin B 9) is necessary for strong blood.

Lack of Folac may lead to anemia (weak blood). Your health care professional may treat this by prescribing Folac for you.

Some conditions may increase your need for Folac. These include:

• Alcoholism
• Anemia, hemolytic
• Diarrhea (continuing)
• Fever (prolonged)
• Hemodialysis
• Illness (prolonged)
• Intestinal diseases
• Liver disease
• Stress (continuing)
• Surgical removal of stomach

In addition, infants smaller than normal, breast-fed infants, or those receiving unfortified formulas (such as evaporated milk or goat's milk) may need additional Folac.

Increased need for Folac should be determined by your health care professional.

Some studies have found that Folac taken by women before they become pregnant and during early pregnancy may reduce the chances of certain birth defects (neural tube defects).

Claims that Folac and other B vitamins are effective for preventing mental problems have not been proven. Many of these treatments involve large and expensive amounts of vitamins.

Injectable Folac is given by or under the direction of your health care professional. Another form of Folac is available without a prescription.

Folac indications

Folac is used in the treatment and prevention of the folate deficiency state. It does not correct folate deficiency due to dihydrofolate reductase inhibitors. Folac is also used in women of child-bearing potential and pregnant women to protect against neural tube defects in their offspring. It is also used for the treatment of folate-deficient megaloblastic anaemia, chronic haemolytic states such as thalassaemia major or sickle-cell anaemia.

How should I use Folac?

Use Folac as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Folac may be administered as an injection by your health care professional.
• If you are using Folac at home, carefully follow the injection procedures taught to you by your health care provider. If the medicine contains particles, is discolored, or if the vial is cracked or damaged in any way, do not use it.
• Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
• If you miss a dose of Folac, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Folac.

Uses of Folac in details

Folac is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.

Folac supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of Folac either through their diet or supplements to prevent infant spinal cord birth defects.

How to use Folac

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition persists or worsens, or if you think you may have a serious medical problem, get medical help right away.

Folac description

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folac is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]

Folac dosage

Folac Dosage

Applies to the following strength(s): 1 mg; 0.4 mg; 5 mg/mL; 0.8 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

• Megaloblastic Anemia
• Folac Deficiency

Usual Pediatric Dose for:

• Folac Deficiency
• Vitamin/Mineral Supplementation

Additional dosage information:

• Renal Dose Adjustments
• Liver Dose Adjustments
• Dose Adjustments
• Dialysis
• Other Comments

Usual Adult Dose for Megaloblastic Anemia

1 mg orally, intramuscularly, subcutaneously or IV once a day. May continue until clinical symptoms of folate deficiency and the hematological profile have normalized.

Usual Adult Dose for Folac Deficiency

400 to 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Women of childbearing age, pregnant, and lactating women: 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Folac Deficiency

Infant:

0.1 mg orally, intramuscularly, subcutaneously or IV once a day.

Child:

Less than 4 years: up to 0.3 mg orally, intramuscularly, subcutaneously or IV once a day.

4 years or older: 0.4 mg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Vitamin/Mineral Supplementation

Recommended daily allowance (RDA):

Premature neonates: 50 mcg/day (15 mcg/kg/day).

Full-term neonates and infants 1 to 6 months: 25 to 35 mcg/day.

Children:

1 to 3 years: 150 mcg/day.

4 to 8 years: 200 mcg/day.

9 to 13 years: 300 mcg/day.

14 years and older: 400 mcg/day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Rarely, a dosage of 2 mg/day may be required, particularly in patients with malabsorption, alcoholism, chronic hemolysis, chronic exfoliative skin disease or who are on concomitant anticonvulsant therapy.

Dialysis

Folac is removed by both hemodialysis and peritoneal dialysis. The amount removed varies with type equipment used.

Because folate may accumulate in patients with end-stage renal disease, side effects may be more likely in this patient who is undergoing dialysis. Once this patient's body stores of folate are replete, three times a week dosing may be just as beneficial as once daily dosing but should portend a lower risk of side effects.

Other Comments

The recommended daily allowance of Folac for adult males and females ranges from 150 to 200 and 150 to 180 mcg/day, respectively.

There is a potential danger in administering Folac to patients with undiagnosed anemia, since Folac may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress.

Severe megaloblastic anemia may require therapy for 4 to 5 weeks. Once stabilized, if dietary intake is inadequate, maintenance therapy can be started.

More about Folac

• Side Effects
• During Pregnancy
• Dosage Information
• Drug Images
• Drug Interactions
• Support Group
• Pricing & Coupons
• En Espanol
• 0 Reviews - Add your own review/rating

Consumer resources

• Folac
• Folac capsules
• Folac

  Oral, Injection (Advanced Reading)

• Other brands: Folacin-800, Folac

Professional resources

• Folac (AHFS Monograph)
• More (3) »

Related treatment guides

• Folac Deficiency
• Vitamin/Mineral Supplementation and Deficiency
• Anemia, Megaloblastic

Folac interactions

See also:
What other drugs will affect Folac?

Medications that interfere with your bodys ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and Folac. Folac supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, Folac will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental Folac should not exceed 1000 micrograms (g, sometimes mcg) per day to prevent Folac from masking symptoms of vitamin B12 deficiency. It is important for older adults to be aware of the relationship between Folac and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains Folic Acid.

Folac side effects

See also:
What are the possible side effects of Folac?

Allergic sensitization has been reported following both oral and parenteral administration of Folac.

Folac is relatively nontoxic in man. Rare instances of allergic responses to Folac preparations have been reported and have included erythema, skin rash, itching, general malaise, and respiratory difficulty due to bronchospasm. One patient experienced symptoms suggesting anaphylaxis following injection of the drug. Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg Folac daily for 1 month. Other side effects reported in patients receiving 15 mg daily include altered sleep patterns, difficulty in concentrating, irritability, overactivity, excitement, mental depression, confusion, and impaired judgment. Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folac therapy.

In an uncontrolled study, orally administered Folac was reported to increase the incidence of seizures in some epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin. Another investigator reported decreased diphenylhydantoin serum levels in folate-deficient patients receiving diphenylhydantoin who were treated with 5 mg or 15 mg of Folac daily.

CALL YOUR DOCTOR FOR MEDICAL ADVICE ABOUT SIDE EFFECTS. YOU MAY REPORT SIDE EFFECTS TO THE FDA AT 1-800-FDA-1088 OR LEADING PHARMA, LLC AT 844-740-7500.

Folac contraindications

See also:
What is the most important information I should know about Folac?

Because it may mask the hematologic abnormalities while neurological damage progresses, Folac should not be used in the therapy of patients with vitamin B12 deficiency of any cause, unless there is associated folate deficiency. The Folac content of one tablet a day however, is unlikely to mask pernicious anemia should this condition be present. Also, pregnancy during pernicious anemia is very rare.

Active ingredient matches for Folac:

Folic Acid in Indonesia, Venezuela.

Unit description / dosage (Manufacturer)	Price, USD
Folac 400 mcg x 100's	$ 7.44
Folac tab 5 mg 100's (North China Pharma)
List of Folac substitutes (brand and generic names):
FOL-S (India)
FOL-S tab 5 mg x 10's (Iscon)	$ 0.14
Folacal
Capsule; Oral; Folic Acid / Calcium Folinate 0.745 mg
Folacid (Chile, Poland)
Tablet; Oral; Folic Acid 5 mg (Shalina Laboratories Ltd)
Folacid 5 mg x 100's (Shalina Laboratories Ltd)
Folacid 5 mg Tablet (Shalina Laboratories Ltd)	$ 0.00
Folacid cap 5 mg 100's (Shalina Laboratories Ltd)
Folacin (Bosnia & Herzegowina, Brazil, Croatia (Hrvatska), Russian Federation, Serbia, Slovenia, Sweden, Taiwan)
Tablet; Oral; Folic Acid 5 mg (Mars Therapeutics & Chemicals Ltd)
Folacin 5 mg x 84's (Mars Therapeutics & Chemicals Ltd)
Folacin 5 mg x 500's (Mars Therapeutics & Chemicals Ltd)
Folacin 5 mg x 1000's (Mars Therapeutics & Chemicals Ltd)
5 mg x 10's (Mars Therapeutics & Chemicals Ltd)	$ 0.14
Folacin 5mg TAB / 10 (Mars Therapeutics & Chemicals Ltd)	$ 0.14
Folacin 5 mg Tablet (Mars Therapeutics & Chemicals Ltd)	$ 0.01
FOLACIN tab 5 mg x 10's (Mars Therapeutics & Chemicals Ltd)	$ 0.14
Folacin Tablets
Folacin-800
Folacina (Argentina)
Folacite (Indonesia)
Folacite 400 (Indonesia)
Folacite 400 400 mcg x 100's	$ 6.27
Folacom (Indonesia)
Folacom 400 mcg x 3 x 10's (Combiphar)	$ 1.77
Foladin (Philippines)
Foladin tab 5 mg 100's (JRalph Pharma)	$ 12.78
Folaemin
FOLAID (India)
5 mg x 28's (Medi-Genix (Sterling Lab))	$ 0.29
Folaid 5mg TAB / 28 (Medi-Genix (Sterling Lab))	$ 0.29
Folaid 5 mg Tablet (Medi-Genix (Sterling Lab))	$ 0.01
FOLAID tab 5 mg x 28's (Medi-Genix (Sterling Lab))	$ 0.29
Folaid 5mg TAB / 28 (Medi-Genix (Sterling Lab))	$ 0.29
Folan (Serbia)
Folarell (Germany)
Injectable; Injection; Folic Acid (Sanorell)
Tablet; Oral; Folic Acid (Sanorell)
Folart (Philippines)
Folart 5 mg x 100's	$ 16.82
Folart 5 mg/5 mL x 60 mL	$ 2.00
Folart 5 mg/5 mL x 120 mL	$ 3.56
Folart 2.5 mg/1 mL x 30 mL	$ 2.22
Folas (Indonesia)
Folas 400 mcg x 10 x 10's (Landson)	$ 8.07
Folasic (Australia)
FOLAT-5 (India)
5 mg x 10's (ATOZ)	$ 0.11
Folat-5 5mg TAB / 10 (ATOZ)	$ 0.11
FOLAT-5 tab 5 mg x 10's (ATOZ)	$ 0.11
Folat-5 5mg TAB / 10 (ATOZ)	$ 0.11
Folate (India)
FOLATE film-coated tab 5 mg x 10's (Katg)	$ 0.19
Folatine (United Kingdom)
See 1354 substitutes for Folac

References

1. DailyMed. "ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PHYTONADIONE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN 5'-PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "folic acid". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "folic acid". http://www.drugbank.ca/drugs/DB00158 (accessed September 17, 2018).

Reviews

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Information checked by Dr. Sachin Kumar, MD Pharmacology