Nidkof-A indications
For use Max Pidek Pharmaceuticals as monotherapy and in combination with clavulanic acid: an infectious-inflammatory diseases caused by susceptible microorganisms, including bronchitis, pneumonia, tonsillitis, pyelonephritis, urethritis, infections of the gastrointestinal tract, gynecological infections, infections of the skin and soft tissue, listeria, leptospirosis, gonorrhea.
For use Max Pidek Pharmaceuticals in combination with metronidazole: chronic gastritis in acute, peptic ulcer and duodenal ulcer in acute, associated with Helicobacter Pylori.
Uses of Nidkof-A in details
Nidkof-A is used to treat certain diseases of the respiratory tract and to relieve cough associated with thickened mucous.
Nidkof-A description
Each retard capsule contains Ambroxol hydrochloride 75 mg.
Each tablet contains Ambroxol hydrochloride 30 mg.
Each 5 mL of syrup contains Ambroxol hydrochloride 15 or 30 mg.
Each mL of syrup (infant drops) contains Ambroxol hydrochloride 6 mg.
Nidkof-A hydrochloride is trans-4-[(2-amino-3,5-dibromo-benzyl)amino] cyclohexanol hydrochloride.
It also contains the following excipients: Retard Capsules: Crospovidone collidon CL, carnauba wax, stearyl alcohol, magnesium stearate.
Tablets: Lactose, maize starch, colloidal silica, magnesium stearate.
Syrup: Purified water, sorbitol liquid, glycerol 85%, woodberry aroma (15 mg only), strawberry aroma (30 mg only), hydroxyethylcellulose, benzoic acid, acesulfame potassium, vanilla aroma.
Infant Drops: Hydroxyethylcellulose, sorbitol solution, glycerol 85%, sodium saccharin, pharma flavors, menthol, benzoic acid, propylene glycol.
Nidkof-A dosage
Sustained-Release Capsule: Adults and Children >12 years: 1 cap once daily after meal with plenty of liquid (sufficient supply of liquid supports the expectorant effect of Nidkof-A).
Nidkof-A SR capsule is not suitable for children <12 years.
Tablet: Adults and Children >12 years: 1 tab thrice daily for the first 2-3 days and then 1 tab twice daily or ½ tab thrice daily. Children 6-12 years: ½ tab 2-3 times a day.
Syrup: Adults and Children >12 years: 10 mL thrice daily during the first 2-3 days, them 10 mL twice daily or 5 mL thrice daily. Children 6-12 years: 5 mL 2-3 times a day; 2-5 years: 2.5 mL 3 times a day; <2 years: 2.5 mL 2 times a day.
DS Syrup: Adults and Children >12 years: 5 mL thrice daily for 2-3 days then 5 mL twice daily for 2.5 mL thrice daily. Children 6-12 years: 2.5 mL 2-3 times a day.
Infant Drops: Children 13-24 months: 1.25 mL twice a day; 7-12 months: 1 mL twice a day; ≤6 months: 0.5 mL twice a day.
Nidkof-A interactions
Amoxicillin may decrease the effectiveness of contraceptives for oral administration.
With the simultaneous use of Max Pidek Pharmaceuticals with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) appears synergies; with bacteriostatic antibiotic (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulphonamide) - antagonism.
Amoxicillin increases the effects of indirect anticoagulants inhibiting intestinal microflora, reduces the synthesis of vitamin K and prothrombin index.
Amoxicillin reduces the effect of drugs, in the process of metabolism that produce PABA.
Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs decrease the tubular secretion of amoxicillin, which can be accompanied by an increase in its concentration in blood plasma.
Antacids, glucosamine, laxatives, aminoglycosides, slow down and reduce, and ascorbic acid increases the absorption of amoxicillin.
With the combined use of amoxicillin and clavulanic acid pharmacokinetics of both components unchanged.
Nidkof-A side effects
Allergic reactions: urticaria, erythema, edema Quincke, rhinitis, conjunctivitis, rarely - fever, joint pain, eosinophilia, in rare cases - anaphylactic shock.
Side effects associated with chemotherapy effect: possible development of super-infection (particularly in patients with chronic diseases or low resistance of the organism).
With prolonged use at high doses: dizziness, ataxia, confusion, depression, peripheral neuropathy, seizures.
Mostly when Max Pidek Pharmaceuticals used in combination with metronidazole: nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis; rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, a violation of hematopoiesis.
Mostly when Max Pidek Pharmaceuticals used in combination with clavulanic acid: cholestatic jaundice, hepatitis, rarely - erythema multiforme, toxic epidermal necrolysis, exfoliative dermatitis.
Nidkof-A contraindications
Hypersensitivity to Nidkof-A hydrochloride or to any other excipients of Nidkof-A.
In case of rare hereditary conditions that may be incompatible with an excipient of Nidkof-A, the use of Nidkof-A is contraindicated.
Active ingredient matches for Nidkof-A:
Ambroxol in India.
Guaiphenesin/menthol/terbutaline in India.
| Unit description / dosage (Manufacturer) | Price, USD |
| Nidkof-A Ambroxol 15 mg, guaiphenesin50 mg, terbutaline 1.5 mg, menthol 1 mg. SYR / 100ml | $ 0.57 |
| NIDKOF-A syr 100ml (Nidus) | $ 0.57 |
List of Nidkof-A substitutes (brand and generic names): | |
| Nibren (Greece) | |
| Nizla Plus (India) | |
| Nizla Plus Levocetirizine dihydrochloride2.5 mg, Ambroxol 60 mg, Paracetamol 500 mg. TAB / 200 (Scoshia) | $ 9.64 |
| 200's (Scoshia) | $ 9.64 |
| NIZLA PLUS tab 10's (Scoshia) | $ 0.48 |
| Nontas (Japan) | |
| Nopuff-A (India) | |
| Nopuff-A Ambroxol 15 mg, guaiphenesin50 mg, terbutaline 1.5 mg, menthol 1 mg. SYR / 100ml (Medilente) | $ 0.67 |
| NOPUFF-A syr 100ml (Medilente) | $ 0.67 |
| Notus AT | |
| Notus AT 100 ml Expectorant (Chem Biotech Healthcare) | $ 0.03 |
| Novamox-AX (India) | |
| Novamox-AX Amoxicillin 500 mg, Ambroxolhydrochloride 30 mg, Amoxycillin 250 mg, Ambroxolhydrochloride 30 mg. TAB / 6 (Cipla) | $ 0.52 |
| Novamox-AX Amoxicillin 500 mg, Ambroxolhydrochloride 30 mg, Amoxycillin 250 mg, Ambroxolhydrochloride 30 mg. TAB / 15 (Cipla) | $ 0.77 |
| Novamox-AX Amoxycillin 250 mg, Ambroxolhydrochloride 15 mg. SYR / 60ml (Cipla) | $ 0.73 |
| Novamox-AX Amoxicillin 250mg, AmbroxolHCI 30mg TAB / 15 (Cipla) | $ 0.77 |
| Novamox-AX Amoxicillin 500mg, AmbroxolHCI 30mg TAB / 6 (Cipla) | $ 0.52 |
| Novamox-AX Amoxicillin 250mg, AmbroxolHCI 15mg RU-SYR / 60ml (Cipla) | $ 0.73 |
| 6's (Cipla) | $ 0.52 |
| 15's (Cipla) | $ 0.77 |
| 60ml (Cipla) | $ 0.73 |
| NOVAMOX-AX tab 6's (Cipla) | $ 0.52 |
| NOVAMOX-AX tab 15's (Cipla) | $ 0.77 |
| NOVAMOX-AX syr 60ml (Cipla) | $ 0.73 |
| Novex Ambroxol (Georgia) | |
| Nozik (India) | |
| Nozik Cetirizine 5 mg, Ambroxol 60mg. TAB / 10 (Candor (Aileron)) | |
| Nozik Cetirizine 2.5 mg, Ambroxol 30mg. SYR / 60ml (Candor (Aileron)) | |
| Nozik Cetirizine 5 mg, Ambroxol 60mg TAB / 10 (Candor (Aileron)) | |
| 10's (Candor (Aileron)) | |
| 60ml (Candor (Aileron)) | |
| NOZIK tab 10's (Candor (Aileron)) | |
| NOZIK syr 60ml (Candor (Aileron)) | |
| NT-KUF-AM (India) | |
| NT-KUF-AM Ambroxol hydrochloride 15 mg, Guaiphenesin 50 mg, Terbutaline sulphate 1.5 mg, Menthol 1 mg. SYR / 100ml (Hauz) | $ 0.58 |
| 100ml (Hauz) | $ 0.58 |
| Nt-Kuf-Am Terbutaline sulphate 1.25 mg, Bromhexine hydrochloride 2 mg, Guaiphenesin 50 mg. SYR / 100ml (Hauz) | $ 0.54 |
| NT-KUF-AM syr 100ml (Hauz) | $ 0.58 |
| Nt-Kuf-Am Terbutaline sulphate 1.25 mg, Bromhexine hydrochloride 2 mg, Guaiphenesin 50 mg. SYR / 100ml (Hauz) | $ 0.54 |
| Nucobrox (Thailand) | |
| Nucobrox 30 mg x 500's (Bangkok Lab & Cosmetic) | |
| Nucobrox 30 mg x 5 x 10 x 10's (Bangkok Lab & Cosmetic) | |
| Nucobrox 30 mg/5 mL x 60 mL x 12's (Bangkok Lab & Cosmetic) | |
| Nucobrox 30 mg/5 mL x 50's (Bangkok Lab & Cosmetic) | |
| Nucobrox syr 30 mg/5 mL 50 x 1's (Bangkok Lab & Cosmetic) | |
| Nucobrox syr 30 mg/5 mL 60 mL x 12 x 1's (Bangkok Lab & Cosmetic) | |
| Nucobrox tab 30 mg 5 x 10 x 10's (Bangkok Lab & Cosmetic) | |
| Nucobrox tab 30 mg 500's (Bangkok Lab & Cosmetic) | |
| Nucope-AD (India) | |
| Nucope-AD Desloratadine 5 mg, Pseudoephedrine 30 mg, Ambroxol 60 mg. FC-TAB / 10 (Mankind (Discovery)) | $ 0.28 |
See 3104 substitutes for Nidkof-A | |
References
- DailyMed. "TERBUTALINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "terbutaline". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "ambroxol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
