Silimarin indications
Pernicious anemia, both uncomplicated and accompanied by nervous system involvement.
Dietary deficiency of Vitamin B12, occurring in strict vegetarians and in their breast-fed infants. (Isolated vitamin B12 deficiency is very rare).
Malabsorption of vitamin B12, resulting from structural or functional damage to the stomach, where intrinsic factor is secreted or to the ileum, where intrinsic factor facilitates vitamin B12 absorption. These conditions include tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than vitamin B12 deficiency.
Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces vitamin B12 deficiency.
Structural lesions leading to vitamin B12 deficiency include regional ileitis, ileal resections, malignancies, etc.
Competition for Vitamin B12 by intestinal parasites or bacteria.
The fish tapeworm (Diphyilobothrium latum) absorbs huge quantities of vitamin B12 and infested patients often have associated gastric atrophy. The blind-loop syndrome may produce deficiency of Vitamin B12 or folate.
Inadequate utilization of vitamin B12. This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.
For the Schilling Test.
Uses of Silimarin in details
Silimarin is a liver protectant and antioxidant. Treatment with Silimarin has shown slightly improved liver function, and showed improvement in patients with type 2 diabetes and diabetic nephropathy (kidney disease).
Silimarin description
Each 70-mg capsule contains Silimarin 70 mg (calculated as Silimarin) in dried extract of Silimarin fruits 86.5-93.3 mg while the 140-mg capsule contains Silimarin 140 mg (calculated as Silimarin) in dried extract of Silimarin fruits 173-186.6 mg.
Silimarin dosage
Unless otherwise directed by the physician: Adults and Children >12 years: Usual Dose: Initially, 1 cap 3 times daily.
Maintenance Dose: 1 cap 2 times daily.
Administration: Silimarin should be taken whole with some liquid before meals.
The physician should decide on the length of treatment.
Silimarin interactions
Fish lipid oil prevents blood clotting too quickly, therefore patients who are treated with anticoagulants must consult their doctor before taking Silimarin.
Silimarin side effects
Body as a Whole: Enlarged abdomen, asthenia, body odor, chest pain, chills, suicide, fever, generalized edema, fungal infection, malaise, neck pain, neoplasm, rheumatoid arthritis, and sudden death.
Cardiovascular System: Arrhythmia, bypass surgery, cardiac arrest, hyperlipemia, hypertension, migraine, myocardial infarct, myocardial ischemia, occlusion, peripheral vascular disorder, syncope, and tachycardia.
Digestive System: Anorexia, constipation, dry mouth, dysphagia, colitis, fecal incontinence, gastritis, gastroenteritis, gastrointestinal disorder, increased appetite, intestinal obstruction, melena, pancreatitis, tenesmus, and vomiting.
Hematologic-Lymphatic System: Lymphadenopathy.
Infections and Infestations: Viral infection.
Metabolic and Nutritional Disorders: Edema, hyperglycemia, increased ALT, and increased AST.
Musculoskeletal System: Arthralgia, arthritis, myalgia, pathological fracture, and tendon disorder.
Nervous System: Central nervous system neoplasia, depression, dizziness, emotional lability, facial paralysis, insomnia, vasodilatation, and vertigo.
Respiratory System: Asthma, bronchitis, increased cough, dyspnea, epistaxis, laryngitis, pharyngitis, pneumonia, rhinitis, and sinusitis.
Skin: Alopecia, eczema, pruritus, and sweating.
Special Senses: Cataract.
Urogenital System: Cervix disorder, endometrial carcinoma, epididymitis, and impotence.
Silimarin contraindications
Hypersensitivity to Silimarin fruits and/or other plants of the compositae, or to any of the excipients of Silimarin.
Active ingredient matches for Silimarin:
Silibinin in Italy.
Milk thistle in Italy.
List of Silimarin substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Silimar (India) | |
| SILIMAR cap 140 mg x 10's (German Remedies (Zydus Cadila Healthcare Ltd.)) | $ 0.74 |
| Silimarinã (Romania) | |
| Silimarina (Colombia) | |
| Silimarina Bawiss (Colombia) | |
| Silimarinã Biofarm (Romania) | |
| Silimarina Disfarm (Uruguay) | |
| Silimarinã Fabiol (Romania) | |
| Silimarina Genfar (Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Nicaragua) | |
| Silimarina Pharma Arte (Paraguay) | |
| Silimarina Sedico | |
| Silimarit (Germany) | |
| Capsule; Oral; Milk Thistle (Bionorica) | |
| Silimax (Poland) | |
| Silime (Ecuador) | |
| Silimin (Taiwan) | |
| Silimin 150 mg x 30's | |
| Silimin 150 mg x 1000's | |
| Silin (Taiwan) | |
| Silin 100 mg | |
| Silirin (Taiwan) | |
| Silirin 150 mg x 3 x 10's, 60's, 100 x 10's, 1000's | |
| SILIV (India) | |
| 70 mg x 10's (Finecure Pharmaceuticals Ltd) | |
| 140 mg x 10's (Finecure Pharmaceuticals Ltd) | |
| 35 mg x 5 mL x 100ml (Finecure Pharmaceuticals Ltd) | |
| Siliv 70mg TAB / 10 (Finecure Pharmaceuticals Ltd) | |
| Siliv 140mg TAB / 10 (Finecure Pharmaceuticals Ltd) | |
| Siliv 35mg x 5mL SUSP / 100ml (Finecure Pharmaceuticals Ltd) | |
| Siliv 140 mg Tablet (Finecure Pharmaceuticals Ltd) | $ 0.06 |
| Siliv 100 ml Suspension (Finecure Pharmaceuticals Ltd) | $ 0.03 |
| Siliv 70 mg Tablet (Finecure Pharmaceuticals Ltd) | $ 0.04 |
| SILIV tab 70 mg x 10's (Finecure Pharmaceuticals Ltd) | $ 0.41 |
| SILIV tab 140 mg x 10's (Finecure Pharmaceuticals Ltd) | $ 0.60 |
| SILIV oral susp 35 mg x 5 mL x 100ml (Finecure Pharmaceuticals Ltd) | $ 0.66 |
| Siliv 70mg TAB / 10 (Finecure Pharmaceuticals Ltd) | |
| Siliv 140mg TAB / 10 (Finecure Pharmaceuticals Ltd) | |
| Siliv 35mg x 5mL SUSP / 100ml (Finecure Pharmaceuticals Ltd) | |
| Siliver (Brazil) | |
| Silliver (Taiwan) | |
| Silliver 70 mg x 120's (Abbott) | |
| Silliver 70 mg x 500's (Abbott) | |
| Silmar (Colombia) | |
| Siluma (Taiwan) | |
| Siluma 70 mg | |
| Silvaysan (Germany) | |
| Capsule; Oral; Milk Thistle (Sanum-kehlbeck) | |
| Sily-Sabona (Germany) | |
| Capsule; Oral; Milk Thistle (Sabona) | |
| Silybon (India) | |
| Silybon 70mg TAB / 10 (Micro Labs Ltd) | $ 0.70 |
| Silybon 140mg TAB / 10 (Micro Labs Ltd) | $ 0.94 |
| Silybon 35mg/5mL SUSP / 100ml (Micro Labs Ltd) | $ 1.04 |
See 514 substitutes for Silimarin | |
References
- PubChem. "silibinin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Silibinin A". http://www.drugbank.ca/drugs/DB09298 (accessed September 17, 2018).
- DTP/NCI. "NSC651520: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Silimarin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Silimarin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
